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PDBsum entry 2vq6

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protein ligands links
Hydrolase PDB id
2vq6
Jmol
Contents
Protein chain
529 a.a. *
Ligands
FP1
SO4
NAG ×2
Waters ×93
* Residue conservation analysis
PDB id:
2vq6
Name: Hydrolase
Title: Torpedo californica acetylcholinesterase complexed with 2- pam
Structure: Acetylcholinesterase. Chain: a. Fragment: residues 22-464. Synonym: ache. Other_details: 2-formyl-1-methyl-pyridinium chloride (pralydoxime, 2-pam) in active site gorge
Source: Torpedo californica. Pacific electric ray. Organism_taxid: 7787
Resolution:
2.71Å     R-factor:   0.174     R-free:   0.234
Authors: M.Harel,I.Silman,J.L.Sussman
Key ref: M.Harel et al. The structure of torpedo californica acetylcholinesterase complexed with 2-Pam. To be published, .
Date:
11-Mar-08     Release date:   13-May-08    
Supersedes: 2vb4
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P04058  (ACES_TORCA) -  Acetylcholinesterase
Seq:
Struc:
 
Seq:
Struc:
586 a.a.
529 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.1.1.7  - Acetylcholinesterase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Acetylcholine + H2O = choline + acetate
Acetylcholine
Bound ligand (Het Group name = NAG)
matches with 41.00% similarity
+ H(2)O
=
choline
Bound ligand (Het Group name = FP1)
matches with 41.00% similarity
+ acetate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     synapse   5 terms 
  Biological process     neurotransmitter catabolic process   2 terms 
  Biochemical function     hydrolase activity     3 terms