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PDBsum entry 2xk5
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protein metals Protein-protein interface(s) links
Protein binding PDB id
2xk5

 

 

 

 

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Contents
Protein chains
73 a.a. *
75 a.a. *
Metals
_ZN ×7
* Residue conservation analysis
PDB id:
2xk5
Name: Protein binding
Title: Crystal structure of k6-linked diubiquitin
Structure: Ubiquitin. Chain: a. Engineered: yes. Ubiquitin. Chain: b. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
3.00Å     R-factor:   0.218     R-free:   0.249
Authors: S.Virdee,J.W.Chin,D.Komander
Key ref: S.Virdee et al. (2010). Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase. Nat Chem Biol, 6, 750-757. PubMed id: 20802491
Date:
07-Jul-10     Release date:   25-Aug-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
P62979  (RS27A_HUMAN) -  Ubiquitin-ribosomal protein eS31 fusion protein from Homo sapiens
Seq:
Struc: 		156 a.a.
73 a.a.
Protein chain
P62979  (RS27A_HUMAN) -  Ubiquitin-ribosomal protein eS31 fusion protein from Homo sapiens
Seq:
Struc: 		156 a.a.
75 a.a.*
Key:    Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 

 
Nat Chem Biol 6:750-757 (2010)
PubMed id: 20802491  
 
 
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase.
S.Virdee, Y.Ye, D.P.Nguyen, D.Komander, J.W.Chin.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22157957 J.D.Licchesi, J.Mieszczanek, T.E.Mevissen, T.J.Rutherford, M.Akutsu, S.Virdee, F.El Oualid, J.W.Chin, H.Ovaa, M.Bienz, and D.Komander (2012).
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.
  Nat Struct Mol Biol, 19, 62-71.
PDB code: 3zrh
21212884 C.A.Castañeda, J.Liu, T.R.Kashyap, R.K.Singh, D.Fushman, and T.A.Cropp (2011).
Controlled enzymatic synthesis of natural-linkage, defined-length polyubiquitin chains using lysines with removable protecting groups.
  Chem Commun (Camb), 47, 2026-2028.  
21266548 M.Akutsu, Y.Ye, S.Virdee, J.W.Chin, and D.Komander (2011).
Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
  Proc Natl Acad Sci U S A, 108, 2228-2233.
PDB codes: 3phu 3phw 3phx
  21181847 T.Fekner, X.Li, and M.K.Chan (2011).
Nonenzymatic ubiquitylation.
  Chembiochem, 12, 21-33.  
21088799 W.R.Liu, Y.S.Wang, and W.Wan (2011).
Synthesis of proteins with defined posttranslational modifications using the genetic noncanonical amino acid incorporation approach.
  Mol Biosyst, 7, 38-47.  
21035729 D.P.Nguyen, M.M.Garcia Alai, S.Virdee, and J.W.Chin (2010).
Genetically directing ɛ-N, N-dimethyl-L-lysine in recombinant histones.
  Chem Biol, 17, 1072-1076.  
21111228 F.Ikeda, N.Crosetto, and I.Dikic (2010).
What determines the specificity and outcomes of ubiquitin signaling?
  Cell, 143, 677-681.  
21113135 J.N.Dynek, T.Goncharov, E.C.Dueber, A.V.Fedorova, A.Izrael-Tomasevic, L.Phu, E.Helgason, W.J.Fairbrother, K.Deshayes, D.S.Kirkpatrick, and D.Vucic (2010).
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.
  EMBO J, 29, 4198-4209.  
  21053237 L.J.Martin, and R.T.Raines (2010).
Carpe diubiquitin.
  Angew Chem Int Ed Engl, 49, 9042-9044.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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