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PDBsum entry 2mys

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protein ligands metals links
Muscle protein PDB id
2mys
Jmol
Contents
Protein chains
800 a.a. *
138 a.a.* *
134 a.a.* *
Ligands
SO4
Metals
_MG
* Residue conservation analysis
* C-alpha coords only
PDB id:
2mys
Name: Muscle protein
Title: Myosin subfragment-1, alpha carbon coordinates only for the two light chains
Structure: Myosin. Chain: a. Fragment: subfragment-1. Other_details: proteolytic fragment of myosin generated by papain digestion. Myosin. Chain: b. Fragment: subfragment-1. Other_details: proteolytic fragment of myosin generated by
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: skeletal. Tissue: pectoralis muscle. Tissue: pectoralis muscle
Biol. unit: Hexamer (from PDB file)
Resolution:
2.80Å     R-factor:   0.223    
Authors: I.Rayment,H.M.Holden
Key ref: I.Rayment et al. (1993). Three-dimensional structure of myosin subfragment-1: a molecular motor. Science, 261, 50-58. PubMed id: 8316857 DOI: 10.1126/science.8316857
Date:
27-Jun-96     Release date:   11-Jan-97    
Supersedes: 1mys
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P13538  (MYSS_CHICK) -  Myosin heavy chain, skeletal muscle, adult
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1939 a.a.
800 a.a.*
Protein chain
Pfam  
P02609  (MLRS_CHICK) -  Myosin regulatory light chain 2, skeletal muscle isoform
Seq:
Struc:
168 a.a.
138 a.a.*
Protein chain
Pfam  
P02604  (MLE1_CHICK) -  Myosin light chain 1, skeletal muscle isoform
Seq:
Struc:
192 a.a.
134 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 73 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     myosin complex   1 term 
  Biochemical function     metal ion binding     4 terms  

 

 
    Added reference    
 
 
DOI no: 10.1126/science.8316857 Science 261:50-58 (1993)
PubMed id: 8316857  
 
 
Three-dimensional structure of myosin subfragment-1: a molecular motor.
I.Rayment, W.R.Rypniewski, K.Schmidt-Bäse, R.Smith, D.R.Tomchick, M.M.Benning, D.A.Winkelmann, G.Wesenberg, H.M.Holden.
 
  ABSTRACT  
 
Directed movement is a characteristic of many living organisms and occurs as a result of the transformation of chemical energy into mechanical energy. Myosin is one of three families of molecular motors that are responsible for cellular motility. The three-dimensional structure of the head portion of myosin, or subfragment-1, which contains both the actin and nucleotide binding sites, is described. This structure of a molecular motor was determined by single crystal x-ray diffraction. The data provide a structural framework for understanding the molecular basis of motility.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23250061 W.A.Hendrickson (2013).
Evolution of diffraction methods for solving crystal structures.
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21326200 C.Veigel, and C.F.Schmidt (2011).
Moving into the cell: single-molecule studies of molecular motors in complex environments.
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21415352 F.I.Malik, J.J.Hartman, K.A.Elias, B.P.Morgan, H.Rodriguez, K.Brejc, R.L.Anderson, S.H.Sueoka, K.H.Lee, J.T.Finer, R.Sakowicz, R.Baliga, D.R.Cox, M.Garard, G.Godinez, R.Kawas, E.Kraynack, D.Lenzi, P.P.Lu, A.Muci, C.Niu, X.Qian, D.W.Pierce, M.Pokrovskii, I.Suehiro, S.Sylvester, T.Tochimoto, C.Valdez, W.Wang, T.Katori, D.A.Kass, Y.T.Shen, S.F.Vatner, and D.J.Morgans (2011).
Cardiac myosin activation: a potential therapeutic approach for systolic heart failure.
  Science, 331, 1439-1443.  
21149681 J.H.Brown, V.S.Kumar, E.O'Neall-Hennessey, L.Reshetnikova, H.Robinson, M.Nguyen-McCarty, A.G.Szent-Györgyi, and C.Cohen (2011).
Visualizing key hinges and a potential major source of compliance in the lever arm of myosin.
  Proc Natl Acad Sci U S A, 108, 114-119.
PDB code: 3pn7
20938697 J.Tilsner, K.Amari, and L.Torrance (2011).
Plasmodesmata viewed as specialised membrane adhesion sites.
  Protoplasma, 248, 39-60.  
21482782 M.Reconditi, E.Brunello, M.Linari, P.Bianco, T.Narayanan, P.Panine, G.Piazzesi, V.Lombardi, and M.Irving (2011).
Motion of myosin head domains during activation and force development in skeletal muscle.
  Proc Natl Acad Sci U S A, 108, 7236-7240.  
20824688 N.Cohen-Hadar, S.Lagziel-Simis, Y.Wine, F.Frolow, and A.Freeman (2011).
Re-structuring protein crystals porosity for biotemplating by chemical modification of lysine residues.
  Biotechnol Bioeng, 108, 1.  
21428964 S.Pathmanathan, E.Hamilton, E.Atcheson, and D.J.Timson (2011).
The interaction of IQGAPs with calmodulin-like proteins.
  Biochem Soc Trans, 39, 694-699.  
20824272 V.Caorsi, D.S.Ushakov, T.G.West, N.Setta-Kaffetzi, and M.A.Ferenczi (2011).
FRET characterisation for cross-bridge dynamics in single-skinned rigor muscle fibres.
  Eur Biophys J, 40, 13-27.  
  21463317 W.Y.Chu, J.Chen, R.X.Zhou, F.L.Zhao, T.Meng, D.X.Chen, X.X.Nong, Z.Liu, S.Q.Lu, and J.S.Zhang (2011).
Characterization and ontogenetic expression analysis of the myosin light chains from the fast white muscle of mandarin fish Siniperca chuatsi.
  J Fish Biol, 78, 1225-1238.  
20386496 A.Doroszko, D.Polewicz, V.J.Cadete, J.Sawicka, M.Jones, D.Szczesna-Cordary, P.Y.Cheung, and G.Sawicki (2010).
Neonatal asphyxia induces the nitration of cardiac myosin light chain 2 that is associated with cardiac systolic dysfunction.
  Shock, 34, 592-600.  
20711642 A.Kengyel, W.A.Wolf, R.L.Chisholm, and J.R.Sellers (2010).
Nonmuscle myosin IIA with a GFP fused to the N-terminus of the regulatory light chain is regulated normally.
  J Muscle Res Cell Motil, 31, 163-170.  
20801044 A.Málnási-Csizmadia, and M.Kovács (2010).
Emerging complex pathways of the actomyosin powerstroke.
  Trends Biochem Sci, 35, 684-690.  
21152002 C.D.Williams, M.Regnier, and T.L.Daniel (2010).
Axial and radial forces of cross-bridges depend on lattice spacing.
  PLoS Comput Biol, 6, e1001018.  
21151434 D.I.Markov, E.O.Zubov, O.P.Nikolaeva, B.I.Kurganov, and D.I.Levitsky (2010).
Thermal denaturation and aggregation of Myosin subfragment 1 isoforms with different essential light chains.
  Int J Mol Sci, 11, 4194-4226.  
20035030 G.Y.Wang, C.C.Yeh, B.C.Jensen, M.J.Mann, P.C.Simpson, and A.J.Baker (2010).
Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive.
  Am J Physiol Heart Circ Physiol, 298, H913-H920.  
20192767 H.L.Sweeney, and A.Houdusse (2010).
Structural and functional insights into the Myosin motor mechanism.
  Annu Rev Biophys, 39, 539-557.  
19880375 H.Shishido, K.Nakazato, E.Katayama, S.Chaen, and S.Maruta (2010).
Kinesin-Calmodulin fusion protein as a molecular shuttle.
  J Biochem, 147, 213-223.  
20094053 J.A.Spudich, and S.Sivaramakrishnan (2010).
Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis.
  Nat Rev Mol Cell Biol, 11, 128-137.  
20459085 J.J.Frye, V.A.Klenchin, C.R.Bagshaw, and I.Rayment (2010).
Insights into the importance of hydrogen bonding in the gamma-phosphate binding pocket of myosin: structural and functional studies of serine 236.
  Biochemistry, 49, 4897-4907.
PDB codes: 3myh 3myk 3myl
20080738 J.M.Laakso, J.H.Lewis, H.Shuman, and E.M.Ostap (2010).
Control of myosin-I force sensing by alternative splicing.
