PDBsum entry 2npl

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protein links
Cell adhesion PDB id
Protein chain
96 a.a. *
* Residue conservation analysis
PDB id:
Name: Cell adhesion
Title: Nmr structure of card d2 domain
Structure: Coxsackievirus and adenovirus receptor. Chain: x. Fragment: domain car 2. Synonym: coxsackievirus b- adenovirus receptor. Hcar. Cvb3- binding protein. Hcvadr. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cxadr, car. Expressed in: escherichia coli. Expression_system_taxid: 562.
NMR struc: 1 models
Authors: S.Jiang,M.Caffrey
Key ref:
S.Jiang and M.Caffrey (2007). Solution structure of the coxsackievirus and adenovirus receptor domain 2. Protein Sci, 16, 539-542. PubMed id: 17322536 DOI: 10.1110/ps.062643507
27-Oct-06     Release date:   13-Mar-07    
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Protein chain
Pfam   ArchSchema ?
P78310  (CXAR_HUMAN) -  Coxsackievirus and adenovirus receptor
365 a.a.
96 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)


DOI no: 10.1110/ps.062643507 Protein Sci 16:539-542 (2007)
PubMed id: 17322536  
Solution structure of the coxsackievirus and adenovirus receptor domain 2.
S.Jiang, M.Caffrey.
The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus and adenovirus. CAR possesses an extracellular region that is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the present work, the solution structure of CAR-D2, consisting of residues 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is shown to be a beta-sandwich motif comprised of two beta-sheets, which are stabilized by two disulfide bonds. The first beta-sheet is comprised of beta-strands A, B, and E, and the second beta-sheet is comprised of beta-strands C, F, and G. A relatively hydrophobic helix is found between beta-strands C and E, which replaces beta-strand D of the classical c-type immunoglobulin fold.
  Selected figure(s)  
Figure 2.
Figure 2. Model for the mechanism of CAR. The CAR--D1 domains are colored blue and green and the CAR--D2 domains are colored
  The above figure is reprinted by permission from the Protein Society: Protein Sci (2007, 16, 539-542) copyright 2007.  
  Figure was selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
20813955 P.Verdino, D.A.Witherden, W.L.Havran, and I.A.Wilson (2010).
The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K.
  Science, 329, 1210-1214.
PDB codes: 3mj6 3mj7
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