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PDBsum entry 2whi

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protein ligands metals Protein-protein interface(s) links
Ligase PDB id
2whi
Jmol
Contents
Protein chains
(+ 0 more) 476 a.a. *
Ligands
1AZ ×6
P3S ×6
PO4 ×6
1PE ×6
Metals
_MG ×18
_CL ×6
Waters ×1649
* Residue conservation analysis
PDB id:
2whi
Name: Ligase
Title: Crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with a purine analogue inhibitor and l-methionine-s-sulfoximine phosphate.
Structure: Glutamine synthetase 1. Chain: a, b, c, d, e, f. Fragment: residues 2-478. Synonym: glutamate--ammonia ligase 1. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.20Å     R-factor:   0.211     R-free:   0.231
Authors: M.T.Nilsson,W.W.Krajewski,T.A.Jones,S.L.Mowbray
Date:
05-May-09     Release date:   01-Sep-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam  
P9WN39  (GLNA1_MYCTU) -  Glutamine synthetase 1
Seq:
Struc:
478 a.a.
476 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.6.3.1.2  - Glutamate--ammonia ligase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine
ATP
+ L-glutamate
+ NH(3)
= ADP
+
phosphate
Bound ligand (Het Group name = PO4)
corresponds exactly
+ L-glutamine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   5 terms 
  Biological process     growth   7 terms 
  Biochemical function     catalytic activity     5 terms