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Oxidoreductase
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PDB id
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2q3e
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Contents |
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* Residue conservation analysis
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PDB id:
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Oxidoreductase
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Title:
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Structure of human udp-glucose dehydrogenase complexed with udp-glucose
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Structure:
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Udp-glucose 6-dehydrogenase. Chain: a, b, c, d, e, f, g, h, i, j, k, l. Synonym: udp-glc dehydrogenase, udp-glcdh, udpgdh. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ugdh. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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2.00Å
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R-factor:
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0.173
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R-free:
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0.205
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Authors:
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K.L.Kavanagh,K.Guo,G.Bunkoczi,P.Savitsky,E.Pilka,C.Bhatia,C. G.Berridge,F.Von Delft,J.Wiegelt,C.Arrowsmith,M.Sundstrom,A U.Oppermann,Structural Genomics Consortium (Sgc)
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Key ref:
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k.l.kavanagh
et al.
(2011).
Structure and mechanism of human UDP-glucose 6-dehydrogenase.
J.Biol.Chem.,
286,
23877-23887.
PubMed id:
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Date:
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30-May-07
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Release date:
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03-Jul-07
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PROCHECK
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Headers
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References
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O60701
(UGDH_HUMAN) -
UDP-glucose 6-dehydrogenase
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Seq:
Struc:
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494 a.a.
460 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.1.1.1.22
- UDP-glucose 6-dehydrogenase.
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Pathway:
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UDP-glucose, UDP-galactose and UDP-glucuronate Biosynthesis
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Reaction:
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UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH
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UDP-glucose
Bound ligand (Het Group name = )
corresponds exactly
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+
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2
×
NAD(+)
Bound ligand (Het Group name = )
corresponds exactly
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+
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H(2)O
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=
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UDP-glucuronate
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+
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2
×
NADH
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Gene Ontology (GO) functional annotation
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Cellular component
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cytosol
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1 term
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Biological process
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oxidation-reduction process
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6 terms
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Biochemical function
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electron carrier activity
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6 terms
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J.Biol.Chem.
286:23877-23887
(2011)
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PubMed id:
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Structure and mechanism of human UDP-glucose 6-dehydrogenase.
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k.l.kavanagh,
k.guo,
g.bunkoczi,
p.savitsky,
e.pilka,
c.bhatia,
c.smee,
g.berridge,
f.von delft,
j.wiegelt,
c.arrowsmith,
m.sundstrom,
a.edwards,
u.oppermann,
structural genomics consortium (sgc).
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ABSTRACT
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Links
