PDBsum entry: 2rf6

Hydrolase

PDB id: 2rf6

Contents

Protein chain

170 a.a. *

Ligands

SO4

Waters ×172

* Residue conservation analysis

PDB id:

2rf6

Name:

Hydrolase

Title:

Crystal structure of the vaccinia virus dual-specificity phosphatase vh1

Structure:

Dual specificity protein phosphatase. Chain: a. Synonym: late protein h1. Engineered: yes. Mutation: yes

Source:

Vaccinia virus. Organism_taxid: 10245. Strain: western reserve/wr. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.95Å R-factor: 0.188 R-free: 0.208

Authors:

A.C.Koksal,G.Cingolani

Key ref:

A.C.Koksal et al. Crystal structure of the vaccinia virus dual-Specificity phosphatase vh1. To be published,

Date:

28-Sep-07 Release date: 30-Sep-08

Protein chain

P07239  (DUSP_VACCW) -  Dual specificity protein phosphatase H1

Seq: 171 a.a.

Struc: 170 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - Protein-tyrosine-phosphatase.
• Reaction: Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: virion (2 terms)
• Biological process: peptidyl-tyrosine dephosphorylation (5 terms)
• Biochemical function: hydrolase activity (5 terms)