PDBsum entry 2q60

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protein Protein-protein interface(s) links
Transcription PDB id
Protein chains
198 a.a. *
Waters ×175
* Residue conservation analysis
PDB id:
Name: Transcription
Title: Crystal structure of the ligand binding domain of polyandroc misakiensis rxr in tetramer in absence of ligand
Structure: Retinoid x receptor. Chain: a, b, c, d. Fragment: ligand binding domain. Engineered: yes. Mutation: yes
Source: Polyandrocarpa misakiensis. Ascidiacea. Organism_taxid: 7723. Gene: pmrxr. Expressed in: escherichia coli. Expression_system_taxid: 562.
2.90Å     R-factor:   0.272     R-free:   0.325
Authors: F.Borel,A.De Groot,C.Juillan-Binard,E.De Rosny,V.Laudet,E.Pe Peyroula,J.-C.Fontecilla-Camps,J.-L.Ferrer
Key ref:
F.Borel et al. (2009). Crystal structure of the ligand-binding domain of the retinoid X receptor from the ascidian Polyandrocarpa misakiensis. Proteins, 74, 538-542. PubMed id: 19004016 DOI: 10.1002/prot.22294
04-Jun-07     Release date:   27-May-08    
Go to PROCHECK summary

Protein chains
Pfam   ArchSchema ?
Q9UAF1  (Q9UAF1_POLMI) -  Retinoid X receptor (Fragment)
363 a.a.
198 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     steroid hormone mediated signaling pathway   2 terms 
  Biochemical function     DNA binding     4 terms  


DOI no: 10.1002/prot.22294 Proteins 74:538-542 (2009)
PubMed id: 19004016  
Crystal structure of the ligand-binding domain of the retinoid X receptor from the ascidian Polyandrocarpa misakiensis.
F.Borel, Groot, C.Juillan-Binard, Rosny, V.Laudet, E.Pebay-Peyroula, J.C.Fontecilla-Camps, J.L.Ferrer.
No abstract given.

  Selected figure(s)  
Figure 1.
Figure 1. Structure of the Pm RXR LBD tetramer. (A) Overall ribbon representation of the tetramer consisting of a bottom to bottom dimer of dimers. The two red monomers (A1, B1) form one canonical dimer and the two blue ones, its symmetric (A2, B2). Overlap of monomer A H11/H12 onto monomer B is represented in beige. (B) Stereo view of the superposition of monomer A and B showing the two different H11/H12 conformations. (C) Close view of the ligand binding pocket of monomer A and B. Ligand molecules found in other RXR structures have been added in Pm RXR. The 9-cis retinoic acid from BgRXR (PDB code 1XIU) is depicted in black and the non-activating trans retinoic acid from hRXR (PBD code 1G5Y) in yellow.
  The above figure is reprinted by permission from John Wiley & Sons, Inc.: Proteins (2009, 74, 538-542) copyright 2009.