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PDBsum entry 2v40

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protein ligands links
Ligase PDB id
2v40
Jmol
Contents
Protein chain
419 a.a. *
Ligands
GDP
Waters ×538
* Residue conservation analysis
PDB id:
2v40
Name: Ligase
Title: Human adenylosuccinate synthetase isozyme 2 in complex with gdp
Structure: Adenylosuccinate synthetase isozyme 2. Chain: a. Fragment: residues 21-456. Synonym: adenylosuccinate synthetase acidic isozyme, imp-aspartate ligase 2, adss 2, ampsase 2. Engineered: yes. Other_details: the protein chain contains a hexahistidine tail in the n-terminus
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
1.90Å     R-factor:   0.166     R-free:   0.198
Authors: M.Welin,M.Moche,C.Arrowsmith,H.Berglund,R.Busam,R.Collins, L.G.Dahlgren,A.Edwards,S.Flodin,A.Flores,S.Graslund, M.Hammarstrom,B.M.Hallberg,L.Holmberg-Schiavone, I.Johansson,A.Kallas,T.Karlberg,T.Kotenyova,L.Lehtio, T.Nyman,D.Ogg,C.Persson,J.Sagemark,P.Stenmark,M.Sundstrom, A.G.Thorsell,L.Tresaugues,S.Van-Den-Berg,J.Weigelt, P.Nordlund,Structural Genomics Consortium (Sgc)
Key ref: M.Welin et al. Human adenylosuccinate synthetase isozyme 2 in complex with gdp. To be published, .
Date:
27-Jun-07     Release date:   10-Jul-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P30520  (PURA2_HUMAN) -  Adenylosuccinate synthetase isozyme 2
Seq:
Struc:
456 a.a.
419 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.6.3.4.4  - Adenylosuccinate synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
AMP and GMP Biosynthesis
      Reaction: GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)- AMP
GTP
+ IMP
+ L-aspartate
=
GDP
Bound ligand (Het Group name = GDP)
corresponds exactly
+ phosphate
+ N(6)-(1,2-dicarboxyethyl)- AMP
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   2 terms 
  Biological process     immune system process   14 terms 
  Biochemical function     nucleotide binding     8 terms