spacer
spacer

PDBsum entry 2riw

Go to PDB code: 
protein ligands Protein-protein interface(s) links
Signaling protein PDB id
2riw
Jmol
Contents
Protein chains
337 a.a. *
34 a.a. *
Ligands
T44
Waters ×295
* Residue conservation analysis
PDB id:
2riw
Name: Signaling protein
Title: The reactive loop cleaved human thyroxine binding globulin c with thyroxine
Structure: Thyroxine-binding globulin. Chain: a. Fragment: n-terminal domain, unp residues 39-375. Synonym: tbg, t4-binding globulin, serpin a7. Engineered: yes. Thyroxine-binding globulin. Chain: b. Fragment: reactive loop cleaved tbg, c-teemingly domain, un 376-415.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: serpina7, tbg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.04Å     R-factor:   0.198     R-free:   0.244
Authors: A.Zhou,Z.Wei,P.L.D.Stanley,R.J.Read,P.E.Stein,R.W.Carrell
Key ref: X.Qi et al. (2011). Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins. J Biol Chem, 286, 16163-16173. PubMed id: 21325280
Date:
12-Oct-07     Release date:   14-Oct-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P05543  (THBG_HUMAN) -  Thyroxine-binding globulin
Seq:
Struc:
415 a.a.
337 a.a.*
Protein chain
Pfam   ArchSchema ?
P05543  (THBG_HUMAN) -  Thyroxine-binding globulin
Seq:
Struc:
415 a.a.
34 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 9 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   1 term 

 

 
J Biol Chem 286:16163-16173 (2011)
PubMed id: 21325280  
 
 
Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.
X.Qi, F.Loiseau, W.L.Chan, Y.Yan, Z.Wei, L.G.Milroy, R.M.Myers, S.V.Ley, R.J.Read, R.W.Carrell, A.Zhou.
 
  ABSTRACT  
 
No abstract given.