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PDBsum entry 2ov2

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protein ligands metals Protein-protein interface(s) links
Protein binding/transferase PDB id
2ov2
Jmol
Contents
Protein chains
(+ 2 more) 178 a.a. *
34 a.a. *
35 a.a. *
33 a.a. *
Ligands
GCP ×8
EDO ×3
Metals
_CL ×8
_MG ×8
Waters ×1136
* Residue conservation analysis
PDB id:
2ov2
Name: Protein binding/transferase
Title: The crystal structure of the human rac3 in complex with the domain of human p21-activated kinase 4 (pak4)
Structure: Ras-related c3 botulinum toxin substrate 3. Chain: a, f, b, c, g, d, e, h. Synonym: rac3, p21-rac3. Engineered: yes. Serine/threonine-protein kinase pak 4. Chain: i, j, k, l, m, n, o, p. Fragment: crib domain. Synonym: pak4, p21-activated kinase 4, pak-4. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rac3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: pak4, kiaa1142.
Resolution:
2.10Å     R-factor:   0.174     R-free:   0.225
Authors: E.Ugochukwu,X.Yang,J.M.Elkins,N.Burgess-Brown,G.Bunkoczi, J.E.D.Debreczeni,M.Sundstrom,C.H.Arrowsmith,J.Weigelt,A.Edw F.Von Delft,S.Knapp,D.A.Doyle,Structural Genomics Consortiu
Key ref: E.Ugochukwu et al. The crystal structure of the human rac3 in complex with the crib domain of human p21-Activated kinase 4 (pak4). To be published, .
Date:
12-Feb-07     Release date:   13-Mar-07    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P60763  (RAC3_HUMAN) -  Ras-related C3 botulinum toxin substrate 3
Seq:
Struc:
192 a.a.
178 a.a.*
Protein chains
Pfam   ArchSchema ?
O96013  (PAK4_HUMAN) -  Serine/threonine-protein kinase PAK 4
Seq:
Struc:
 
Seq:
Struc:
591 a.a.
34 a.a.
Protein chains
Pfam   ArchSchema ?
O96013  (PAK4_HUMAN) -  Serine/threonine-protein kinase PAK 4
Seq:
Struc:
 
Seq:
Struc:
591 a.a.
35 a.a.
Protein chain
Pfam   ArchSchema ?
O96013  (PAK4_HUMAN) -  Serine/threonine-protein kinase PAK 4
Seq:
Struc:
 
Seq:
Struc:
591 a.a.
33 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: Chains I, J, K, L, M, N, O, P: E.C.2.7.11.1  - Non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
=
ADP
Bound ligand (Het Group name = GCP)
matches with 78.79% similarity
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell periphery   15 terms 
  Biological process     intracellular signal transduction   11 terms 
  Biochemical function     nucleotide binding     5 terms