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Immune system PDB id
2win
Jmol
Contents
Protein chains
638 a.a. *
901 a.a. *
507 a.a. *
84 a.a. *
Ligands
NDG-NAG-BMA-BMA ×4
BMA ×2
NDG-NAG-BMA-BMA-
BMA ×2
NDG-NAG-BMA-BMA-
BMA-BMA
MAN ×2
NDG-NAG-MAN-MAN ×2
NDG-NAG-MAN ×2
NDG-NAG
NDG ×2
NDG-NAG-BMA
Metals
_MG ×4
Waters ×8
* Residue conservation analysis
PDB id:
2win
Name: Immune system
Title: C3 convertase (c3bbb) stabilized by scin
Structure: Complement c3 beta chain. Chain: a, c, e, g. Fragment: complement c3b beta chain, residues 23-667. Complement c3b alpha' chain. Chain: b, d, f, h. Fragment: complement c3b alpha' chain, residues 749-1663. Complement factor b. Chain: i, j, k, l. Fragment: complement factor b bb fragment, residues
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_variant: gnti-. Expression_system_cell_line: hek293es. Staphylococcus aureus. Organism_taxid: 1280.
Resolution:
3.90Å     R-factor:   0.253     R-free:   0.267
Authors: J.Wu,B.J.Janssen,P.Gros
Date:
13-May-09     Release date:   09-Jun-09    
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01024  (CO3_HUMAN) -  Complement C3
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1663 a.a.
638 a.a.
Protein chains
Pfam   ArchSchema ?
P01024  (CO3_HUMAN) -  Complement C3
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1663 a.a.
901 a.a.
Protein chains
Pfam   ArchSchema ?
P00751  (CFAB_HUMAN) -  Complement factor B
Seq:
Struc: 		 
Seq:
Struc: 		764 a.a.
507 a.a.
Protein chains
Pfam   ArchSchema ?
Q6GFB4  (SCIN_STAAR) -  Staphylococcal complement inhibitor
Seq:
Struc: 		116 a.a.
84 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: Chains I, J, K, L: E.C.3.4.21.47  - Alternative-complement-pathway C3/C5 convertase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Cleaves C3 in the alpha-chain to yield C3a and C3b. Cleaves C5 in the alpha-chain to yield C5a and C5b. Both cleavages take place at the C-terminal of an arginine residue.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   2 terms 
  Biological process     pathogenesis   2 terms 
  Biochemical function     catalytic activity     4 terms