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PDBsum entry 2qfv

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
2qfv
Jmol
Contents
Protein chains
410 a.a. *
Ligands
NAP ×4
Waters ×950
* Residue conservation analysis
PDB id:
2qfv
Name: Oxidoreductase
Title: Crystal structure of saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with NADP(+)
Structure: Isocitrate dehydrogenase [nadp]. Chain: a, b, c, d. Synonym: idp1p, oxalosuccinate decarboxylase, idh, NADP+, - specific icdh, idp. Engineered: yes
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Strain: yph499. Gene: idp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.30Å     R-factor:   0.198     R-free:   0.258
Authors: Y.J.Peng,J.P.Ding
Date:
28-Jun-07     Release date:   01-Jul-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P21954  (IDHP_YEAST) -  Isocitrate dehydrogenase [NADP], mitochondrial
Seq:
Struc:
428 a.a.
410 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.1.1.42  - Isocitrate dehydrogenase (NADP(+)).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Citric acid cycle
      Reaction: Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH
Isocitrate
+
NADP(+)
Bound ligand (Het Group name = NAP)
corresponds exactly
= 2-oxoglutarate
+ CO(2)
+ NADPH
      Cofactor: Mn(2+) or Mg(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     mitochondrion   2 terms 
  Biological process     oxidation-reduction process   5 terms 
  Biochemical function     protein binding     7 terms