PDBsum entry 2plv

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protein ligands Protein-protein interface(s) links
Virus PDB id
Protein chains
288 a.a. *
268 a.a. *
235 a.a. *
63 a.a. *
Waters ×479
* Residue conservation analysis
PDB id:
Name: Virus
Title: Structural factors that control conformational transitions a serotype specificity in type 3 poliovirus
Structure: Human poliovirus type 1 (subunit vp1). Chain: 1. Human poliovirus type 1 (subunit vp2). Chain: 2. Human poliovirus type 1 (subunit vp3). Chain: 3. Human poliovirus type 1 (subunit vp4). Chain: 4
Source: Human poliovirus 1. Organism_taxid: 12081. Strain: mahoney. Strain: mahoney
2.88Å     R-factor:   0.200    
Authors: D.J.Filman,J.M.Hogle
Key ref: D.J.Filman et al. (1989). Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus. EMBO J, 8, 1567-1579. PubMed id: 2548847
17-Oct-89     Release date:   17-Oct-89    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
P03300  (POLG_POL1M) -  Genome polyprotein
2209 a.a.
288 a.a.*
Protein chain
Pfam   ArchSchema ?
P03300  (POLG_POL1M) -  Genome polyprotein
2209 a.a.
268 a.a.
Protein chain
Pfam   ArchSchema ?
P03300  (POLG_POL1M) -  Genome polyprotein
2209 a.a.
235 a.a.*
Protein chain
Pfam   ArchSchema ?
P03300  (POLG_POL1M) -  Genome polyprotein
2209 a.a.
63 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 6 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class 2: Chains 1, 2, 3, 4: E.C.  - RNA-directed Rna polymerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Nucleoside triphosphate
+ RNA(n)
= diphosphate
+ RNA(n+1)
   Enzyme class 3: Chains 1, 2, 3, 4: E.C.  - Picornain 3C.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
   Enzyme class 4: Chains 1, 2, 3, 4: E.C.  - Picornain 2A.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
   Enzyme class 5: Chains 1, 2, 3, 4: E.C.  - Nucleoside-triphosphate phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: NTP + H2O = NDP + phosphate
+ H(2)O
+ phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     viral capsid   1 term 
  Biochemical function     structural molecule activity     1 term  


EMBO J 8:1567-1579 (1989)
PubMed id: 2548847  
Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus.
D.J.Filman, R.Syed, M.Chow, A.J.Macadam, P.D.Minor, J.M.Hogle.
The three-dimensional structure of the Sabin strain of type 3 poliovirus has been determined at 2.4 A resolution. Significant structural differences with the Mahoney strain of type 1 poliovirus are confined to loops and terminal extensions of the capsid proteins, occur in all of the major antigenic sites of the virion and typically involve insertions, deletions or the replacement of prolines. Several newly identified components of the structure participate in assembly-dependent interactions which are relevant to the biologically important processes of viral assembly and uncoating. These include two sites of lipid substitution, two putative nucleotides and a beta sheet formed by the N-termini of capsid proteins VP4 and VP1. The structure provides an explanation for the temperature sensitive phenotype of the P3/Sabin strain. Amino acids that regulate temperature sensitivity in type 3 poliovirus are located in the interfaces between promoters, in the binding site for a lipid substituent and in an assembly-dependent extended beta sheet that stabilizes the association of pentamers. Several lines of evidence indicate that these structural components also control conformational transitions at various stages of the viral life cycle.

Literature references that cite this PDB file's key reference

  PubMed id Reference
22388738 X.Wang, W.Peng, J.Ren, Z.Hu, J.Xu, Z.Lou, X.Li, W.Yin, X.Shen, C.Porta, T.S.Walter, G.Evans, D.Axford, R.Owen, D.J.Rowlands, J.Wang, D.I.Stuart, E.E.Fry, and Z.Rao (2012).
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.
  Nat Struct Mol Biol, 19, 424-429.
PDB codes: 3vbf 3vbh 3vbo 3vbr 3vbs 3vbu
21325720 A.Janner (2011).
Form, symmetry and packing of biomacromolecules. III. Antigenic, receptor and contact binding sites in picornaviruses.
  Acta Crystallogr A, 67, 174-189.  
20923881 M.G.Mateu (2011).
Virus engineering: functionalization and stabilization.