  Proc Natl Acad Sci U S A, 107, 698-702.  
20399183 M.Cecchini, Y.Alexeev, and M.Karplus (2010).
Pi release from myosin: a simulation analysis of possible pathways.
  Structure, 18, 458-470.  
20855589 M.J.Greenberg, K.Kazmierczak, D.Szczesna-Cordary, and J.R.Moore (2010).
Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry.
  Proc Natl Acad Sci U S A, 107, 17403-17408.  
20616041 M.Lorenz, and K.C.Holmes (2010).
The actin-myosin interface.
  Proc Natl Acad Sci U S A, 107, 12529-12534.  
20385833 M.Takano, T.P.Terada, and M.Sasai (2010).
Unidirectional Brownian motion observed in an in silico single molecule experiment of an actomyosin motor.
  Proc Natl Acad Sci U S A, 107, 7769-7774.  
20471271 R.E.McConnell, and M.J.Tyska (2010).
Leveraging the membrane - cytoskeleton interface with myosin-1.
  Trends Cell Biol, 20, 418-426.  
20399184 R.Tehver, and D.Thirumalai (2010).
Rigor to post-rigor transition in myosin V: link between the dynamics and the supporting architecture.
  Structure, 18, 471-481.  
20606261 S.Lara-González, J.J.Birktoft, and C.L.Lawson (2010).
Structure of the Escherichia coli RNA polymerase alpha subunit C-terminal domain.
  Acta Crystallogr D Biol Crystallogr, 66, 806-812.
PDB code: 3k4g
  20844746 S.Wu, J.Liu, M.C.Reedy, R.T.Tregear, H.Winkler, C.Franzini-Armstrong, H.Sasaki, C.Lucaveche, Y.E.Goldman, M.K.Reedy, and K.A.Taylor (2010).
Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions.
  PLoS One, 5, 0.
PDB codes: 2w49 2w4a 2w4g 2w4t
20226094 T.P.Burghardt, K.L.Neff, E.D.Wieben, and K.Ajtai (2010).
Myosin individualized: single nucleotide polymorphisms in energy transduction.
  BMC Genomics, 11, 172.  
20071392 T.Uno, T.Moriwaki, Y.Isoyama, Y.Uno, K.Kanamaru, H.Yamagata, M.Nakamura, and M.Takagi (2010).
Rab14 from Bombyx mori (Lepidoptera: Bombycidae) shows ATPase activity.
  Biol Lett, 6, 379-381.  
20385845 V.Nucciotti, C.Stringari, L.Sacconi, F.Vanzi, L.Fusi, M.Linari, G.Piazzesi, V.Lombardi, and F.S.Pavone (2010).
Probing myosin structural conformation in vivo by second-harmonic generation microscopy.
  Proc Natl Acad Sci U S A, 107, 7763-7768.  
20192763 W.Yang (2010).
Lessons learned from UvrD helicase: mechanism for directional movement.
  Annu Rev Biophys, 39, 367-385.  
19217860 A.Radocaj, T.Weiss, W.I.Helsby, B.Brenner, and T.Kraft (2009).
Force-generating cross-bridges during ramp-shaped releases: evidence for a new structural state.
  Biophys J, 96, 1430-1446.  
19506759 A.W.Serohijos, D.Tsygankov, S.Liu, T.C.Elston, and N.V.Dokholyan (2009).
Multiscale approaches for studying energy transduction in dynein.
  Phys Chem Chem Phys, 11, 4840-4850.  
19948121 B.Colombini, M.Nocella, G.Benelli, G.Cecchi, P.J.Griffiths, and M.A.Bagni (2009).
Reversal of the myosin power stroke induced by fast stretching of intact skeletal muscle fibers.
  Biophys J, 97, 2922-2929.  
19651039 B.Seebohm, F.Matinmehr, J.Köhler, A.Francino, F.Navarro-Lopéz, A.Perrot, C.Ozcelik, W.J.McKenna, B.Brenner, and T.Kraft (2009).
Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.
  Biophys J, 97, 806-824.  
18980659 C.D.Leasure, E.Fiume, and J.C.Fletcher (2009).
The essential gene EMB1611 maintains shoot apical meristem function during Arabidopsis development.
  Plant J, 57, 579-592.  
19108638 D.A.Patel, and D.D.Root (2009).
Close proximity of myosin loop 3 to troponin determined by triangulation of resonance energy transfer distance measurements.
  Biochemistry, 48, 357-369.  
19416073 D.D.Thomas, D.Kast, and V.L.Korman (2009).
Site-directed spectroscopic probes of actomyosin structural dynamics.
  Annu Rev Biophys, 38, 347-369.  
19804726 D.Hyatt, R.Cooke, and E.Pate (2009).
Analysis of the interaction of the nucleotide base with myosin and the effect on substrate efficacy.
  Biophys J, 97, 1952-1960.  
19769984 D.M.Himmel, S.Mui, E.O'Neall-Hennessey, A.G.Szent-Györgyi, and C.Cohen (2009).
The on-off switch in regulated myosins: different triggers but related mechanisms.
  J Mol Biol, 394, 496-505.
PDB codes: 3jtd 3jvt
18945678 G.Bajaj, Y.Zhang, M.I.Schimerlik, A.M.Hau, J.Yang, T.M.Filtz, C.Kioussi, and J.E.Ishmael (2009).
N-methyl-D-aspartate receptor subunits are non-myosin targets of myosin regulatory light chain.
  J Biol Chem, 284, 1252-1266.  
19408946 K.Ajtai, M.F.Halstead, M.Nyitrai, A.R.Penheiter, Y.Zheng, and T.P.Burghardt (2009).
The myosin C-loop is an allosteric actin contact sensor in actomyosin.
  Biochemistry, 48, 5263-5275.  
19955408 K.Ito, Y.Yamaguchi, K.Yanase, Y.Ichikawa, and K.Yamamoto (2009).
Unique charge distribution in surface loops confers high velocity on the fast motor protein Chara myosin.
  Proc Natl Acad Sci U S A, 106, 21585-21590.  
19361417 K.Kazmierczak, Y.Xu, M.Jones, G.Guzman, O.M.Hernandez, W.G.Kerrick, and D.Szczesna-Cordary (2009).
The role of the N-terminus of the myosin essential light chain in cardiac muscle contraction.
  J Mol Biol, 387, 706-725.  
19470801 K.Pant, J.Watt, M.Greenberg, M.Jones, D.Szczesna-Cordary, and J.R.Moore (2009).
Removal of the cardiac myosin regulatory light chain increases isometric force production.
  FASEB J, 23, 3571-3580.  
18929571 M.J.Greenberg, J.D.Watt, M.Jones, K.Kazmierczak, D.Szczesna-Cordary, and J.R.Moore (2009).
Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics.
  J Mol Cell Cardiol, 46, 108-115.  
19458282 M.J.Greenberg, T.R.Mealy, J.D.Watt, M.Jones, D.Szczesna-Cordary, and J.R.Moore (2009).
The molecular effects of skeletal muscle myosin regulatory light chain phosphorylation.
  Am J Physiol Regul Integr Comp Physiol, 297, R265-R274.  
19695097 R.M.Couñago, M.Davlieva, U.Strych, R.E.Hill, and K.L.Krause (2009).
Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames).
  BMC Struct Biol, 9, 53.
PDB code: 3ha1
19966224 R.V.Agafonov, I.V.Negrashov, Y.V.Tkachev, S.E.Blakely, M.A.Titus, D.D.Thomas, and Y.E.Nesmelov (2009).
Structural dynamics of the myosin relay helix by time-resolved EPR and FRET.
  Proc Natl Acad Sci U S A, 106, 21625-21630.  
19106098 S.B.Scruggs, A.C.Hinken, A.Thawornkaiwong, J.Robbins, L.A.Walker, P.P.de Tombe, D.L.Geenen, P.M.Buttrick, and R.J.Solaro (2009).
Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation.
  J Biol Chem, 284, 5097-5106.  
19635597 S.Ni, F.Hong, P.D.Brewer, M.Ikebe, H.Onishi, J.E.Baker, K.C.Facemyer, and C.R.Cremo (2009).
Kinetic and motor functions mediated by distinct regions of the regulatory light chain of smooth muscle myosin.
  Biochim Biophys Acta, 1794, 1599-1605.  
19127992 T.P.Burghardt, J.Li, and K.Ajtai (2009).
Single myosin lever arm orientation in a muscle fiber detected with photoactivatable GFP.
