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PDBsum entry 2xnb

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protein ligands links
Transferase PDB id
2xnb
Jmol
Contents
Protein chain
296 a.a. *
Ligands
Y8L
Waters ×260
* Residue conservation analysis
PDB id:
2xnb
Name: Transferase
Title: Discovery and characterisation of 2-anilino-4-(thiazol-5-yl) pyrimidine transcriptional cdk inhibitors as anticancer agents
Structure: Cell division protein kinase 2. Chain: a. Synonym: p33 protein kinase. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Resolution:
1.85Å     R-factor:   0.215     R-free:   0.293
Authors: S.Wang,G.Griffiths,C.A.Midgley,A.L.Barnett,M.Cooper,J.Grabar L.Ingram,W.Jackson,G.Kontopidis,S.J.Mcclue,C.Mcinnes,J.Mcla C.Meades,M.Mezna,I.Stuart,M.P.Thomas,D.I.Zheleva,D.P.Lane, R.C.Jackson,D.M.Glover,D.G.Blake,P.M.Fischer
Key ref: S.Wang et al. (2010). Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents. Chem Biol, 17, 1111-1121. PubMed id: 21035734
Date:
01-Aug-10     Release date:   10-Nov-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
296 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   15 terms 
  Biological process     regulation of gene silencing   27 terms 
  Biochemical function     nucleotide binding     12 terms  

 

 
    reference    
 
 
Chem Biol 17:1111-1121 (2010)
PubMed id: 21035734  
 
 
Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.
S.Wang, G.Griffiths, C.A.Midgley, A.L.Barnett, M.Cooper, J.Grabarek, L.Ingram, W.Jackson, G.Kontopidis, S.J.McClue, C.McInnes, J.McLachlan, C.Meades, M.Mezna, I.Stuart, M.P.Thomas, D.I.Zheleva, D.P.Lane, R.C.Jackson, D.M.Glover, D.G.Blake, P.M.Fischer.
 
  ABSTRACT  
 
No abstract given.