  Protein Eng Des Sel, 24, 53-63.  
20181687 H.C.Levy, M.Bostina, D.J.Filman, and J.M.Hogle (2010).
Catching a virus in the act of RNA release: a novel poliovirus uncoating intermediate characterized by cryo-electron microscopy.
  J Virol, 84, 4426-4441.
PDB codes: 3iyb 3iyc
  20397067 T.J.Tuthill, E.Groppelli, J.M.Hogle, and D.J.Rowlands (2010).
  Curr Top Microbiol Immunol, 343, 43-89.  
19124585 J.E.Mueller, M.Bessaud, Q.S.Huang, L.C.Martinez, P.A.Barril, V.Morel, J.Balanant, J.Bocacao, J.Hewitt, B.D.Gessner, F.Delpeyroux, and S.V.Nates (2009).
Environmental poliovirus surveillance during oral poliovirus vaccine and inactivated poliovirus vaccine use in Córdoba Province, Argentina.
  Appl Environ Microbiol, 75, 1395-1401.  
18596089 J.K.Odoom, Z.Yunus, G.Dunn, P.D.Minor, and J.Martín (2008).
Changes in population dynamics during long-term evolution of sabin type 1 poliovirus in an immunodeficient patient.
  J Virol, 82, 9179-9190.  
18480448 S.Khan, X.Peng, J.Yin, P.Zhang, and E.Wimmer (2008).
Characterization of the New World monkey homologues of human poliovirus receptor CD155.
  J Virol, 82, 7167-7179.  
17151123 R.Mateo, and M.G.Mateu (2007).
Deterministic, compensatory mutational events in the capsid of foot-and-mouth disease virus in response to the introduction of mutations found in viruses from persistent infections.
  J Virol, 81, 1879-1887.  
16843897 C.Meier, A.R.Aricescu, R.Assenberg, R.T.Aplin, R.J.Gilbert, J.M.Grimes, and D.I.Stuart (2006).
The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.
  Structure, 14, 1157-1165.
PDB code: 2cme
16972033 E.Dedepsidis, I.Karakasiliotis, E.Paximadi, Z.Kyriakopoulou, D.Komiotis, and P.Markoulatos (2006).
Detection of unusual mutation within the VP1 region of different re-isolates of poliovirus Sabin vaccine.
  Virus Genes, 33, 183-191.  
16501074 M.L.Yakovenko, E.A.Cherkasova, G.V.Rezapkin, O.E.Ivanova, A.P.Ivanov, T.P.Eremeeva, O.Y.Baykova, K.M.Chumakov, and V.I.Agol (2006).
Antigenic evolution of vaccine-derived polioviruses: changes in individual epitopes and relative stability of the overall immunological properties.
  J Virol, 80, 2641-2653.  
16868986 Y.Y.Ke, Y.C.Chen, and T.H.Lin (2006).
Structure of the virus capsid protein VP1 of enterovirus 71 predicted by some homology modeling and molecular docking studies.
  J Comput Chem, 27, 1556-1570.  
15596863 A.M.Milstone, J.Petrella, M.D.Sanchez, M.Mahmud, J.C.Whitbeck, and J.M.Bergelson (2005).
Interaction with coxsackievirus and adenovirus receptor, but not with decay-accelerating factor (DAF), induces A-particle formation in a DAF-binding coxsackievirus B3 isolate.
  J Virol, 79, 655-660.  
15919927 D.Bubeck, D.J.Filman, N.Cheng, A.C.Steven, J.M.Hogle, and D.M.Belnap (2005).
The structure of the poliovirus 135S cell entry intermediate at 10-angstrom resolution reveals the location of an externalized polypeptide that binds to membranes.
  J Virol, 79, 7745-7755.
PDB code: 1xyr
16188967 M.Arita, S.L.Zhu, H.Yoshida, T.Yoneyama, T.Miyamura, and H.Shimizu (2005).
A Sabin 3-derived poliovirus recombinant contained a sequence homologous with indigenous human enterovirus species C in the viral polymerase coding region.
  J Virol, 79, 12650-12657.  
16153180 O.M.Kew, R.W.Sutter, Gourville, W.R.Dowdle, and M.A.Pallansch (2005).
Vaccine-derived polioviruses and the endgame strategy for global polio eradication.
  Annu Rev Microbiol, 59, 587-635.  