  Biochemistry, 48, 754-765.  
  19382535 T.S.Wong, B.Brough, and C.M.Ho (2009).
Creation of functional micro/nano systems through top-down and bottom-up approaches.
  Mol Cell Biomech, 6, 1.  
18987303 W.G.Kerrick, K.Kazmierczak, Y.Xu, Y.Wang, and D.Szczesna-Cordary (2009).
Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice.
  FASEB J, 23, 855-865.  
19756531 Z.Song, K.J.Parker, I.Enoh, H.Zhao, and O.Olubajo (2009).
Myosin-catalyzed ATP hydrolysis elucidated by 31P NMR kinetic studies and 1H PFG-diffusion measurements.
  Anal Bioanal Chem, 395, 1453-1459.  
19506755 d.e.l. .R.Jackson, and J.E.Baker (2009).
The energetics of allosteric regulation of ADP release from myosin heads.
  Phys Chem Chem Phys, 11, 4808-4814.  
18621839 A.C.Knowles, R.E.Ferguson, B.D.Brandmeier, Y.B.Sun, D.R.Trentham, and M.Irving (2008).
Orientation of the essential light chain region of myosin in relaxed, active, and rigor muscle.
  Biophys J, 95, 3882-3891.  
18957515 A.J.Engler, C.Carag-Krieger, C.P.Johnson, M.Raab, H.Y.Tang, D.W.Speicher, J.W.Sanger, J.M.Sanger, and D.E.Discher (2008).
Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating.
  J Cell Sci, 121, 3794-3802.  
18805936 A.R.Thompson, N.Naber, C.Wilson, R.Cooke, and D.D.Thomas (2008).
Structural dynamics of the actomyosin complex probed by a bifunctional spin label that cross-links SH1 and SH2.
  Biophys J, 95, 5238-5246.  
18544034 D.M.Milewicz, D.C.Guo, V.Tran-Fadulu, A.L.Lafont, C.L.Papke, S.Inamoto, C.S.Kwartler, and H.Pannu (2008).
Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction.
  Annu Rev Genomics Hum Genet, 9, 283-302.  
19325814 E.Grazi (2008).
Water and muscle contraction.
  Int J Mol Sci, 9, 1435-1452.  
18480297 E.P.Debold, S.E.Beck, and D.M.Warshaw (2008).
Effect of low pH on single skeletal muscle myosin mechanics and kinetics.
  Am J Physiol Cell Physiol, 295, C173-C179.  
18599626 F.Q.Zhao, R.Padrón, and R.Craig (2008).
Blebbistatin stabilizes the helical order of myosin filaments by promoting the switch 2 closed state.
  Biophys J, 95, 3322-3329.  
19325803 H.Tajsharghi (2008).
Thick and thin filament gene mutations in striated muscle diseases.
  Int J Mol Sci, 9, 1259-1275.  
18234833 I.Adamovic, S.M.Mijailovich, and M.Karplus (2008).
The elastic properties of the structurally characterized myosin II S2 subdomain: a molecular dynamics and normal mode analysis.
  Biophys J, 94, 3779-3789.  
19325727 I.Aprodu, A.Redaelli, and M.Soncini (2008).
Actomyosin interaction: mechanical and energetic properties in different nucleotide binding States.
  Int J Mol Sci, 9, 1927-1943.  
18211842 J.A.Spudich (2008).
Molecular motors: a surprising twist in myosin VI translocation.
  Curr Biol, 18, R68-R70.  
18725645 J.C.Klein, A.R.Burr, B.Svensson, D.J.Kennedy, J.Allingham, M.A.Titus, I.Rayment, and D.D.Thomas (2008).
Actin-binding cleft closure in myosin II probed by site-directed spin labeling and pulsed EPR.
  Proc Natl Acad Sci U S A, 105, 12867-12872.  
18931255 J.F.Beausang, H.W.Schroeder, P.C.Nelson, and Y.E.Goldman (2008).
Twirling of actin by myosins II and V observed via polarized TIRF in a modified gliding assay.
  Biophys J, 95, 5820-5831.  
18155233 J.H.Brown, Y.Yang, L.Reshetnikova, S.Gourinath, D.Süveges, J.Kardos, F.Hóbor, R.Reutzel, L.Nyitray, and C.Cohen (2008).
An unstable head-rod junction may promote folding into the compact off-state conformation of regulated myosins.
  J Mol Biol, 375, 1434-1443.
PDB codes: 3bas 3bat
18588896 K.P.Littlefield, A.B.Ward, J.S.Chappie, M.K.Reedy, S.I.Bernstein, R.A.Milligan, and M.C.Reedy (2008).
Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles.
  J Mol Biol, 381, 519-528.  
18951904 L.Alamo, W.Wriggers, A.Pinto, F.Bártoli, L.Salazar, F.Q.Zhao, R.Craig, and R.Padrón (2008).
Three-dimensional reconstruction of tarantula myosin filaments suggests how phosphorylation may regulate myosin activity.
  J Mol Biol, 384, 780-797.
PDB code: 3dtp
18326487 L.Liu, R.Srikakulam, and D.A.Winkelmann (2008).
Unc45 activates Hsp90-dependent folding of the myosin motor domain.
  J Biol Chem, 283, 13185-13193.  
18704171 M.Cecchini, A.Houdusse, and M.Karplus (2008).
Allosteric communication in myosin V: from small conformational changes to large directed movements.
  PLoS Comput Biol, 4, e1000129.  
18568345 M.J.Harris, and H.J.Woo (2008).
Energetics of subdomain movements and fluorescence probe solvation environment change in ATP-bound myosin.
  Eur Biophys J, 38, 1.  
18523008 M.Lord, T.E.Sladewski, and T.D.Pollard (2008).
Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells.
  Proc Natl Acad Sci U S A, 105, 8014-8019.  
18757874 M.Rusu, S.Birmanns, and W.Wriggers (2008).
Biomolecular pleiomorphism probed by spatial interpolation of coarse models.
  Bioinformatics, 24, 2460-2466.  
18552179 M.Sun, M.B.Rose, S.K.Ananthanarayanan, D.J.Jacobs, and C.M.Yengo (2008).
Characterization of the pre-force-generation state in the actomyosin cross-bridge cycle.
  Proc Natl Acad Sci U S A, 105, 8631-8636.  
18598361 N.Walter, and C.L.Holweg (2008).
Head-neck domain of Arabidopsis myosin XI, MYA2, fused with GFP produces F-actin patterns that coincide with fast organelle streaming in different plant cells.
  BMC Plant Biol, 8, 74.  
17960418 O.Andruchov, and S.Galler (2008).
Influence of fast and slow alkali myosin light chain isoforms on the kinetics of stretch-induced force transients of fast-twitch type IIA fibres of rat.
  Pflugers Arch, 455, 1165-1172.  
19109888 R.S.Williams, G.J.Williams, and J.A.Tainer (2008).
A charged performance by gp17 in viral packaging.
  Cell, 135, 1169-1171.  
18478096 R.Srikakulam, L.Liu, and D.A.Winkelmann (2008).
Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain.
  PLoS ONE, 3, e2137.  
18765799 R.V.Agafonov, Y.E.Nesmelov, M.A.Titus, and D.D.Thomas (2008).
Muscle and nonmuscle myosins probed by a spin label at equivalent sites in the force-generating domain.
  Proc Natl Acad Sci U S A, 105, 13397-13402.  
18971336 S.Iwai, and T.Q.Uyeda (2008).
Visualizing myosin-actin interaction with a genetically-encoded fluorescent strain sensor.
  Proc Natl Acad Sci U S A, 105, 16882-16887.  
18494798 S.Ortiz-Costa, M.M.Sorenson, and M.Sola-Penna (2008).
Betaine protects urea-induced denaturation of myosin subfragment-1.
  FEBS J, 275, 3388-3396.  
18587628 S.Pathmanathan, S.F.Elliott, S.McSwiggen, B.Greer, P.Harriott, G.B.Irvine, and D.J.Timson (2008).
IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B.
  Mol Cell Biochem, 318, 43-51.  
18375581 T.J.Herron, E.J.Devaney, and J.M.Metzger (2008).
Modulation of cardiac performance by motor protein gene transfer.
  Ann N Y Acad Sci, 1123, 96.  
19325791 T.Mitsui, and H.Ohshima (2008).
Remarks on muscle contraction mechanism.
  Int J Mol Sci, 9, 872-904.  
