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PDBsum entry 2wma

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protein ligands Protein-protein interface(s) links
Cell cycle PDB id
2wma
Jmol
Contents
Protein chains
297 a.a. *
258 a.a. *
266 a.a. *
Ligands
ARG-LYS-LEU-PHE-
ASN
Waters ×95
* Residue conservation analysis
PDB id:
2wma
Name: Cell cycle
Title: Structural and thermodynamic consequences of cyclization of ligands for the recruitment site of cyclin a
Structure: Cell division protein kinase 2. Chain: a, c. Synonym: cdk2, p33 protein kinase. Engineered: yes. Cyclin-a2. Chain: b, d. Fragment: residues 174-432. Synonym: cyclin-a. Engineered: yes.
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606
Resolution:
2.80Å     R-factor:   0.214     R-free:   0.285
Authors: G.F.Robertson,J.A.Endicott,M.E.M.Noble,J.M.Mcdonnell
Key ref: G.F.Robertson et al. Structural and thermodynamic consequences of cyclizat peptide ligands for the recruitment site of cyclin a. To be published, .
Date:
30-Jun-09     Release date:   01-Sep-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
297 a.a.*
Protein chains
Pfam   ArchSchema ?
P20248  (CCNA2_HUMAN) -  Cyclin-A2
Seq:
Struc:
432 a.a.
258 a.a.
Protein chain
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
266 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, C: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   14 terms 
  Biological process     regulation of gene silencing   29 terms 
  Biochemical function     nucleotide binding     13 terms