PDBsum entry: 2qme

Signaling protein/transferase

PDB-id: 2qme

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Description

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References

PROCHECK

Protein chains

178 a.a. *

24 a.a. *

Ligands

GCP

GOL ×2

Metal ions

_MG

Waters ×238

* Residue conservation analysis

Tools

Clefts Calculation

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PDB id:

2qme

Name:

Signaling protein/transferase

Title:

Crystal structure of human rac3 in complex with crib domain of human p21-activated kinase 1 (pak1)

Structure:

Ras-related c3 botulinum toxin substrate 3. Chain: a. Synonym: p21-rac3. Engineered: yes. Crib domain of the serine/threonine-protein kinase pak 1. Chain: i. Fragment: crib domain. Synonym: p21-activated kinase 1, pak-1, p65-pak, alpha-pak.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: rac3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide with the sequence of the crib domain of human pak1 protein

UniProt:

Chain A: P60763 (RAC3_HUMAN)

Seq:	192 a.a.
Struc:	178 a.a.*

Chain I: Q13153 (PAK1_HUMAN)

Seq:

Struc:

Seq:

Struc:

Seq:

545 a.a.

Struc:

24 a.a.

Key:	PfamA domain
Secondary structure	CATH domain

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme class:

Chain I: E.C.2.7.11.1   [IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

Reaction:

ATP + a protein = ADP + a phosphoprotein

Resolution:

1.75Å

R-factor:

0.151

R-free:

0.192

Authors:

E.Ugochukwu,X.Yang,J.M.Elkins,N.Burgess-Brown,G.Bunkoczi, M.Sundstrom,C.H.Arrowsmith,J.Weigelt,A.Edwards,F.Von Delft, S.Knapp,D.Doyle,Structural Genomics Consortium (Sgc)

Key ref:

e.ugochukwu et al. the crystal structure of the human rac3 in complex with the crib domain of human p21-activated kinase 1 (pak1).. TO BE PUBLISHED, .

Date:

16-Jul-07

Release date:

28-Aug-07

Related entries:

2g0n
crystal structure of human rac3 in complex with gdp and
chlorine

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