18397183 T.Richter, M.Floetenmeyer, C.Ferguson, J.Galea, J.Goh, M.R.Lindsay, G.P.Morgan, B.J.Marsh, and R.G.Parton (2008).
High-resolution 3D quantitative analysis of caveolar ultrastructure and caveola-cytoskeleton interactions.
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A closer look at energy transduction in muscle.
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Reductive methylation to improve crystallization of the putative oxidoreductase Rv0765c from Mycobacterium tuberculosis.
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A model of stereocilia adaptation based on single molecule mechanical studies of myosin I.
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Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.
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Molecular dynamics analysis of structural factors influencing back door pi release in myosin.
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Fifty years of contractility research post sliding filament hypothesis.
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Structure of a kinesin microtubule depolymerization machine.
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PDB code: 1ry6
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Type IV pilus structure and bacterial pathogenicity.
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The sliding filament model: 1972-2004.
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Myosin VI: cellular functions and motor properties.
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The myofibrillar complex and fatigue: a review.
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The structure of the vertebrate striated muscle thin filament: a tribute to the contributions of Jean Hanson.
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10679365 T.Yanagida, K.Kitamura, H.Tanaka, A.Hikikoshi Iwane, and S.Esaki (2000).
Single molecule analysis of the actomyosin motor.
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10836497 T.Yanagida, S.Esaki, A.H.Iwane, Y.Inoue, A.Ishijima, K.Kitamura, H.Tanaka, and M.Tokunaga (2000).
Single-motor mechanics and models of the myosin motor.
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11007486 W.M.Shih, Z.Gryczynski, J.R.Lakowicz, and J.A.Spudich (2000).
A FRET-based sensor reveals large ATP hydrolysis-induced conformational changes and three distinct states of the molecular motor myosin.
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10694391 X.D.Li, J.Saito, R.Ikebe, K.Mabuchi, and M.Ikebe (2000).
The interaction between the regulatory light chain domains on two heads is critical for regulation of smooth muscle myosin.
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10338210 A.Houdusse, V.N.Kalabokis, D.Himmel, A.G.Szent-Györgyi, and C.Cohen (1999).
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Cell, 97, 459-470.
PDB code: 1b7t
10094549 A.R.Janecke, M.Meins, M.Sadeghi, K.Grundmann, E.Apfelstedt-Sylla, E.Zrenner, T.Rosenberg, and A.Gal (1999).
Twelve novel myosin VIIA mutations in 34 patients with Usher syndrome type I: confirmation of genetic heterogeneity.
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10545368 B.Brenner, T.Kraft, L.C.Yu, and J.M.Chalovich (1999).
Thin filament activation probed by fluorescence of N-((2-(Iodoacetoxy)ethyl)-N-methyl)amino-7-nitrobenz-2-oxa-1, 3-diazole-labeled troponin I incorporated into skinned fibers of rabbit psoas muscle
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10427096 C.A.Shelton, J.C.Carter, G.C.Ellis, and B.Bowerman (1999).
The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenorhabditis elegans embryogenesis.
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10545173 C.M.Yengo, L.Chrin, A.S.Rovner, and C.L.Berger (1999).
Intrinsic tryptophan fluorescence identifies specific conformational changes at the actomyosin interface upon actin binding and ADP release.
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10090768 C.T.Murphy, and J.A.Spudich (1999).
The sequence of the myosin 50-20K loop affects Myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity.
  Biochemistry, 38, 3785-3792.  
10423443 C.Xu, R.Craig, L.Tobacman, R.Horowitz, and W.Lehman (1999).
Tropomyosin positions in regulated thin filaments revealed by cryoelectron microscopy.
  Biophys J, 77, 985-992.  
9916031 E.A.Bobkova, A.A.Bobkov, D.I.Levitsky, and E.Reisler (1999).
Effects of SH1 and SH2 modifications on myosin: similarities and differences.
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10508775 G.Stubbs (1999).
Developments in fiber diffraction.
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10494851 J.Müller, A.Marx, S.Sack, Y.H.Song, and E.Mandelkow (1999).
The structure of the nucleotide-binding site of kinesin.
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10571184 K.A.Taylor, H.Schmitz, M.C.Reedy, Y.E.Goldman, C.Franzini-Armstrong, H.Sasaki, R.T.Tregear, K.Poole, C.Lucaveche, R.J.Edwards, L.F.Chen, H.Winkler, and M.K.Reedy (1999).
Tomographic 3D reconstruction of quick-frozen, Ca2+-activated contracting insect flight muscle.
  Cell, 99, 421-431.  
10350461 K.Ajtai, Y.M.Peyser, S.Park, T.P.Burghardt, and A.Muhlrad (1999).
Trinitrophenylated reactive lysine residue in myosin detects lever arm movement during the consecutive steps of ATP hydrolysis.
  Biochemistry, 38, 6428-6440.  
  10493582 K.Kirshenbaum, M.Young, and S.Highsmith (1999).
Predicting allosteric switches in myosins.
  Protein Sci, 8, 1806-1815.  
9890887 K.Nakashima, H.Ishida, S.Y.Ohki, K.Hikichi, and M.Yazawa (1999).
Calcium binding induces interaction between the N- and C-terminal domains of yeast calmodulin and modulates its overall conformation.
  Biochemistry, 38, 98.  
10872464 M.A.Geeves, and K.C.Holmes (1999).
Structural mechanism of muscle contraction.
  Annu Rev Biochem, 68, 687-728.  
10089339 M.Kobayashi, M.Kubota, and Y.Matsuura (1999).
Crystallization and improvement of crystal quality for x-ray diffraction of maltooligosyl trehalose synthase by reductive methylation of lysine residues.
  Acta Crystallogr D Biol Crystallogr, 55, 931-933.  
  10493576 M.Young, K.Kirshenbaum, K.A.Dill, and S.Highsmith (1999).
Predicting conformational switches in proteins.
  Protein Sci, 8, 1752-1764.  
17030326 N.Errington, O.Byron, and A.J.Rowe (1999).
Conformational spectra--probing protein conformational changes.
  Biophys Chem, 80, 189-197.  
10029542 O.A.Andreev, L.D.Saraswat, S.Lowey, C.Slaughter, and J.Borejdo (1999).
Interaction of the N-terminus of chicken skeletal essential light chain 1 with F-actin.
  Biochemistry, 38, 2480-2485.  
10563488 P.S.Andersen, O.Havndrup, H.Bundgaard, L.A.Larsen, J.Vuust, K.Kjeldsen, and M.Christiansen (1999).
Adult-onset familial hypertrophic cardiomyopathy caused by a novel mutation, R694C, in the MYH7 gene.
  Clin Genet, 56, 244-246.  
10531021 R.Cooke (1999).
Myosin structure: does the tail wag the dog?
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10611679 R.D.Vale (1999).
Millennial musings on molecular motors.
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10202143 R.M.Cripps, J.A.Suggs, and S.I.Bernstein (1999).
Assembly of thick filaments and myofibrils occurs in the absence of the myosin head.
  EMBO J, 18, 1793-1804.  
10220335 R.T.McKay, B.P.Tripet, J.R.Pearlstone, L.B.Smillie, and B.D.Sykes (1999).
Defining the region of troponin-I that binds to troponin-C.
  Biochemistry, 38, 5478-5489.  
9927691 R.Vemuri, E.B.Lankford, K.Poetter, S.Hassanzadeh, K.Takeda, Z.X.Yu, V.J.Ferrans, and N.D.Epstein (1999).
The stretch-activation response may be critical to the proper functioning of the mammalian heart.
  Proc Natl Acad Sci U S A, 96, 1048-1053.  
10066911 S.Fujita, T.Nawata, and K.Yamada (1999).
Fluorescence changes of a label attached near the myosin active site on nucleotide binding in rat skeletal muscle fibres.
  J Physiol, 515, 869-880.  
10413484 S.Ramachandran, and D.D.Thomas (1999).
Rotational dynamics of the regulatory light chain in scallop muscle detected by time-resolved phosphorescence anisotropy.
  Biochemistry, 38, 9097-9104.  
10231357 S.Sack, F.J.Kull, and E.Mandelkow (1999).
Motor proteins of the kinesin family. Structures, variations, and nucleotide binding sites.
  Eur J Biochem, 262, 1.  
10704189 T.B.Friedman, J.R.Sellers, and K.B.Avraham (1999).
Unconventional myosins and the genetics of hearing loss.
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10613897 T.Wendt, D.Taylor, T.Messier, K.M.Trybus, and K.A.Taylor (1999).
