PDBsum entry: 2vac

Transferase

PDB id: 2vac

Contents

Protein chain

134 a.a. *

Ligands

EDO

Metals

_ZN ×3

Waters ×161

* Residue conservation analysis

PDB id:

2vac

Name:

Transferase

Title:

Structure of n-terminal actin depolymerizing factor homology (adf-h) domain of human twinfilin-2

Structure:

Twinfilin-2. Chain: a. Fragment: actin depolymerizing factor homology (adf-h) doma residues 6-137. Synonym: twinfilin-1-like protein, a6-related protein, ha6r protein tyrosine kinase 9-like. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.

Resolution:

1.70Å R-factor: 0.172 R-free: 0.214

Authors:

J.M.Elkins,A.C.W.Pike,O.King,E.Salah,P.Savitsky,F.Von Delft, J.Weigelt,A.Edwards,C.H.Arrowsmith,M.Sundstrom,S.Knapp

Key ref:

J.M.Elkins et al. Crystal structure of n-Terminal actin depolymerizing factor homology (adf-H) domain of human twinfilin-2. To be published,

Date:

30-Aug-07 Release date: 16-Oct-07

Protein chain

Q6IBS0  (TWF2_HUMAN) -  Twinfilin-2

Seq: 349 a.a.

Struc: 134 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 

• Cellular component: intracellular (1 term)
• Biochemical function: actin binding (1 term)