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PDBsum entry 2wi0

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protein ligands metals links
Hydrolase PDB id
2wi0
Jmol
Contents
Protein chain
316 a.a. *
Ligands
LEU-TRP
PEG
Metals
_ZN
_CA ×4
Waters ×327
* Residue conservation analysis
PDB id:
2wi0
Name: Hydrolase
Title: Dipeptide inhibitors of thermolysin
Structure: Thermolysin. Chain: a. Synonym: thermostable neutral proteinase. Engineered: yes. Other_details: the di-peptide lw is bound to the protein
Source: Bacillus thermoproteolyticus. Organism_taxid: 1427. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.95Å     R-factor:   0.170     R-free:   0.219
Authors: B.A.Lund,I.Leiros,H.-K.S.Leiros
Key ref: B.A.Lund et al. Dipeptide inhibitors of thermolysin. To be published, .
Date:
07-May-09     Release date:   12-May-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00800  (THER_BACTH) -  Thermolysin
Seq:
Struc:
 
Seq:
Struc:
548 a.a.
316 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.4.24.27  - Thermolysin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
      Cofactor: Ca(2+); Zn(2+)
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     proteolysis   1 term 
  Biochemical function     metalloendopeptidase activity     1 term