15155227 A.L.Salvati, A.De Dominicis, S.Tait, A.Canitano, A.Lahm, and L.Fiore (2004).
Mechanism of action at the molecular level of the antiviral drug 3(2H)-isoflavene against type 2 poliovirus.
  Antimicrob Agents Chemother, 48, 2233-2243.  
15331736 C.Xiao, T.J.Tuthill, C.M.Bator Kelly, L.J.Challinor, P.R.Chipman, R.A.Killington, D.J.Rowlands, A.Craig, and M.G.Rossmann (2004).
Discrimination among rhinovirus serotypes for a variant ICAM-1 receptor molecule.
  J Virol, 78, 10034-10044.  
14990711 E.A.Hewat, and D.Blaas (2004).
Cryoelectron microscopy analysis of the structural changes associated with human rhinovirus type 14 uncoating.
  J Virol, 78, 2935-2942.  
14981262 J.Reguera, A.Carreira, L.Riolobos, J.M.Almendral, and M.G.Mateu (2004).
Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid.
  Proc Natl Acad Sci U S A, 101, 2724-2729.  
15006797 M.Chambon, C.Archimbaud, J.L.Bailly, J.M.Gourgand, F.Charbonné, and H.Peigue-Lafeuille (2004).
Virucidal efficacy of glutaraldehyde against enteroviruses is related to the location of lysine residues in exposed structures of the VP1 capsid protein.
  Appl Environ Microbiol, 70, 1717-1722.  
15016887 R.M.Ledford, N.R.Patel, T.M.Demenczuk, A.Watanyar, T.Herbertz, M.S.Collett, and D.C.Pevear (2004).
VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds.
  J Virol, 78, 3663-3674.  
15078968 S.Blomqvist, C.Savolainen, P.Laine, P.Hirttiö, E.Lamminsalo, E.Penttilä, S.Jöks, M.Roivainen, and T.Hovi (2004).
Characterization of a highly evolved vaccine-derived poliovirus type 3 isolated from sewage in Estonia.
  J Virol, 78, 4876-4883.  
15452226 Y.Zhang, A.A.Simpson, R.M.Ledford, C.M.Bator, S.Chakravarty, G.A.Skochko, T.M.Demenczuk, A.Watanyar, D.C.Pevear, and M.G.Rossmann (2004).
Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds.
  J Virol, 78, 11061-11069.
PDB codes: 1na1 1ncq 1ncr 1nd2 1nd3
12692248 E.E.Fry, N.J.Knowles, J.W.Newman, G.Wilsden, Z.Rao, A.M.King, and D.I.Stuart (2003).
Crystal structure of Swine vesicular disease virus and implications for host adaptation.
  J Virol, 77, 5475-5486.
PDB code: 1oop
12857761 R.Mateo, A.Díaz, E.Baranowski, and M.G.Mateu (2003).
Complete alanine scanning of intersubunit interfaces in a foot-and-mouth disease virus capsid reveals critical contributions of many side chains to particle stability and viral function.
  J Biol Chem, 278, 41019-41027.  
12663789 Y.He, S.Mueller, P.R.Chipman, C.M.Bator, X.Peng, V.D.Bowman, S.Mukhopadhyay, E.Wimmer, R.J.Kuhn, and M.G.Rossmann (2003).
Complexes of poliovirus serotypes with their common cellular receptor, CD155.
  J Virol, 77, 4827-4835.
PDB code: 1nn8
12097583 A.D.Stuart, T.A.McKee, P.A.Williams, C.Harley, S.Shen, D.I.Stuart, T.D.Brown, and S.M.Lea (2002).
Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection.
  J Virol, 76, 7694-7704.
PDB code: 1h8t
12121655 J.Ding, A.D.Smith, S.C.Geisler, X.Ma, G.F.Arnold, and E.Arnold (2002).
Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1.
  Structure, 10, 999.
PDB code: 1k5m
12142481 J.M.Hogle (2002).
Poliovirus cell entry: common structural themes in viral cell entry pathways.
  Annu Rev Microbiol, 56, 677-702.  
12368335 J.Martín, E.Samoilovich, G.Dunn, A.Lackenby, E.Feldman, A.Heath, E.Svirchevskaya, G.Cooper, M.Yermalovich, and P.D.Minor (2002).
Isolation of an intertypic poliovirus capsid recombinant from a child with vaccine-associated paralytic poliomyelitis.
