PDBsum entry: 2vcp

Structural protein

PDB id: 2vcp

Contents

Protein chains

371 a.a.

20 a.a. *

Ligands

ATP ×2

Metals

_CA ×2

* Residue conservation analysis

PDB id:

2vcp

Name:

Structural protein

Title:

Crystal structure of n-wasp vc domain in complex with skeletal actin

Structure:

Actin, alpha skeletal muscle. Chain: a, b. Fragment: residues 3-377. Synonym: alpha-actin-1. Neural wiskott-aldrich syndrome protein. Chain: d, e. Fragment: wh2 1,2 and c domain, residues 392-484. Synonym: n-wasp. Engineered: yes

Source:

Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: skeletal muscle. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

3.20Å R-factor: 0.275 R-free: 0.331

Authors:

J.F.Gaucher,D.Didry,M.F.Carlier

Key ref:

J.F.Gaucher et al. Crystal structure of n-Wasp wh2 domain in complex with skeletal actin. To be published,

Date:

26-Sep-07 Release date: 04-Nov-08

Protein chains

P68135  (ACTS_RABIT) -  Actin, alpha skeletal muscle

Seq: 377 a.a.

Struc: 371 a.a.*

Protein chains

O00401  (WASL_HUMAN) -  Neural Wiskott-Aldrich syndrome protein

Seq: 505 a.a.

Struc: 20 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 

• Cellular component: cytoplasm (9 terms)
• Biological process: protein complex assembly (12 terms)
• Biochemical function: nucleotide binding (6 terms)