PDBsum entry: 2pf4

Hydrolase regulator/viral protein

PDB id: 2pf4

Contents

Protein chains

575 a.a. *

163 a.a. *

152 a.a. *

142 a.a. *

Metals

_ZN ×8

* Residue conservation analysis

PDB id:

2pf4

Name:

Hydrolase regulator/viral protein

Title:

Crystal structure of the full-length simian virus 40 small t complexed with the protein phosphatase 2a aalpha subunit

Structure:

Serine/threonine-protein phosphatase 2a 65 kda re subunit a alpha isoform. Chain: a, b, c, d. Synonym: pp2a, subunit a, pr65-alpha isoform, pp2a, subunit alpha isoform. Engineered: yes. Small t antigen. Chain: e, f, g, h. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: ppp2r1a. Expressed in: escherichia coli. Expression_system_taxid: 562. Simian virus 40. Organism_taxid: 10633. Strain: va45-54-2.

Resolution:

3.10Å R-factor: 0.247 R-free: 0.304

Authors:

U.Cho,S.Morrone,W.Xu

Key ref:

U.Cho et al. Crystal structure of the full-Length simian virus 40 small t antigen complexed with the protein phosphatase 2a aalpha subunit. To be published,

Date:

03-Apr-07 Release date: 07-Aug-07

Protein chains

Q76MZ3  (2AAA_MOUSE) -  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Seq: 589 a.a.

Struc: 575 a.a.

Protein chain

Q9W9P1  (Q9W9P1_SV40) -  Small tumor antigen

Seq: 174 a.a.

Struc: 163 a.a.

Protein chain

Q9W9P1  (Q9W9P1_SV40) -  Small tumor antigen

Seq: 174 a.a.

Struc: 152 a.a.

Protein chains

Q9W9P1  (Q9W9P1_SV40) -  Small tumor antigen

Seq: 174 a.a.

Struc: 142 a.a.

 Gene Ontology (GO) functional annotation 

• Cellular component: protein phosphatase type 2A complex (5 terms)
• Biological process: chromosome segregation (3 terms)
• Biochemical function: binding (7 terms)