  J Virol, 76, 10921-10928.  
11991962 J.Martín, and P.D.Minor (2002).
Characterization of CHAT and Cox type 1 live-attenuated poliovirus vaccine strains.
  J Virol, 76, 5339-5349.  
12147709 M.S.Smyth, and J.H.Martin (2002).
Picornavirus uncoating.
  Mol Pathol, 55, 214-219.  
12007645 P.C.McMinn (2002).
An overview of the evolution of enterovirus 71 and its clinical and public health significance.
  FEMS Microbiol Rev, 26, 91.  
11134308 A.Airaksinen, M.Roivainen, and T.Hovi (2001).
Coxsackievirus A9 VP1 mutants with enhanced or hindered A particle formation and decreased infectivity.
  J Virol, 75, 952-960.  
11581430 A.Varrasso, H.E.Drummer, J.A.Huang, R.A.Stevenson, N.Ficorilli, M.J.Studdert, and C.A.Hartley (2001).
Sequence conservation and antigenic variation of the structural proteins of equine rhinitis A virus.
  J Virol, 75, 10550-10556.  
11160747 C.Xiao, C.M.Bator, V.D.Bowman, E.Rieder, Y.He, B.Hébert, J.Bella, T.S.Baker, E.Wimmer, R.J.Kuhn, and M.G.Rossmann (2001).
Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1.
  J Virol, 75, 2444-2451.  
11689657 Q.Jia, J.M.Hogle, T.Hashikawa, and A.Nomoto (2001).
Molecular genetic analysis of revertants from a poliovirus mutant that is specifically adapted to the mouse spinal cord.
  J Virol, 75, 11766-11772.  
11333877 S.K.Tsang, B.M.McDermott, V.R.Racaniello, and J.M.Hogle (2001).
Kinetic analysis of the effect of poliovirus receptor on viral uncoating: the receptor as a catalyst.
  J Virol, 75, 4984-4989.  
10618373 D.M.Belnap, B.M.McDermott, D.J.Filman, N.Cheng, B.L.Trus, H.J.Zuccola, V.R.Racaniello, J.M.Hogle, and A.C.Steven (2000).
Three-dimensional structure of poliovirus receptor bound to poliovirus.
  Proc Natl Acad Sci U S A, 97, 73-78.  
10627545 D.M.Belnap, D.J.Filman, B.L.Trus, N.Cheng, F.P.Booy, J.F.Conway, S.Curry, C.N.Hiremath, S.K.Tsang, A.C.Steven, and J.M.Hogle (2000).
Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus.
  J Virol, 74, 1342-1354.  
11070012 H.M.Liu, D.P.Zheng, L.B.Zhang, M.S.Oberste, M.A.Pallansch, and O.M.Kew (2000).
Molecular evolution of a type 1 wild-vaccine poliovirus recombinant during widespread circulation in China.
  J Virol, 74, 11153-11161.  
10708414 J.Martín, G.Dunn, R.Hull, V.Patel, and P.D.Minor (2000).
Evolution of the Sabin strain of type 3 poliovirus in an immunodeficient patient during the entire 637-day period of virus excretion.
  J Virol, 74, 3001-3010.  
10644372 S.Hertzler, M.Luo, and H.L.Lipton (2000).
Mutation of predicted virion pit residues alters binding of Theiler's murine encephalomyelitis virus to BHK-21 cells.
  J Virol, 74, 1994-2004.  
10611281 A.T.Hadfield, G.D.Diana, and M.G.Rossmann (1999).
Analysis of three structurally related antiviral compounds in complex with human rhinovirus 16.
  Proc Natl Acad Sci U S A, 96, 14730-14735.
PDB codes: 1qju 1qjx 1qjy
  10595531 D.K.Phelps, and C.B.Post (1999).
Molecular dynamics investigation of the effect of an antiviral compound on human rhinovirus.
  Protein Sci, 8, 2281-2289.  
10647183 E.Hendry, H.Hatanaka, E.Fry, M.Smyth, J.Tate, G.Stanway, J.Santti, M.Maaronen, T.Hyypiä, and D.Stuart (1999).
The crystal structure of coxsackievirus A9: new insights into the uncoating mechanisms of enteroviruses.
  Structure, 7, 1527-1538.