Visualization of head-head interactions in the inhibited state of smooth muscle myosin.
  J Cell Biol, 147, 1385-1390.  
10085296 W.A.Kronert, A.Acebes, A.Ferrús, and S.I.Bernstein (1999).
Specific myosin heavy chain mutations suppress troponin I defects in Drosophila muscles.
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10406961 Y.M.Peyser, and A.Muhlrad (1999).
Actin and nucleotide induced conformational changes in the vicinity of Lys553 in myosin subfragment 1.
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9484957 A.B.Metcalf (1998).
Immunolocalization of myosin Ibeta in the hair cell's hair bundle.
  Cell Motil Cytoskeleton, 39, 159-165.  
9458041 A.Ishijima, H.Kojima, T.Funatsu, M.Tokunaga, H.Higuchi, H.Tanaka, and T.Yanagida (1998).
Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin.
  Cell, 92, 161-171.  
9657680 A.L.Friedman, M.A.Geeves, D.J.Manstein, and J.A.Spudich (1998).
Kinetic characterization of myosin head fragments with long-lived myosin.ATP states.
  Biochemistry, 37, 9679-9687.  
9887959 A.M.Lauzon, K.M.Trybus, and D.M.Warshaw (1998).
Molecular mechanics of two smooth muscle heavy meromyosin constructs that differ by an insert in the motor domain.
  Acta Physiol Scand, 164, 357-361.  
  9799259 A.M.Rushforth, C.C.White, and P.Anderson (1998).
Functions of the Caenorhabditis elegans regulatory myosin light chain genes mlc-1 and mlc-2.
  Genetics, 150, 1067-1077.  
9763625 A.S.Khromov, A.V.Somlyo, and A.P.Somlyo (1998).
Thiophosphorylation of myosin light chain increases rigor stiffness of rabbit smooth muscle.
  J Physiol, 512, 345-350.  
9860947 B.O.Carragher, N.Cheng, Z.Y.Wang, E.D.Korn, A.Reilein, D.M.Belnap, J.A.Hammer, and A.C.Steven (1998).
Structural invariance of constitutively active and inactive mutants of acanthamoeba myosin IC bound to F-actin in the rigor and ADP-bound states.
  Proc Natl Acad Sci U S A, 95, 15206-15211.  
  9691038 B.Patterson (1998).
Intragenic suppressors of Dictyostelium myosin G680 mutants demarcate discrete structural elements. Implications for conformational states of the motor.
  Genetics, 149, 1799-1807.  
9707415 C.Davies, R.B.Gerstner, D.E.Draper, V.Ramakrishnan, and S.W.White (1998).
The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif.
  EMBO J, 17, 4545-4558.  
9789020 C.M.Yengo, P.M.Fagnant, L.Chrin, A.S.Rovner, and C.L.Berger (1998).
Smooth muscle myosin mutants containing a single tryptophan reveal molecular interactions at the actin-binding interface.
  Proc Natl Acad Sci U S A, 95, 12944-12949.  
9635762 C.Sabido-David, B.Brandmeier, J.S.Craik, J.E.Corrie, D.R.Trentham, and M.Irving (1998).
Steady-state fluorescence polarization studies of the orientation of myosin regulatory light chains in single skeletal muscle fibers using pure isomers of iodoacetamidotetramethylrhodamine.
  Biophys J, 74, 3083-3092.  
9578557 C.T.Murphy, and J.A.Spudich (1998).
Dictyostelium myosin 25-50K loop substitutions specifically affect ADP release rates.
  Biochemistry, 37, 6738-6744.  
9653135 D.M.Warshaw, E.Hayes, D.Gaffney, A.M.Lauzon, J.Wu, G.Kennedy, K.Trybus, S.Lowey, and C.Berger (1998).
Myosin conformational states determined by single fluorophore polarization.
  Proc Natl Acad Sci U S A, 95, 8034-8039.  
9826617 E.B.Getz, R.Cooke, and S.L.Lehman (1998).
Phase transition in force during ramp stretches of skeletal muscle.
  Biophys J, 75, 2971-2983.  
9591671 E.Burmeister Getz, R.Cooke, and P.R.Selvin (1998).
Luminescence resonance energy transfer measurements in myosin.
  Biophys J, 74, 2451-2458.  
9449337 E.Pate, K.Franks-Skiba, and R.Cooke (1998).
Depletion of phosphate in active muscle fibers probes actomyosin states within the powerstroke.
  Biophys J, 74, 369-380.  
9852149 F.Buss, J.Kendrick-Jones, C.Lionne, A.E.Knight, G.P.Côté, and J.Paul Luzio (1998).
The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation.
  J Cell Biol, 143, 1535-1545.  
9521782 F.J.van de Loo, and M.E.Salvucci (1998).
Involvement of two aspartate residues of Rubisco activase in coordination of the ATP gamma-phosphate and subunit cooperativity.
  Biochemistry, 37, 4621-4625.  
9501981 F.Kozielski, I.Arnal, and R.H.Wade (1998).
A model of the microtubule-kinesin complex based on electron cryomicroscopy and X-ray crystallography.
  Curr Biol, 8, 191-198.  
9787775 G.Goldspink (1998).
Selective gene expression during adaptation of muscle in response to different physiological demands.
  Comp Biochem Physiol B Biochem Mol Biol, 120, 5.  
9601027 G.Wu, A.Wong, F.Qian, and R.C.Lu (1998).
Phosphorylation changes the spatial relationship between Glu124-Arg143 and Cys18 and Cys165 of the regulatory light chain in smooth muscle myosin.
  Biochemistry, 37, 7676-7685.  
9538695 H.E.Huxley (1998).
Getting to grips with contraction: the interplay of structure and biochemistry.
  Trends Biochem Sci, 23, 84-87.  
9512041 H.Iwamoto (1998).
Thin filament cooperativity as a major determinant of shortening velocity in skeletal muscle fibers.
  Biophys J, 74, 1452-1464.  
9618467 H.Onishi, S.Kojima, K.Katoh, K.Fujiwara, H.M.Martinez, and M.F.Morales (1998).
Functional transitions in myosin: formation of a critical salt-bridge and transmission of effect to the sensitive tryptophan.
  Proc Natl Acad Sci U S A, 95, 6653-6658.  
  9594535 H.P.Vosberg (1998).
[Genetic causes of hypertrophic cardiomyopathy]
  Med Klin (Munich), 93, 252-259.  
9746529 H.Tanaka, A.Ishijima, M.Honda, K.Saito, and T.Yanagida (1998).
Orientation dependence of displacements by a single one-headed myosin relative to the actin filament.
  Biophys J, 75, 1886-1894.  
  9560408 J.D.Huang, M.J.Cope, V.Mermall, M.C.Strobel, J.Kendrick-Jones, L.B.Russell, M.S.Mooseker, N.G.Copeland, and N.A.Jenkins (1998).
Molecular genetic dissection of mouse unconventional myosin-VA: head region mutations.
  Genetics, 148, 1951-1961.  
9531555 J.D.Jontes, E.M.Ostap, T.D.Pollard, and R.A.Milligan (1998).
Three-dimensional structure of Acanthamoeba castellanii myosin-IB (MIB) determined by cryoelectron microscopy of decorated actin filaments.
  J Cell Biol, 141, 155-162.  
9811855 J.H.Zang, and J.A.Spudich (1998).
Myosin II localization during cytokinesis occurs by a mechanism that does not require its motor domain.
  Proc Natl Acad Sci U S A, 95, 13652-13657.  
9449336 J.R.Patel, G.M.Diffee, X.P.Huang, and R.L.Moss (1998).
Phosphorylation of myosin regulatory light chain eliminates force-dependent changes in relaxation rates in skeletal muscle.
  Biophys J, 74, 360-368.  
9808035 K.C.Holmes (1998).
Picture story. A powerful stroke.
  Nat Struct Biol, 5, 940-942.  
9853018 K.Jostarndt-Fögen, A.Puntschart, H.Hoppeler, and R.Billeter (1998).
Fibre-type specific expression of fast and slow essential myosin light chain mRNAs in trained human skeletal muscles.
  Acta Physiol Scand, 164, 299-308.  
9533706 L.Eligula, L.Chuang, M.L.Phillips, M.Motoki, K.Seguro, and A.Muhlrad (1998).
Transglutaminase-induced cross-linking between subdomain 2 of G-actin and the 636-642 lysine-rich loop of myosin subfragment 1.
