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PDBsum entry 2www

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protein ligands Protein-protein interface(s) links
Transport protein PDB id
2www
Jmol
Contents
Protein chains
298 a.a. *
299 a.a. *
314 a.a. *
Ligands
2PE ×3
GDP ×4
Waters ×87
* Residue conservation analysis
PDB id:
2www
Name: Transport protein
Title: Crystal structure of methylmalonic acidemia type a protein
Structure: Methylmalonic aciduria type a protein, mitochondrial. Chain: a, b, c, d. Fragment: gtpase, residues 72-418. Synonym: methylmalonic acidemia type a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2
Resolution:
2.64Å     R-factor:   0.184     R-free:   0.221
Authors: J.R.C.Muniz,C.Gileadi,D.S.Froese,W.W.Yue,A.C.W.Pike, F.Von Delft,G.Kochan,R.Sethi,A.Chaikuad,E.Pilka,S.Picaud, C.Phillips,K.Guo,E.Krysztofinska,J.Bray,N.Burgess-Brown, C.H.Arrowsmith,J.Weigelt,A.Edwards,C.Bountra,R.A.Gravel, K.L.Kavanagh,U.Oppermann
Key ref: D.S.Froese et al. (2010). Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation. J Biol Chem, 285, 38204-38213. PubMed id: 20876572 DOI: 10.1074/jbc.M110.177717
Date:
30-Oct-09     Release date:   17-Nov-09    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q8IVH4  (MMAA_HUMAN) -  Methylmalonic aciduria type A protein, mitochondrial
Seq:
Struc:
418 a.a.
298 a.a.
Protein chains
Pfam   ArchSchema ?
Q8IVH4  (MMAA_HUMAN) -  Methylmalonic aciduria type A protein, mitochondrial
Seq:
Struc:
418 a.a.
299 a.a.
Protein chain
Pfam   ArchSchema ?
Q8IVH4  (MMAA_HUMAN) -  Methylmalonic aciduria type A protein, mitochondrial
Seq:
Struc:
418 a.a.
314 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 

 
DOI no: 10.1074/jbc.M110.177717 J Biol Chem 285:38204-38213 (2010)
PubMed id: 20876572  
 
 
Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.
D.S.Froese, G.Kochan, J.R.Muniz, X.Wu, C.Gileadi, E.Ugochukwu, E.Krysztofinska, R.A.Gravel, U.Oppermann, W.W.Yue.
 
  ABSTRACT  
 
No abstract given.