PDB code: 1d4m
10092135 S.Kaminaka, Y.Imamura, M.Shingu, T.Kitagawa, and T.Toyoda (1999).
Studies of bovine enterovirus structure by ultraviolet resonance Raman spectroscopy.
  J Virol Methods, 77, 117-123.  
  9445074 C.Adami, A.E.Pritchard, T.Knauf, M.Luo, and H.L.Lipton (1998).
A determinant for central nervous system persistence localized in the capsid of Theiler's murine encephalomyelitis virus by using recombinant viruses.
  J Virol, 72, 1662-1665.  
9541542 D.Haydon, S.Lea, L.Fry, N.Knowles, A.R.Samuel, D.Stuart, and M.E.Woolhouse (1998).
Characterizing sequence variation in the VP1 capsid proteins of foot and mouth disease virus (serotype 0) with respect to virion structure.
  J Mol Evol, 46, 465-475.  
10089503 D.J.Filman, M.W.Wien, J.A.Cunningham, J.M.Bergelson, and J.M.Hogle (1998).
Structure determination of echovirus 1.
  Acta Crystallogr D Biol Crystallogr, 54, 1261-1272.
PDB code: 1ev1
9817841 M.Agbandje-McKenna, A.L.Llamas-Saiz, F.Wang, P.Tattersall, and M.G.Rossmann (1998).
Functional implications of the structure of the murine parvovirus, minute virus of mice.
  Structure, 6, 1369-1381.  
  9499072 M.Li, P.Beard, P.A.Estes, M.K.Lyon, and R.L.Garcea (1998).
Intercapsomeric disulfide bonds in papillomavirus assembly and disassembly.
  J Virol, 72, 2160-2167.  
  9696852 R.Basavappa, A.Gómez-Yafal, and J.M.Hogle (1998).
The poliovirus empty capsid specifically recognizes the poliovirus receptor and undergoes some, but not all, of the transitions associated with cell entry.
  J Virol, 72, 7551-7556.  
  9445020 W.Wang, W.M.Lee, A.G.Mosser, and R.R.Rueckert (1998).
WIN 52035-dependent human rhinovirus 16: assembly deficiency caused by mutations near the canyon surface.
  J Virol, 72, 1210-1218.  
9083115 A.T.Hadfield, W.Lee, R.Zhao, M.A.Oliveira, I.Minor, R.R.Rueckert, and M.G.Rossmann (1997).
The refined structure of human rhinovirus 16 at 2.15 A resolution: implications for the viral life cycle.
  Structure, 5, 427-441.
PDB code: 1aym
  9151866 A.W.Dove, and V.R.Racaniello (1997).
Cold-adapted poliovirus mutants bypass a postentry replication block.
  J Virol, 71, 4728-4735.  
9294865 D.Joseph-McCarthy, J.M.Hogle, and M.Karplus (1997).
Use of the multiple copy simultaneous search (MCSS) method to design a new class of picornavirus capsid binding drugs.
  Proteins, 29, 32-58.  
  9311861 M.M.Georgescu, J.Balanant, A.Macadam, D.Otelea, M.Combiescu, A.A.Combiescu, R.Crainic, and F.Delpeyroux (1997).
Evolution of the Sabin type 1 poliovirus in humans: characterization of strains isolated from patients with vaccine-associated paralytic poliomyelitis.
  J Virol, 71, 7758-7768.  
9253417 M.W.Wien, S.Curry, D.J.Filman, and J.M.Hogle (1997).
Structural studies of poliovirus mutants that overcome receptor defects.
  Nat Struct Biol, 4, 666-674.
PDB codes: 1al2 1ar6 1ar7 1ar8 1ar9 1asj
9122218 N.Vaidehi, and W.A.Goddard (1997).
The pentamer channel stiffening model for drug action on human rhinovirus HRV-1A.
  Proc Natl Acad Sci U S A, 94, 2466-2471.  
  9174174 P.J.Buontempo, S.Cox, J.Wright-Minogue, J.L.DeMartino, A.M.Skelton, E.Ferrari, R.Albin, E.J.Rozhon, V.Girijavallabhan, J.F.Modlin, and J.F.O'Connell (1997).
SCH 48973: a potent, broad-spectrum, antienterovirus compound.
  Antimicrob Agents Chemother, 41, 1220-1225.  
  9371640 S.Curry, E.Fry, W.Blakemore, R.Abu-Ghazaleh, T.Jackson, A.King, S.Lea, J.Newman, and D.Stuart (1997).
Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus.
