PDBsum entry: 2pq5

Hydrolase

PDB id: 2pq5

Contents

Protein chains

169 a.a. *

Waters ×92

* Residue conservation analysis

PDB id:

2pq5

Name:

Hydrolase

Title:

Crystal structure of dual specificity protein phosphatase 13 (dusp13)

Structure:

Dual specificity protein phosphatase 13. Chain: a, b, c, d. Synonym: testis- and skeletal-muscle-specific dsp, dual specificity phosphatase skrp4. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dusp13, tmdp. Expressed in: escherichia coli. Expression_system_taxid: 562. Resistant.

Resolution:

2.30Å R-factor: 0.195 R-free: 0.260

Authors:

E.Ugochukwu,E.Salah,P.Savitsky,A.Barr,N.Pantic,F.Niesen, N.Burgess-Brown,G.Berridge,G.Bunkoczi,J.Uppenberg, A.C.W.Pike,M.Sundstrom,C.H.Arrowsmith,J.Weigelt,A.Edwards, A.Von Delft,S.Knapp,Structural Genomics Consortium (Sgc)

Key ref:

E.Ugochukwu et al. Crystal structure of dual specificity protein phosphatase 13 (dusp13).. To be published,

Date:

01-May-07 Release date: 22-May-07

Protein chains

Q9UII6  (DUS13_HUMAN) -  Dual specificity protein phosphatase 13

Seq: 198 a.a.

Struc: 169 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 2: E.C.3.1.3.16 - Phosphoprotein phosphatase.
• Reaction: A phosphoprotein + H₂O = a protein + phosphate
• Enzyme class 3: E.C.3.1.3.48 - Protein-tyrosine-phosphatase.
• Reaction: Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biological process: spermatogenesis (4 terms)
• Biochemical function: hydrolase activity (5 terms)