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protein ligands metals Protein-protein interface(s) links
Signaling protein/transferase PDB id
2qme
Jmol
Contents
Protein chains
178 a.a. *
24 a.a. *
Ligands
GCP
GOL ×2
Metals
_MG
Waters ×238
* Residue conservation analysis
PDB id:
2qme
Name: Signaling protein/transferase
Title: Crystal structure of human rac3 in complex with crib domain p21-activated kinase 1 (pak1)
Structure: Ras-related c3 botulinum toxin substrate 3. Chain: a. Synonym: p21-rac3. Engineered: yes. Crib domain of the serine/threonine-protein kinas chain: i. Fragment: crib domain. Synonym: p21-activated kinase 1, pak-1, p65-pak, alpha-pak. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rac3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide with the sequence of thE C domain of human pak1 protein
Resolution:
1.75Å     R-factor:   0.151     R-free:   0.192
Authors: E.Ugochukwu,X.Yang,J.M.Elkins,N.Burgess-Brown,G.Bunkoczi,M.S C.H.Arrowsmith,J.Weigelt,A.Edwards,F.Von Delft,S.Knapp,D.Do Structural Genomics Consortium (Sgc)
Key ref: E.Ugochukwu et al. The crystal structure of the human rac3 in complex with the crib domain of human p21-Activated kinase 1 (pak1).. To be published,
Date:
16-Jul-07     Release date:   28-Aug-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P60763  (RAC3_HUMAN) -  Ras-related C3 botulinum toxin substrate 3
Seq:
Struc:
192 a.a.
178 a.a.*
Protein chain
Pfam   ArchSchema ?
Q13153  (PAK1_HUMAN) -  Serine/threonine-protein kinase PAK 1
Seq:
Struc:
 
Seq:
Struc:
545 a.a.
24 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: Chain I: E.C.2.7.11.1  - Non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
=
ADP
Bound ligand (Het Group name = GCP)
matches with 78.79% similarity
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     intracellular   12 terms 
  Biological process     intracellular signal transduction   9 terms 
  Biochemical function     nucleotide binding     4 terms