  J Virol, 71, 9743-9752.  
  9371643 S.Liao, and V.Racaniello (1997).
Allele-specific adaptation of poliovirus VP1 B-C loop variants to mutant cell receptors.
  J Virol, 71, 9770-9777.  
8728646 L.Liljas (1996).
  Curr Opin Struct Biol, 6, 151-156.  
8712919 L.Piirainen, A.Airaksinen, T.Hovi, and M.Roivainen (1996).
Selective cleavage by trypsin of the capsid protein VP1 of type 3 poliovirus results in improved sorting of cell bound virions.
  Arch Virol, 141, 1011-1020.  
8805560 M.W.Wien, M.Chow, and J.M.Hogle (1996).
Poliovirus: new insights from an old paradigm.
  Structure, 4, 763-767.  
8805561 P.D.Minor (1996).
Poliovirus biology.
  Structure, 4, 775-778.  
8939746 R.Zhao, D.C.Pevear, M.J.Kremer, V.L.Giranda, J.A.Kofron, R.J.Kuhn, and M.G.Rossmann (1996).
Human rhinovirus 3 at 3.0 A resolution.
  Structure, 4, 1205-1220.
PDB code: 1rhi
8805520 S.Curry, E.Fry, W.Blakemore, R.Abu-Ghazaleh, T.Jackson, A.King, S.Lea, J.Newman, D.Rowlands, and D.Stuart (1996).
Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity.
  Structure, 4, 135-145.
PDB code: 4gh4
  8523541 T.Couderc, F.Delpeyroux, H.Le Blay, and B.Blondel (1996).
Mouse adaptation determinants of poliovirus type 1 enhance viral uncoating.
  J Virol, 70, 305-312.  
8876143 V.R.Racaniello (1996).
Early events in poliovirus infection: virus-receptor interactions.
  Proc Natl Acad Sci U S A, 93, 11378-11381.  
8805563 V.R.Racaniello (1996).
The poliovirus receptor: a hook, or an unzipper?
  Structure, 4, 769-773.  
  7983702 C.I.Nugent, and K.Kirkegaard (1995).
RNA binding properties of poliovirus subviral particles.
  J Virol, 69, 13-22.  
  7609049 E.M.Colston, and V.R.Racaniello (1995).
Poliovirus variants selected on mutant receptor-expressing cells identify capsid residues that expand receptor recognition.
  J Virol, 69, 4823-4829.  
7743132 J.A.Speir, S.Munshi, G.Wang, T.S.Baker, and J.E.Johnson (1995).
Structures of the native and swollen forms of cowpea chlorotic mottle virus determined by X-ray crystallography and cryo-electron microscopy.
  Structure, 3, 63-78.
PDB code: 1cwp
8591043 J.K.Muckelbauer, M.Kremer, I.Minor, G.Diana, F.J.Dutko, J.Groarke, D.C.Pevear, and M.G.Rossmann (1995).
The structure of coxsackievirus B3 at 3.5 A resolution.
  Structure, 3, 653-667.  
  7609067 M.J.Bouchard, D.H.Lam, and V.R.Racaniello (1995).
Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine.
  J Virol, 69, 4972-4978.  
7773791 M.Smyth, J.Tate, E.Hoey, C.Lyons, S.Martin, and D.Stuart (1995).
Implications for viral uncoating from the structure of bovine enterovirus.
  Nat Struct Biol, 2, 224-231.
PDB code: 1bev
  7609025 Z.Tu, N.M.Chapman, G.Hufnagel, S.Tracy, J.R.Romero, W.H.Barry, L.Zhao, K.Currey, and B.Shapiro (1995).
The cardiovirulent phenotype of coxsackievirus B3 is determined at a single site in the genomic 5' nontranslated region.
  J Virol, 69, 4607-4618.  
  7966611 A.G.Mosser, J.Y.Sgro, and R.R.Rueckert (1994).
Distribution of drug resistance mutations in type 3 poliovirus identifies three regions involved in uncoating functions.
  J Virol, 68, 8193-8201.  
  7813425 E.Colston, and V.R.Racaniello (1994).
Soluble receptor-resistant poliovirus mutants identify surface and internal capsid residues that control interaction with the cell receptor.
  EMBO J, 13, 5855-5862.  