  Biophys J, 74, 953-963.  
9843439 L.K.Nitao, and E.Reisler (1998).
Probing the conformational states of the SH1-SH2 helix in myosin: a cross-linking approach.
  Biochemistry, 37, 16704-16710.  
9609698 L.Xie, and M.Schoenberg (1998).
Binding of SH1-SH2-modified myosin subfragment-1 to actin.
  Biochemistry, 37, 8048-8053.  
9572846 M.Furch, M.A.Geeves, and D.J.Manstein (1998).
Modulation of actin affinity and actomyosin adenosine triphosphatase by charge changes in the myosin motor domain.
  Biochemistry, 37, 6317-6326.  
9722650 M.Gerstein, and W.Krebs (1998).
A database of macromolecular motions.
  Nucleic Acids Res, 26, 4280-4290.  
9748336 M.Ikebe, M.Yamada, K.Mabuchi, T.Kambara, and R.Ikebe (1998).
A specific amino acid sequence at the head-rod junction is not critical for the phosphorylation-dependent regulation of smooth muscle myosin.
  Biochemistry, 37, 13285-13290.  
9860965 M.Xiao, H.Li, G.E.Snyder, R.Cooke, R.G.Yount, and P.R.Selvin (1998).
Conformational changes between the active-site and regulatory light chain of myosin as determined by luminescence resonance energy transfer: the effect of nucleotides and actin.
  Proc Natl Acad Sci U S A, 95, 15309-15314.  
9922150 O.A.Andreev, D.S.Ushakov, and J.Borejdo (1998).
Effect of ADP on binding of skeletal S1 to F-actin.
  Biochemistry, 37, 17836-17842.  
9772169 O.Roopnarine, A.G.Szent-Györgyi, and D.D.Thomas (1998).
Microsecond rotational dynamics of spin-labeled myosin regulatory light chain induced by relaxation and contraction of scallop muscle.
  Biochemistry, 37, 14428-14436.  
9700160 R.C.Stevens, and T.N.Davis (1998).
Mlc1p is a light chain for the unconventional myosin Myo2p in Saccharomyces cerevisiae.
  J Cell Biol, 142, 711-722.  
9501153 R.Cooke (1998).
New angle on myosin.
  Proc Natl Acad Sci U S A, 95, 2720-2722.  
9741621 R.Dominguez, Y.Freyzon, K.M.Trybus, and C.Cohen (1998).
Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state.
  Cell, 94, 559-571.
PDB codes: 1br1 1br2 1br4
9585577 R.R.Biekofsky, S.R.Martin, J.P.Browne, P.M.Bayley, and J.Feeney (1998).
Ca2+ coordination to backbone carbonyl oxygen atoms in calmodulin and other EF-hand proteins: 15N chemical shifts as probes for monitoring individual-site Ca2+ coordination.
  Biochemistry, 37, 7617-7629.  
9730814 R.T.McKay, J.R.Pearlstone, D.C.Corson, S.M.Gagné, L.B.Smillie, and B.D.Sykes (1998).
Structure and interaction site of the regulatory domain of troponin-C when complexed with the 96-148 region of troponin-I.
  Biochemistry, 37, 12419-12430.
PDB code: 1blq
9635763 S.C.Hopkins, C.Sabido-David, J.E.Corrie, M.Irving, and Y.E.Goldman (1998).
Fluorescence polarization transients from rhodamine isomers on the myosin regulatory light chain in skeletal muscle fibers.
  Biophys J, 74, 3093-3110.  
9472039 S.H.Lillie, and S.S.Brown (1998).
Smy1p, a kinesin-related protein that does not require microtubules.
  J Cell Biol, 140, 873-883.  
9512042 S.Highsmith, K.Duignan, K.Franks-Skiba, K.Polosukhina, and R.Cooke (1998).
Reversible inactivation of myosin subfragment 1 activity by mechanical immobilization.
  Biophys J, 74, 1465-1472.  
9512013 S.Xu, L.C.Yu, and M.Schoenberg (1998).
Behavior of N-phenylmaleimide-reacted muscle fibers in magnesium-free rigor solution.
  Biophys J, 74, 1110-1114.  
9585528 T.Hiratsuka (1998).
Prodan fluorescence reflects differences in nucleotide-induced conformational states in the myosin head and allows continuous visualization of the ATPase reactions.
  Biochemistry, 37, 7167-7176.  
9609697 T.P.Burghardt, S.P.Garamszegi, S.Park, and K.Ajtai (1998).
Tertiary structural changes in the cleft containing the ATP sensitive tryptophan and reactive thiol are consistent with pivoting of the myosin heavy chain at Gly699.
  Biochemistry, 37, 8035-8047.  
9675167 W.Wriggers, and K.Schulten (1998).
Nucleotide-dependent movements of the kinesin motor domain predicted by simulated annealing.
  Biophys J, 75, 646-661.  
9618466 X.Sun, A.L.Bognar, E.N.Baker, and C.A.Smith (1998).
Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase.
  Proc Natl Acad Sci U S A, 95, 6647-6652.
PDB code: 1fgs
9428702 A.Bartegi, C.Roustan, A.Chavanieu, R.Kassab, and A.Fattoum (1997).
Interaction of F-actin with synthetic peptides spanning the loop region of human cardiac beta-myosin heavy chain containing Arg403.
  Eur J Biochem, 250, 484-491.  
9223289 A.D.Mehta, J.T.Finer, and J.A.Spudich (1997).
Detection of single-molecule interactions using correlated thermal diffusion.
  Proc Natl Acad Sci U S A, 94, 7927-7931.  
9305951 A.M.Gulick, C.B.Bauer, J.B.Thoden, and I.Rayment (1997).
X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain.
  Biochemistry, 36, 11619-11628.
PDB codes: 1mma 1mmg 1mmn
9230689 A.M.Gulick, and I.Rayment (1997).
Structural studies on myosin II: communication between distant protein domains.
  Bioessays, 19, 561-569.  
9275176 B.Adhikari, K.Hideg, and P.G.Fajer (1997).
Independent mobility of catalytic and regulatory domains of myosin heads.
  Proc Natl Acad Sci U S A, 94, 9643-9647.  
9057826 B.C.Phan, Y.M.Peyser, E.Reisler, and A.Muhlrad (1997).
Effect of complexes of ADP and phosphate analogs on the conformation of the Cys707-Cys697 region of myosin subfragment 1.
  Eur J Biochem, 243, 636-642.  
  9263923 C.Reggiani, E.J.Potma, R.Bottinelli, M.Canepari, M.A.Pellegrino, and G.J.Stienen (1997).
Chemo-mechanical energy transduction in relation to myosin isoform composition in skeletal muscle fibres of the rat.
  J Physiol, 502, 449-460.  
9341208 C.Smyczynski, and A.A.Kasprzak (1997).
Effect of nucleotides and actin on the orientation of the light chain-binding domain in myosin subfragment 1.
  Biochemistry, 36, 13201-13207.  
9251811 D.Eden, and S.Highsmith (1997).
Light chain-dependent myosin structural dynamics in solution investigated by transient electrical birefringence.
  Biophys J, 73, 952-958.  
9171833 D.Weil, P.Küssel, S.Blanchard, G.Lévy, F.Levi-Acobas, M.Drira, H.Ayadi, and C.Petit (1997).
The autosomal recessive isolated deafness, DFNB2, and the Usher 1B syndrome are allelic defects of the myosin-VIIA gene.
  Nat Genet, 16, 191-193.  
9083682 E.Homsher, J.Lacktis, and M.Regnier (1997).
Strain-dependent modulation of phosphate transients in rabbit skeletal muscle fibers.
  Biophys J, 72, 1780-1791.  
9315852 E.Pate, N.Naber, M.Matuska, K.Franks-Skiba, and R.Cooke (1997).
Opening of the myosin nucleotide triphosphate binding domain during the ATPase cycle.
  Biochemistry, 36, 12155-12166.  
9428521 F.Kozielski, S.Sack, A.Marx, M.Thormählen, E.Schönbrunn, V.Biou, A.Thompson, E.M.Mandelkow, and E.Mandelkow (1997).
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Cell, 91, 985-994.
PDB code: 3kin
9244295 G.Woehlke, A.K.Ruby, C.L.Hart, B.Ly, N.Hom-Booher, and R.D.Vale (1997).
Microtubule interaction site of the kinesin motor.
  Cell, 90, 207-216.  
