PDBsum entry 2x4a

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Protein transport PDB id
Protein chain
327 a.a. *
PO4 ×2
Waters ×78
* Residue conservation analysis
PDB id:
Name: Protein transport
Title: Crystal structure of thE C-terminal domain of inva
Structure: Invasion protein inva. Chain: a. Fragment: residues 357-685. Engineered: yes
Source: Salmonella enterica subsp. Enterica se typhimurium. Organism_taxid: 99287. Strain: lt2. Atcc: 700720. Expressed in: escherichia coli. Expression_system_taxid: 469008.
2.54Å     R-factor:   0.209     R-free:   0.264
Authors: L.J.Worrall,M.Vuckovic,N.C.J.Strynadka
Key ref: L.J.Worrall et al. (2010). Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA. Protein Sci, 19, 1091-1096. PubMed id: 20306492
28-Jan-10     Release date:   05-May-10    
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Protein chain
Pfam   ArchSchema ?
P0A1I3  (INVA_SALTY) -  Invasion protein InvA
685 a.a.
327 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   1 term 
  Biological process     protein secretion   1 term 


Protein Sci 19:1091-1096 (2010)
PubMed id: 20306492  
Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA.
L.J.Worrall, M.Vuckovic, N.C.Strynadka.
InvA is a prominent inner-membrane component of the Salmonella type III secretion system (T3SS) apparatus, which is responsible for regulating virulence protein export in pathogenic bacteria. InvA is made up of an N-terminal integral membrane domain and a C-terminal cytoplasmic domain that is proposed to form part of a docking platform for the soluble export apparatus proteins notably the T3SS ATPase InvC. Here, we report the novel crystal structure of the C-terminal domain of Salmonella InvA which shows a compact structure composed of four subdomains. The overall structure is unique although the first and second subdomains exhibit structural similarity to the peripheral stalk of the A/V-type ATPase and a ring building motif found in other T3SS proteins respectively.

Literature references that cite this PDB file's key reference

  PubMed id Reference
21112241 L.J.Worrall, E.Lameignere, and N.C.Strynadka (2011).
Structural overview of the bacterial injectisome.
  Curr Opin Microbiol, 14, 3-8.  
  20941389 C.S.Barker, I.V.Meshcheryakova, A.S.Kostyukova, and F.A.Samatey (2010).
FliO regulation of FliP in the formation of the Salmonella enterica flagellum.
  PLoS Genet, 6, 0.  
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