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Hydrolase/hydrolase inhibitor
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PDB id
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2nqa
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase/hydrolase inhibitor
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Title:
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Catalytic domain of human calpain 8
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Structure:
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Calpain 8. Chain: a, b. Fragment: residues 23-346. Engineered: yes. Leupeptin inhibitor. Chain: d, e. Fragment: leupeptin inhibitor. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: loc388743. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: commercially available from sigma l2884
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Biol. unit:
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Tetramer (from
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Resolution:
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2.20Å
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R-factor:
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0.205
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R-free:
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0.268
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Authors:
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T.L.Davis,R.Paramanathan,C.Butler-Cole,P.J.Finerty Jr.,J.Wei M.Sundstrom,C.H.Arrowsmith,A.M.Edwards,A.Bochkarev,S.Dhe-Pa Structural Genomics Consortium (Sgc)
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Key ref:
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T.L.Davis
et al.
Structure of human calpain 8.
To be published,
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Date:
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30-Oct-06
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Release date:
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14-Nov-06
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PROCHECK
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Headers
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References
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P17655
(CAN2_HUMAN) -
Calpain-2 catalytic subunit
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Seq:
Struc:
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700 a.a.
310 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 83 residue positions (black
crosses)
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Gene Ontology (GO) functional annotation
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Cellular component
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intracellular
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1 term
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Biological process
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proteolysis
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1 term
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Biochemical function
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cysteine-type endopeptidase activity
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2 terms
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Links
