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PDBsum entry 2oqf

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protein Protein-protein interface(s) links
Hydrolase PDB id
2oqf
Jmol
Contents
Protein chains
124 a.a. *
Waters ×91
* Residue conservation analysis
PDB id:
2oqf
Name: Hydrolase
Title: Structure of a synthetic, non-natural analogue of rnase a: [ d83a]rnase a
Structure: Ribonuclease pancreatic. Chain: a, b, c, d. Synonym: rnase 1, rnase a. Engineered: yes. Mutation: yes
Source: Synthetic: yes. Other_details: combined solid phase peptide synthesis and n chemical ligation chemistries.
Resolution:
2.30Å     R-factor:   0.236     R-free:   0.291
Authors: D.J.Boerema,V.A.Tereshko,J.L.Zhang,C.He,S.B.H.Kent
Key ref: D.J.Boerema et al. Design, Synthesis, And characterization of non-Natural rnase a analogues with enhanced second-Step catalytic activity. To be published, .
Date:
31-Jan-07     Release date:   12-Feb-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P61823  (RNAS1_BOVIN) -  Ribonuclease pancreatic
Seq:
Struc:
150 a.a.
124 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.1.27.5  - Pancreatic ribonuclease.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   1 term 
  Biological process     metabolic process   3 terms 
  Biochemical function     protein binding     5 terms