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PDBsum entry 2uzq

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protein ligands Protein-protein interface(s) links
Hydrolase PDB id
2uzq
Jmol
Contents
Protein chain
(+ 0 more) 172 a.a. *
Ligands
PO4 ×6
Waters ×196
* Residue conservation analysis
PDB id:
2uzq
Name: Hydrolase
Title: Protein phosphatase, new crystal form
Structure: M-phase inducer phosphatase 2. Chain: a, b, c, d, e, f. Fragment: catalytic domain, residues 377-566. Synonym: dual specificity phosphatase cdc25b, cdc25b. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.38Å     R-factor:   0.226     R-free:   0.249
Authors: R.C.Hillig,U.Eberspaecher
Key ref: R.C.Hillig and u.eberspaecher New crystal form of protein phosphatase cdc25b triggered by guanidinium chloride as an additive. To be published, .
Date:
01-May-07     Release date:   24-Jun-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P30305  (MPIP2_HUMAN) -  M-phase inducer phosphatase 2
Seq:
Struc:
 
Seq:
Struc:
580 a.a.
172 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+
phosphate
Bound ligand (Het Group name = PO4)
corresponds exactly
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     intracellular   1 term 
  Biological process     M phase of mitotic cell cycle   2 terms 
  Biochemical function     protein tyrosine phosphatase activity     1 term