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PDBsum entry 2uzp

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protein ligands metals Protein-protein interface(s) links
Transferase PDB id
2uzp
Jmol
Contents
Protein chain
142 a.a. *
Ligands
PLP ×3
SO4 ×20
EDO ×8
Metals
_CO ×3
_CA ×9
Waters ×392
* Residue conservation analysis
PDB id:
2uzp
Name: Transferase
Title: Crystal structure of the c2 domain of human protein kinase c
Structure: Protein kinasE C gamma type. Chain: a, b, c. Fragment: c2 domain, residues 154-295. Synonym: protein kinasE C gamma, pkc-gamma. Engineered: yes. Other_details: schiffs base link between ser -1 and pyridox phosphate plp300
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.00Å     R-factor:   0.172     R-free:   0.205
Authors: A.C.W.Pike,A.Amos,C.Johansson,F.Sobott,P.Savitsky,G.Berridge O.Fedorov,C.Umeano,F.Gorrec,G.Bunkoczi,J.Debreczeni,F.Von D C.H.Arrowsmith,A.Edwards,J.Weigelt,M.Sundstrom,S.Knapp
Key ref: A.C.W.Pike et al. Crystal structure of c2 domain of protein kinase c gamma. To be published, .
Date:
30-Apr-07     Release date:   29-May-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P05129  (KPCG_HUMAN) -  Protein kinase C gamma type
Seq:
Struc:
 
Seq:
Struc:
697 a.a.
142 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.13  - Protein kinase C.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
=
ADP
Bound ligand (Het Group name = PLP)
matches with 44.83% similarity
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site