9092805 H.Onishi, M.F.Morales, S.Kojima, K.Katoh, and K.Fujiwara (1997).
Functional transitions in myosin: role of highly conserved Gly and Glu residues in the active site.
  Biochemistry, 36, 3767-3772.  
9348286 H.Schmitz, M.C.Reedy, M.K.Reedy, R.T.Tregear, and K.A.Taylor (1997).
Tomographic three-dimensional reconstruction of insect flight muscle partially relaxed by AMPPNP and ethylene glycol.
  J Cell Biol, 139, 695-707.  
9159126 I.Sase, H.Miyata, S.Ishiwata, and K.Kinosita (1997).
Axial rotation of sliding actin filaments revealed by single-fluorophore imaging.
  Proc Natl Acad Sci U S A, 94, 5646-5650.  
9348285 J.D.Jontes, and R.A.Milligan (1997).
Brush border myosin-I structure and ADP-dependent conformational changes revealed by cryoelectron microscopy and image analysis.
  J Cell Biol, 139, 683-693.  
9405612 J.D.Jontes, R.A.Milligan, T.D.Pollard, and E.M.Ostap (1997).
Kinetic characterization of brush border myosin-I ATPase.
  Proc Natl Acad Sci U S A, 94, 14332-14337.  
9094325 J.M.Squire (1997).
Architecture and function in the muscle sarcomere.
  Curr Opin Struct Biol, 7, 247-257.  
9214290 K.C.Giese, and J.A.Spudich (1997).
Phenotypically selected mutations in myosin's actin binding domain demonstrate intermolecular contacts important for motor function.
  Biochemistry, 36, 8465-8473.  
9105042 K.D.Becker, K.R.Gottshall, R.Hickey, J.C.Perriard, and K.R.Chien (1997).
Point mutations in human beta cardiac myosin heavy chain have differential effects on sarcomeric structure and assembly: an ATP binding site change disrupts both thick and thin filaments, whereas hypertrophic cardiomyopathy mutations display normal assembly.
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9305989 K.Polosukhina, and S.Highsmith (1997).
Kinetic investigation of the ligand dependence of rabbit skeletal muscle myosin subfragment 1 Cys-697 and Cys-707 reactivities.
  Biochemistry, 36, 11952-11958.  
8990166 M.Sata, W.F.Stafford, K.Mabuchi, and M.Ikebe (1997).
The motor domain and the regulatory domain of myosin solely dictate enzymatic activity and phosphorylation-dependent regulation, respectively.
  Proc Natl Acad Sci U S A, 94, 91-96.  
8994589 M.Suzuki, J.Shigematsu, Y.Fukunishi, Y.Harada, T.Yanagida, and T.Kodama (1997).
Coupling of protein surface hydrophobicity change to ATP hydrolysis by myosin motor domain.
  Biophys J, 72, 18-23.  
9245400 N.Naber, R.Cooke, and E.Pate (1997).
Binding of ncd to microtubules induces a conformational change near the junction of the motor domain with the neck.
  Biochemistry, 36, 9681-9689.  
9200683 P.D.Moens, and C.G.dos Remedios (1997).
A conformational change in F-actin when myosin binds: fluorescence resonance energy transfer detects an increase in the radial coordinate of Cys-374.
  Biochemistry, 36, 7353-7360.  
9238011 R.Mendelson, and E.P.Morris (1997).
The structure of the acto-myosin subfragment 1 complex: results of searches using data from electron microscopy and x-ray crystallography.
  Proc Natl Acad Sci U S A, 94, 8533-8538.
PDB code: 1alm
9348284 S.A.Burgess, M.L.Walker, H.D.White, and J.Trinick (1997).
Flexibility within myosin heads revealed by negative stain and single-particle analysis.
  J Cell Biol, 139, 675-681.  
9047298 S.Highsmith (1997).
Myosin regulatory light chain and nucleotide modulation of actin binding site electric charge.
  Biochemistry, 36, 2010-2016.  
9251806 S.Ishiwata, M.Miki, I.Shin, T.Funatsu, K.Yasuda, and C.G.dos Remedios (1997).
Interhead distances in myosin attached to F-actin estimated by fluorescence energy transfer spectroscopy.
  Biophys J, 73, 895-904.  
9370427 S.Malinchik, S.Xu, and L.C.Yu (1997).
Temperature-induced structural changes in the myosin thick filament of skinned rabbit psoas muscle.
  Biophys J, 73, 2304-2312.  
9116016 S.Park, K.Ajtai, and T.P.Burghardt (1997).
Mechanism for coupling free energy in ATPase to the myosin active site.
  Biochemistry, 36, 3368-3372.  
9370426 S.Xu, S.Malinchik, D.Gilroy, T.Kraft, B.Brenner, and L.C.Yu (1997).
X-ray diffraction studies of cross-bridges weakly bound to actin in relaxed skinned fibers of rabbit psoas muscle.
  Biophys J, 73, 2292-2303.  
9186010 T.Hasson, J.Walsh, J.Cable, M.S.Mooseker, S.D.Brown, and K.P.Steel (1997).
Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression.
  Cell Motil Cytoskeleton, 37, 127-138.  
9182663 T.Hasson, P.G.Gillespie, J.A.Garcia, R.B.MacDonald, Y.Zhao, A.G.Yee, M.S.Mooseker, and D.P.Corey (1997).
Unconventional myosins in inner-ear sensory epithelia.
  J Cell Biol, 137, 1287-1307.  
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Unconventional myosins, the basis for deafness in mouse and man.
  Am J Hum Genet, 61, 801-805.  
9275174 T.P.Burghardt, S.P.Garamszegi, and K.Ajtai (1997).
Probes bound to myosin Cys-707 rotate during length transients in contraction.
  Proc Natl Acad Sci U S A, 94, 9631-9636.  
9369475 T.Shimada, N.Sasaki, R.Ohkura, and K.Sutoh (1997).
Alanine scanning mutagenesis of the switch I region in the ATPase site of Dictyostelium discoideum myosin II.
  Biochemistry, 36, 14037-14043.  
9138552 W.H.Guilford, D.E.Dupuis, G.Kennedy, J.Wu, J.B.Patlak, and D.M.Warshaw (1997).
Smooth muscle and skeletal muscle myosins produce similar unitary forces and displacements in the laser trap.
  Biophys J, 72, 1006-1021.  
9171832 X.Z.Liu, J.Walsh, P.Mburu, J.Kendrick-Jones, M.J.Cope, K.P.Steel, and S.D.Brown (1997).
Mutations in the myosin VIIA gene cause non-syndromic recessive deafness.
  Nat Genet, 16, 188-190.  
9083688 Y.C.Sasaki, K.Yasuda, Y.Suzuki, T.Ishibashi, I.Satoh, Y.Fujiki, and S.Ishiwata (1997).
Two-dimensional arrangement of a functional protein by cysteine-gold interaction: enzyme activity and characterization of a protein monolayer on a gold substrate.
  Biophys J, 72, 1842-1848.  
9208928 Y.Hirayama, and S.Watabe (1997).
Structural differences in the crossbridge head of temperature-associated myosin subfragment-1 isoforms from carp fast skeletal muscle.
  Eur J Biochem, 246, 380-387.  
9138576 Y.Zhang, Z.Shao, A.P.Somlyo, and A.V.Somlyo (1997).
Cryo-atomic force microscopy of smooth muscle myosin.
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8637864 A.A.Bobkov, E.A.Bobkova, S.H.Lin, and E.Reisler (1996).
The role of surface loops (residues 204-216 and 627-646) in the motor function of the myosin head.
  Proc Natl Acad Sci U S A, 93, 2285-2289.  
8928223 A.F.Wright, and I.Jackson (1996).
Myosin diversity and disease.
  Trends Genet, 12, 206-209.  
8672723 A.G.Szent-Györgyi (1996).
Regulation of contraction by calcium binding myosins.
  Biophys Chem, 59, 357-363.  
8805510 A.Houdusse, and C.Cohen (1996).
Structure of the regulatory domain of scallop myosin at 2 A resolution: implications for regulation.
  Structure, 4, 21-32.
PDB code: 1wdc
8994973 A.Houdusse, M.Silver, and C.Cohen (1996).
A model of Ca(2+)-free calmodulin binding to unconventional myosins reveals how calmodulin acts as a regulatory switch.
  Structure, 4, 1475-1490.
PDB code: 1aji
8799143 A.Weisberg, and S.Winegrad (1996).
Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle.
