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PDBsum entry 2pr2
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protein ligands links
Oxidoreductase PDB id
2pr2

 

 

 

 

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Contents
Protein chain
267 a.a. *
Ligands
DG1
Waters ×42
* Residue conservation analysis
PDB id:
2pr2
Name: Oxidoreductase
Title: Structure of mycobacterium tuberculosis enoyl-acp reductase with bound inh-NADP.
Structure: Enoyl-acp reductase. Chain: a. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: inha. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Resolution:
2.50Å     R-factor:   0.185     R-free:   0.217
Authors: M.W.Vetting,A.Argyrou,J.S.Blanchard
Key ref: A.Argyrou et al. (2007). New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP. J Am Chem Soc, 129, 9582-9583. PubMed id: 17636923
Date:
03-May-07     Release date:   15-Jan-08    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P9WGR1  (INHA_MYCTU) -  Enoyl-[acyl-carrier-protein] reductase [NADH] from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Seq:
Struc: 		269 a.a.
267 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.3.1.9  - enoyl-[acyl-carrier-protein] reductase (NADH).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + NADH + H+
2,3-saturated acyl-[ACP]
 +
NAD(+)
Bound ligand (Het Group name = DG1)
matches with 78.57% similarity 		= (2E)-enoyl-[ACP]
 + NADH
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
J Am Chem Soc 129:9582-9583 (2007)
PubMed id: 17636923  
 
 
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
A.Argyrou, M.W.Vetting, J.S.Blanchard.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
19526063 P.Kaur, S.Agarwal, and S.Datta (2009).
Delineating bacteriostatic and bactericidal targets in mycobacteria using IPTG inducible antisense expression.
  PLoS One, 4, e5923.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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