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protein ligands metals Protein-protein interface(s) links
Protein binding/transferase PDB id
2ov2
Jmol
Contents
Protein chains
(+ 2 more) 178 a.a. *
34 a.a. *
35 a.a. *
33 a.a. *
Ligands
GCP ×8
EDO ×3
Metals
_CL ×8
_MG ×8
Waters ×1136
* Residue conservation analysis
PDB id:
2ov2
Name: Protein binding/transferase
Title: The crystal structure of the human rac3 in complex with the domain of human p21-activated kinase 4 (pak4)
Structure: Ras-related c3 botulinum toxin substrate 3. Chain: a, f, b, c, g, d, e, h. Synonym: rac3, p21-rac3. Engineered: yes. Serine/threonine-protein kinase pak 4. Chain: i, j, k, l, m, n, o, p. Fragment: crib domain. Synonym: pak4, p21-activated kinase 4, pak-4. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rac3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: pak4, kiaa1142.
Resolution:
2.10Å     R-factor:   0.174     R-free:   0.225
Authors: E.Ugochukwu,X.Yang,J.M.Elkins,N.Burgess-Brown,G.Bunkoczi, J.E.D.Debreczeni,M.Sundstrom,C.H.Arrowsmith,J.Weigelt,A.Edw F.Von Delft,S.Knapp,D.A.Doyle,Structural Genomics Consortiu
Key ref: E.Ugochukwu et al. The crystal structure of the human rac3 in complex with the crib domain of human p21-Activated kinase 4 (pak4). To be published,
Date:
12-Feb-07     Release date:   13-Mar-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P60763  (RAC3_HUMAN) -  Ras-related C3 botulinum toxin substrate 3
Seq:
Struc:
192 a.a.
178 a.a.*
Protein chains
Pfam   ArchSchema ?
O96013  (PAK4_HUMAN) -  Serine/threonine-protein kinase PAK 4
Seq:
Struc:
 
Seq:
Struc:
591 a.a.
34 a.a.
Protein chains
Pfam   ArchSchema ?
O96013  (PAK4_HUMAN) -  Serine/threonine-protein kinase PAK 4
Seq:
Struc:
 
Seq:
Struc:
591 a.a.
35 a.a.
Protein chain
Pfam   ArchSchema ?
O96013  (PAK4_HUMAN) -  Serine/threonine-protein kinase PAK 4
Seq:
Struc:
 
Seq:
Struc:
591 a.a.
33 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: Chains I, J, K, L, M, N, O, P: E.C.2.7.11.1  - Non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
=
ADP
Bound ligand (Het Group name = GCP)
matches with 78.79% similarity
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     intracellular   12 terms 
  Biological process     intracellular signal transduction   9 terms 
  Biochemical function     nucleotide binding     4 terms