  Proc Natl Acad Sci U S A, 93, 8999-9003.  
8785347 B.B.Adhikari, and P.G.Fajer (1996).
Myosin head orientation and mobility during isometric contraction: effects of osmotic compression.
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8913612 B.Brenner, S.Xu, J.M.Chalovich, and L.C.Yu (1996).
Radial equilibrium lengths of actomyosin cross-bridges in muscle.
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  8725228 B.Patterson, and J.A.Spudich (1996).
Cold-sensitive mutations of Dictyostelium myosin heavy chain highlight functional domains of the myosin motor.
  Genetics, 143, 801-810.  
8707847 C.A.Kelley, J.R.Sellers, D.L.Gard, D.Bui, R.S.Adelstein, and I.C.Baines (1996).
Xenopus nonmuscle myosin heavy chain isoforms have different subcellular localizations and enzymatic activities.
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8611530 C.A.Smith, and I.Rayment (1996).
X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution.
  Biochemistry, 35, 5404-5417.
PDB code: 1vom
8785318 C.A.Smith, and I.Rayment (1996).
Active site comparisons highlight structural similarities between myosin and other P-loop proteins.
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8816286 C.Aguado-Velasco, M.Véron, J.A.Rambow, and E.R.Kuczmarski (1996).
NDP kinase can modulate contraction of Dictyostelium cytoskeletons.
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8619986 C.J.Miller, T.C.Doyle, E.Bobkova, D.Botstein, and E.Reisler (1996).
Mutational analysis of the role of hydrophobic residues in the 338-348 helix on actin in actomyosin interactions.
  Biochemistry, 35, 3670-3676.  
8968602 C.L.Berger, J.S.Craik, D.R.Trentham, J.E.Corrie, and Y.E.Goldman (1996).
Fluorescence polarization of skeletal muscle fibers labeled with rhodamine isomers on the myosin heavy chain.
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8906622 C.L.Perreault-Micale, V.N.Kalabokis, L.Nyitray, and A.G.Szent-Györgyi (1996).
Sequence variations in the surface loop near the nucleotide binding site modulate the ATP turnover rates of molluscan myosins.
  J Muscle Res Cell Motil, 17, 543-553.  
8805521 C.W.Müller, G.J.Schlauderer, J.Reinstein, and G.E.Schulz (1996).
Adenylate kinase motions during catalysis: an energetic counterweight balancing substrate binding.
  Structure, 4, 147-156.
PDB code: 4ake
8807883 D.D.Hackney (1996).
Myosin and kinesin: mother and child reunited.
  Chem Biol, 3, 525-528.  
8555221 D.Gopal, and M.Burke (1996).
Myosin subfragment 1 hydrophobicity changes associated with different nucleotide-induced conformations.
  Biochemistry, 35, 506-512.  
8622919 D.Weil, G.Levy, I.Sahly, F.Levi-Acobas, S.Blanchard, A.El-Amraoui, F.Crozet, H.Philippe, M.Abitbol, and C.Petit (1996).
Human myosin VIIA responsible for the Usher 1B syndrome: a predicted membrane-associated motor protein expressed in developing sensory epithelia.
  Proc Natl Acad Sci U S A, 93, 3232-3237.  
8785300 E.Kim, C.J.Miller, M.Motoki, K.Seguro, A.Muhlrad, and E.Reisler (1996).
Myosin-induced changes in F-actin: fluorescence probing of subdomain 2 by dansyl ethylenediamine attached to Gln-41.
  Biophys J, 70, 1439-1446.  
8842197 F.G.Díaz Baños, J.Bordas, J.Lowy, and A.Svensson (1996).
Small segmental rearrangements in the myosin head can explain force generation in muscle.
  Biophys J, 71, 576-589.  
8769415 F.Kinose, S.X.Wang, U.S.Kidambi, C.L.Moncman, and D.A.Winkelmann (1996).
Glycine 699 is pivotal for the motor activity of skeletal muscle myosin.
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8994081 G.J.Rapp, and J.S.Davis (1996).
X-ray diffraction studies on thermally induced tension generation in rigor muscle.
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8804617 G.M.Diffee, J.R.Patel, F.C.Reinach, M.L.Greaser, and R.L.Moss (1996).
Altered kinetics of contraction in skeletal muscle fibers containing a mutant myosin regulatory light chain with reduced divalent cation binding.
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8783394 H.Nakamura (1996).
Roles of electrostatic interaction in proteins.
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8736548 I.Rayment (1996).
Kinesin and myosin: molecular motors with similar engines.
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8952512 J.C.Grammer, J.A.Loo, C.G.Edmonds, C.R.Cremo, and R.G.Yount (1996).
Chemistry and mechanism of vanadate-promoted photooxidative cleavage of myosin.
  Biochemistry, 35, 15582-15592.  
8784354 J.Gollub, C.R.Cremo, and R.Cooke (1996).
ADP release produces a rotation of the neck region of smooth myosin but not skeletal myosin.
  Nat Struct Biol, 3, 796-802.  
9172757 J.R.Patel, G.M.Diffee, and R.L.Moss (1996).
Myosin regulatory light chain modulates the Ca2+ dependence of the kinetics of tension development in skeletal muscle fibers.
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8740428 J.R.Sellers, H.V.Goodson, and F.Wang (1996).
A myosin family reunion.
  J Muscle Res Cell Motil, 17, 7.  
8793719 J.R.Sellers (1996).
Kinesin and NCD, two structural cousins of myosin.
  J Muscle Res Cell Motil, 17, 173-175.  
8994878 K.C.Holmes (1996).
Muscle proteins--their actions and interactions.
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8970737 K.M.Ruppel, and J.A.Spudich (1996).
Structure-function analysis of the motor domain of myosin.
  Annu Rev Cell Dev Biol, 12, 543-573.  
  8862525 K.M.Ruppel, and J.A.Spudich (1996).
Structure-function studies of the myosin motor domain: importance of the 50-kDa cleft.
  Mol Biol Cell, 7, 1123-1136.  
8673105 K.Poetter, H.Jiang, S.Hassanzadeh, S.R.Master, A.Chang, M.C.Dalakas, I.Rayment, J.R.Sellers, L.Fananapazir, and N.D.Epstein (1996).
Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle.
  Nat Genet, 13, 63-69.  
8970724 K.R.Ayscough, and D.G.Drubin (1996).
ACTIN: general principles from studies in yeast.
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8756480 L.Zhao, J.Gollub, and R.Cooke (1996).
Orientation of paramagnetic probes attached to gizzard regulatory light chain bound to myosin heads in rabbit skeletal muscle.
  Biochemistry, 35, 10158-10165.  
  8947029 M.Anson, M.A.Geeves, S.E.Kurzawa, and D.J.Manstein (1996).
Myosin motors with artificial lever arms.
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8646534 M.B.Swindells, and M.Ikura (1996).
Pre-formation of the semi-open conformation by the apo-calmodulin C-terminal domain and implications binding IQ-motifs.
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8884597 M.D.Peterson, A.S.Urioste, and M.A.Titus (1996).
Dictyostelium discoideum myoJ: a member of a broadly defined myosin V class or a class XI unconventional myosin?
  J Muscle Res Cell Motil, 17, 411-424.  
  8900236 M.D.Weston, P.M.Kelley, L.D.Overbeck, M.Wagenaar, D.J.Orten, T.Hasson, Z.Y.Chen, D.Corey, M.Mooseker, J.Sumegi, C.Cremers, C.Moller, S.G.Jacobson, M.B.Gorin, and W.J.Kimberling (1996).
Myosin VIIA mutation screening in 189 Usher syndrome type 1 patients.
  Am J Hum Genet, 59, 1074-1083.  
8848832 M.Ikura (1996).
Calcium binding and conformational response in EF-hand proteins.
  Trends Biochem Sci, 21, 14-17.  
8805581 M.J.Cope, J.Whisstock, I.Rayment, and J.Kendrick-Jones (1996).
Conservation within the myosin motor domain: implications for structure and function.
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8804587 M.Kekic, W.Huang, P.D.Moens, B.D.Hambly, and C.G.dos Remedios (1996).
Distance measurements near the myosin head-rod junction using fluorescence spectroscopy.
  Biophys J, 71, 40-47.  
8692854 M.Mazumdar, A.Mikami, M.A.Gee, and R.B.Vallee (1996).
In vitro motility from recombinant dynein heavy chain.
  Proc Natl Acad Sci U S A, 93, 6552-6556.