PDBsum entry: 2r42

Transferase

PDB id

2r42

Contents

			Protein chain

					383 a.a. *

			Ligands

					FPS

			Metals

					_MG

			Waters ×73

* Residue conservation analysis

PDB id:

2r42

Links
- PDBe
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- PDBWiki
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Name:

Transferase

Title:

The biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism

Structure:

Mevalonate kinase. Chain: a. Synonym: mk. Engineered: yes

Source:

Rattus norvegicus. Rat. Gene: mvk. Expressed in: escherichia coli.

Resolution:

2.40Å

R-factor:

0.235

R-free:

0.272

Authors:

Z.Fu,N.E.Voynova,H.M.Miziorko,J.P.Kim

Date:

30-Aug-07

Release date:

24-Jun-08

PROCHECK

	Headers

	References

Protein chain

P17256 (KIME_RAT) - Mevalonate kinase

Seq: Struc:					395 a.a. 383 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.2.7.1.36 - Mevalonate kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Terpenoid biosynthesis

Reaction:

ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate

ATP	+	(R)-mevalonate	=	ADP	+	(R)-5-phosphomevalonate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site



		Gene Ontology (GO) functional annotation

Cellular component	soluble fraction	4 terms
Biological process	metabolic process	12 terms
Biochemical function	nucleotide binding	7 terms