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PDBsum entry 2rhg

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protein ligands metals Protein-protein interface(s) links
Lyase PDB id
2rhg
Jmol
Contents
Protein chains
250 a.a. *
364 a.a. *
Ligands
IGP
PLP
Metals
_NA
Waters ×273
* Residue conservation analysis
PDB id:
2rhg
Name: Lyase
Title: Tryptophan synthase complexed with igp, ph 7.0, internal ald
Structure: Tryptophan synthase alpha chain. Chain: a. Engineered: yes. Tryptophan synthase beta chain. Chain: b. Engineered: yes
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: trpa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trpb.
Resolution:
2.00Å     R-factor:   0.212     R-free:   0.239
Authors: V.Kulik,T.Barends,I.Schlichting
Key ref: V.Kulik et al. Tryptophan synthase complexed with igp, Ph 7.0, Internal aldimine. To be published, .
Date:
09-Oct-07     Release date:   20-Nov-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00929  (TRPA_SALTY) -  Tryptophan synthase alpha chain
Seq:
Struc:
268 a.a.
250 a.a.
Protein chain
Pfam   ArchSchema ?
P0A2K1  (TRPB_SALTY) -  Tryptophan synthase beta chain
Seq:
Struc:
397 a.a.
364 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.4.2.1.20  - Tryptophan synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Tryptophan Biosynthesis
      Reaction: L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
L-serine
+
1-C-(indol-3-yl)glycerol 3-phosphate
Bound ligand (Het Group name = IGP)
corresponds exactly
= L-tryptophan
+ D-glyceraldehyde 3-phosphate
+ H(2)O
      Cofactor: Pyridoxal 5'-phosphate
Pyridoxal 5'-phosphate
Bound ligand (Het Group name = PLP) matches with 93.75% similarity
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     metabolic process   5 terms 
  Biochemical function     catalytic activity     4 terms