PDBsum entry 2pq5

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protein Protein-protein interface(s) links
Hydrolase PDB id
Protein chain
169 a.a. *
Waters ×92
* Residue conservation analysis
PDB id:
Name: Hydrolase
Title: Crystal structure of dual specificity protein phosphatase 13
Structure: Dual specificity protein phosphatase 13. Chain: a, b, c, d. Synonym: testis- and skeletal-muscle-specific dsp, dual spe phosphatase skrp4. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dusp13, tmdp. Expressed in: escherichia coli. Expression_system_taxid: 562.
2.30Å     R-factor:   0.195     R-free:   0.260
Authors: E.Ugochukwu,E.Salah,P.Savitsky,A.Barr,N.Pantic,F.Niesen,N.Bu Brown,G.Berridge,G.Bunkoczi,J.Uppenberg,A.C.W.Pike,M.Sundst C.H.Arrowsmith,J.Weigelt,A.Edwards,F.Von Delft,S.Knapp,Stru Genomics Consortium (Sgc)
Key ref: E.Ugochukwu et al. Crystal structure of dual specificity protein phosphatase 13 (dusp13).. To be published, .
01-May-07     Release date:   22-May-07    
Go to PROCHECK summary

Protein chains
Pfam   ArchSchema ?
Q9UII6  (DUS13_HUMAN) -  Dual specificity protein phosphatase 13 isoform B
198 a.a.
169 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class 2: E.C.  - Protein-serine/threonine phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: [a protein]-serine/threonine phosphate + H2O = [a protein]- serine/threonine + phosphate
[a protein]-serine/threonine phosphate
+ H(2)O
= [a protein]- serine/threonine
+ phosphate
   Enzyme class 3: E.C.  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     peptidyl-tyrosine dephosphorylation   5 terms 
  Biochemical function     hydrolase activity     5 terms