PDBsum entry: 2q05

Hydrolase

PDB id: 2q05

Contents

Protein chains

181 a.a. *

172 a.a. *

Waters ×63

* Residue conservation analysis

PDB id:

2q05

Name:

Hydrolase

Title:

Crystal structure of tyr/ser protein phosphatase from vaccin wr

Structure:

Dual specificity protein phosphatase. Chain: a, b, c, d. Synonym: late protein h1. Engineered: yes

Source:

Vaccinia virus wr. Organism_taxid: 10254. Strain: wr (western reserve), vacv. Gene: h1l, vacwr099. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.57Å R-factor: 0.193 R-free: 0.218

Authors:

J.Osipiuk,T.Skarina,O.Kagan,A.Savchenko,A.Edwards,A.Joachimi Midwest Center For Structural Genomics (Mcsg)

Key ref:

J.Osipiuk et al. Crystal structure of tyr/ser protein phosphatase from vaccinia virus wr.. To be published,

Date:

18-May-07 Release date: 19-Jun-07

Protein chains

P07239  (DUSP_VACCW) -  Dual specificity protein phosphatase H1

Seq: 171 a.a.

Struc: 181 a.a.*

Protein chain

P07239  (DUSP_VACCW) -  Dual specificity protein phosphatase H1

Seq: 171 a.a.

Struc: 172 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.3.1.3.48 - Protein-tyrosine-phosphatase.
• Reaction: Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: virion (2 terms)
• Biological process: peptidyl-tyrosine dephosphorylation (5 terms)
• Biochemical function: hydrolase activity (5 terms)