7533301 L.Carrasco (1994).
Picornavirus inhibitors.
  Pharmacol Ther, 64, 215-290.  
  7849588 M.G.Rossmann (1994).
Viral cell recognition and entry.
  Protein Sci, 3, 1712-1725.  
8198437 N.M.Chapman, Z.Tu, S.Tracy, and C.J.Gauntt (1994).
An infectious cDNA copy of the genome of a non-cardiovirulent coxsackievirus B3 strain: its complete sequence analysis and comparison to the genomes of cardiovirulent coxsackieviruses.
  Arch Virol, 135, 115-130.  
8166674 P.W.Lee, and G.Leone (1994).
Reovirus protein sigma 1: from cell attachment to protein oligomerization and folding mechanisms.
  Bioessays, 16, 199-206.  
7820548 R.A.Grant, C.N.Hiremath, D.J.Filman, R.Syed, K.Andries, and J.M.Hogle (1994).
Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design.
  Curr Biol, 4, 784-797.
PDB codes: 1vba 1vbb 1vbc 1vbd 1vbe
  7849583 R.Basavappa, R.Syed, O.Flore, J.P.Icenogle, D.J.Filman, and J.M.Hogle (1994).
Role and mechanism of the maturation cleavage of VP0 in poliovirus assembly: structure of the empty capsid assembly intermediate at 2.9 A resolution.
  Protein Sci, 3, 1651-1669.
PDB code: 1pov
8081743 S.Lea, J.Hernández, W.Blakemore, E.Brocchi, S.Curry, E.Domingo, E.Fry, R.Abu-Ghazaleh, A.King, and J.Newman (1994).
The structure and antigenicity of a type C foot-and-mouth disease virus.
  Structure, 2, 123-139.
PDB code: 1fmd
  7966631 T.Couderc, N.Guédo, V.Calvez, I.Pelletier, J.Hogle, F.Colbère-Garapin, and B.Blondel (1994).
Substitutions in the capsids of poliovirus mutants selected in human neuroblastoma cells confer on the Mahoney type 1 strain a phenotype neurovirulent in mice.
  J Virol, 68, 8386-8391.  
  8382293 A.G.Mosser, and R.R.Rueckert (1993).
WIN 51711-dependent mutants of poliovirus type 3: evidence that virions decay after release from cells unless drug is present.
  J Virol, 67, 1246-1254.  
7915182 M.A.Oliveira, R.Zhao, W.M.Lee, M.J.Kremer, I.Minor, R.R.Rueckert, G.D.Diana, D.C.Pevear, F.J.Dutko, and M.A.McKinlay (1993).
The structure of human rhinovirus 16.
  Structure, 1, 51-68.
PDB codes: 1ayn 2rhn
8093643 N.H.Olson, P.R.Kolatkar, M.A.Oliveira, R.H.Cheng, J.M.Greve, A.McClelland, T.S.Baker, and M.G.Rossmann (1993).
Structure of a human rhinovirus complexed with its receptor molecule.
  Proc Natl Acad Sci U S A, 90, 507-511.  
  8389907 T.Couderc, J.Hogle, H.Le Blay, F.Horaud, and B.Blondel (1993).
Molecular characterization of mouse-virulent poliovirus type 1 Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell.
  J Virol, 67, 3808-3817.  
  1279196 B.P.Mahon, K.Katrak, and K.H.Mills (1992).
Antigenic sequences of poliovirus recognized by T cells: serotype-specific epitopes on VP1 and VP3 and cross-reactive epitopes on VP4 defined by using CD4+ T-cell clones.
  J Virol, 66, 7012-7020.  
  1310770 C.Reynolds, D.Birnby, and M.Chow (1992).
Folding and processing of the capsid protein precursor P1 is kinetically retarded in neutralization site 3B mutants of poliovirus.
  J Virol, 66, 1641-1648.  
1740191 C.U.Hellen, and E.Wimmer (1992).
The role of proteolytic processing in the morphogenesis of virus particles.
  Experientia, 48, 201-215.  
  1376134 J.A.McKeating, J.P.Moore, M.Ferguson, H.S.Marsden, S.Graham, J.W.Almond, D.J.Evans, and R.A.Weiss (1992).
Monoclonal antibodies to the C4 region of human immunodeficiency virus type 1 gp120: use in topological analysis of a CD4 binding site.
