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PDBsum entry 2wtf
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Transferase/DNA
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PDB id
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2wtf
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase/DNA
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Title:
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DNA polymerase eta in complex with the cis-diammineplatinum (ii) 1,3- gtg intrastrand cross-link
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Structure:
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DNA polymerase eta. Chain: a, b. Fragment: residues 1-513. Synonym: DNA polymerase eta rad30, radiation-sensitive protein 30. Engineered: yes. 5'-d( Tp Cp Tp Tp Cp Tp Gp Tp Gp Cp Tp Cp Ap Cp Cp Ap Cp)- 3'. Chain: o, s. Engineered: yes.
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Source:
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Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic: yes
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Resolution:
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2.50Å
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R-factor:
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0.229
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R-free:
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0.269
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Authors:
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T.Reissner,S.Schneider,O.Ziv,S.Schorr,Z.Livneh,T.Carell
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Key ref:
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T.Reissner
et al.
(2010).
Crystal structure of a cisplatin-(1,3-GTG) cross-link within DNA polymerase eta.
Angew Chem Int Ed Engl,
49,
3077-3080.
PubMed id:
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Date:
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16-Sep-09
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Release date:
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31-Mar-10
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PROCHECK
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Headers
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References
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Q04049
(POLH_YEAST) -
DNA polymerase eta from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
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Seq:
Struc:
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632 a.a.
509 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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T-C-T-G-T-G-C-T-C-A-C-C-A-C
14 bases
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G-T-G-G-T-G-A-G-C
9 bases
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T-G-T-G-C-T-C-A-C-C-A-C
12 bases
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G-T-G-G-T-G-A-G-C
9 bases
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Enzyme class:
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E.C.2.7.7.7
- DNA-directed Dna polymerase.
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Reaction:
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DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
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DNA(n)
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+
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2'-deoxyribonucleoside 5'-triphosphate
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=
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DNA(n+1)
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+
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diphosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Angew Chem Int Ed Engl
49:3077-3080
(2010)
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PubMed id:
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Crystal structure of a cisplatin-(1,3-GTG) cross-link within DNA polymerase eta.
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T.Reissner,
S.Schneider,
S.Schorr,
T.Carell.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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S.Schneider,
T.Reissner,
O.Ziv,
Z.Livneh,
and
T.Carell
(2010).
Translesion synthesis of 1,3-GTG cisplatin DNA lesions.
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Chembiochem,
11,
1521-1524.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
