PDBsum entry 2os6

Cell adhesion

PDB id: 2os6

Contents

Protein chain

89 a.a. *

Ligands

VAL-GLU-ASN-LYS-VAL-THR-ASP-LEU

* Residue conservation analysis

PDB id:

2os6

Name:

Cell adhesion

Title:

Solution structure of larg pdz domain in complex with c-terminal octa- peptide of plexin b1

Structure:

Rho guanine nucleotide exchange factor 12. Chain: a. Fragment: pdz domain. Synonym: larg protein, leukemia-associated rhogef. Engineered: yes. C-terminal peptide of plexin-b1. Chain: b. Synonym: semaphorin receptor sep. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence occurs naturally in humans

NMR struc:

20 models

Authors:

J.Liu,H.Huang,Y.Yang

Key ref:

J.Liu et al. Solution structure of the larg pdz domain in complex with c-Terminal peptide of plexin b1. To be published, .

Date:

05-Feb-07 Release date: 12-Feb-08

Protein chain

Q9NZN5  (ARHGC_HUMAN) -  Rho guanine nucleotide exchange factor 12 from Homo sapiens

Seq: 1544 a.a.

Struc: 89 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)