  AIDS Res Hum Retroviruses, 8, 451-459.  
  1376371 K.Wiegers, and R.Dernick (1992).
Molecular basis of antigenic structures of poliovirus: implications for their evolution during morphogenesis.
  J Virol, 66, 4597-4600.  
1528078 M.D.Walkinshaw (1992).
Protein targets for structure-based drug design.
  Med Res Rev, 12, 317-372.  
  1331497 N.Moscufo, and M.Chow (1992).
Myristate-protein interactions in poliovirus: interactions of VP4 threonine 28 contribute to the structural conformation of assembly intermediates and the stability of assembled virions.
  J Virol, 66, 6849-6857.  
1332036 V.L.Giranda, B.A.Heinz, M.A.Oliveira, I.Minor, K.H.Kim, P.R.Kolatkar, M.G.Rossmann, and R.R.Rueckert (1992).
Acid-induced structural changes in human rhinovirus 14: possible role in uncoating.
  Proc Natl Acad Sci U S A, 89, 10213-10217.  
  1654440 A.J.Macadam, G.Ferguson, C.Arnold, and P.D.Minor (1991).
An assembly defect as a result of an attenuating mutation in the capsid proteins of the poliovirus type 3 vaccine strain.
  J Virol, 65, 5225-5231.  
  1850692 E.G.Moss, and V.R.Racaniello (1991).
Host range determinants located on the interior of the poliovirus capsid.
  EMBO J, 10, 1067-1074.  
  1845893 J.J.Harber, J.Bradley, C.W.Anderson, and E.Wimmer (1991).
Catalysis of poliovirus VP0 maturation cleavage is not mediated by serine 10 of VP2.
  J Virol, 65, 326-334.  
  1850043 M.Equestre, D.Genovese, F.Cavalieri, L.Fiore, R.Santoro, and R.Perez Bercoff (1991).
Identification of a consistent pattern of mutations in neurovirulent variants derived from the sabin vaccine strain of poliovirus type 2.
  J Virol, 65, 2707-2710.  
  1847458 R.B.Ren, E.G.Moss, and V.R.Racaniello (1991).
Identification of two determinants that attenuate vaccine-related type 2 poliovirus.
  J Virol, 65, 1377-1382.  
1851992 S.Koike, I.Ise, and A.Nomoto (1991).
Functional domains of the poliovirus receptor.
  Proc Natl Acad Sci U S A, 88, 4104-4108.  
  1651227 T.O.Yeates, D.H.Jacobson, A.Martin, C.Wychowski, M.Girard, D.J.Filman, and J.M.Hogle (1991).
Three-dimensional structure of a mouse-adapted type 2/type 1 poliovirus chimera.
  EMBO J, 10, 2331-2341.  
  2157861 C.E.Fricks, and J.M.Hogle (1990).
Cell-induced conformational change in poliovirus: externalization of the amino terminus of VP1 is responsible for liposome binding.
  J Virol, 64, 1934-1945.  
  2166807 D.Marc, G.Masson, M.Girard, and S.van der Werf (1990).
Lack of myristoylation of poliovirus capsid polypeptide VP0 prevents the formation of virions or results in the assembly of noninfectious virus particles.
  J Virol, 64, 4099-4107.  
  2157900 H.G.Kräusslich, C.Hölscher, Q.Reuer, J.Harber, and E.Wimmer (1990).
Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity.
  J Virol, 64, 2433-2436.  
  2152812 K.Kirkegaard (1990).
Mutations in VP1 of poliovirus specifically affect both encapsidation and release of viral RNA.
  J Virol, 64, 195-206.  
  2164587 M.Gromeier, and K.Wetz (1990).
Kinetics of poliovirus uncoating in HeLa cells in a nonacidic environment.
  J Virol, 64, 3590-3597.  
  2166805 S.R.Compton, B.Nelsen, and K.Kirkegaard (1990).
Temperature-sensitive poliovirus mutant fails to cleave VP0 and accumulates provirions.
  J Virol, 64, 4067-4075.  
  2157045 W.M.Klump, I.Bergmann, B.C.Müller, D.Ameis, and R.Kandolf (1990).
Complete nucleotide sequence of infectious Coxsackievirus B3 cDNA: two initial 5' uridine residues are regained during plus-strand RNA synthesis.
  J Virol, 64, 1573-1583.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.