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PDBsum entry 2q38

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protein ligands metals links
Lyase PDB id
2q38
Jmol
Contents
Protein chain
256 a.a. *
Ligands
LSA ×2
BEZ
GOL ×3
Metals
_ZN
_HG
Waters ×214
* Residue conservation analysis
PDB id:
2q38
Name: Lyase
Title: Carbonic anhydrase ii in complex with saccharin at 1.95 angs
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonic anhydrase ii, carbonate dehydratase ii, c carbonic anhydrasE C. Ec: 4.2.1.1
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: from human erythrocytes
Resolution:
1.95Å     R-factor:   0.184     R-free:   0.260
Authors: J.Schulze Wischeler,A.Heine,G.Klebe
Key ref: K.Köhler et al. (2007). Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste. Angew Chem Int Ed Engl, 46, 7697-7699. PubMed id: 17705204
Date:
30-May-07     Release date:   02-Oct-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
256 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   22 terms 
  Biochemical function     protein binding     5 terms  

 

 
    Added reference    
 
 
Angew Chem Int Ed Engl 46:7697-7699 (2007)
PubMed id: 17705204  
 
 
Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.
K.Köhler, A.Hillebrecht, J.Schulze Wischeler, A.Innocenti, A.Heine, C.T.Supuran, G.Klebe.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21587833 M.Akkurt, S.P.Yalçın, H.Türkmen, and O.Büyükgüngör (2010).
2-Chloro-N-(4-sulfamoylphen-yl)acetamide.
  Acta Crystallogr Sect E Struct Rep Online, 66, o1596.  
18167490 C.T.Supuran (2008).
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.
  Nat Rev Drug Discov, 7, 168-181.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.