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PDBsum entry 2w2c
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Structure of the tetradecameric oligomerisation domain of calcium- calmodulin dependent protein kinase ii delta
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Structure:
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Calcium/calmodulin-dependent protein kinase type ii delta chain. Chain: a, b, c, d, e, f, g, h, i, j, k, l, m, n. Fragment: oligomerisation domain, residues 334-475. Synonym: calcium camoldulin dependent kinase 2d. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.
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Resolution:
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2.70Å
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R-factor:
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0.212
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R-free:
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0.245
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Authors:
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A.C.W.Pike,P.Rellos,R.Sethi,E.Salah,N.Burgess-Brown,L.Shrestha, A.Roos,J.W.Murray,F.Von Delft,A.Edwards,C.H.Arrowsmith,J.Weigelt, C.Bountra,S.Knapp
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Key ref:
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P.Rellos
et al.
(2010).
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
Plos Biol,
8,
e1000426.
PubMed id:
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Date:
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28-Oct-08
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Release date:
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23-Dec-08
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PROCHECK
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Headers
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References
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Q13557
(KCC2D_HUMAN) -
Calcium/calmodulin-dependent protein kinase type II subunit delta from Homo sapiens
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Seq:
Struc:
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499 a.a.
128 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.11.17
- calcium/calmodulin-dependent protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Cofactor:
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Ca(2+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Plos Biol
8:e1000426
(2010)
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PubMed id:
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Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
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P.Rellos,
A.C.Pike,
F.H.Niesen,
E.Salah,
W.H.Lee,
F.von Delft,
S.Knapp.
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ABSTRACT
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Links
