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PDBsum entry 2mvp
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protein ligands Protein-protein interface(s) links
Hydrolase(aspartic proteinase) PDB id
2mvp

 

 

 

 

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Contents
Protein chains
124 a.a.
Ligands
THR-PHE-GLN-ALA-
TYR-PRO-LEU-ARG-
GLU-ALA
Theoretical model
PDB id:
2mvp
Name: Hydrolase(aspartic proteinase)
Structure: Myeloblastosis associated viral protease complex with substrate thr- Phe- Gln- Ala- Tyr- Pro- Leu- Arg- Glu- Ala (theoretical model)
Source: Myeloblastosis associated virus
Authors: D.H.Ohlendorf,S.I.Foundling,F.R.Salemme
Key ref: D.H.Ohlendorf et al. (1992). Structural studies of the retroviral proteinase from avian myeloblastosis associated virus. Proteins, 14, 382-391. PubMed id: 1332025
Date:
07-Sep-90     Release date:   15-Jan-92    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P26315  (GAG_AVIMA) -  Proteinase p15
Seq:
Struc: 		124 a.a.
124 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: E.C.3.4.23.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
Proteins 14:382-391 (1992)
PubMed id: 1332025  
 
 
Structural studies of the retroviral proteinase from avian myeloblastosis associated virus.
D.H.Ohlendorf, S.I.Foundling, J.J.Wendoloski, J.Sedlacek, P.Strop, F.R.Salemme.
 
  ABSTRACT  
 
The structure of the retroviral proteinase from avian myeloblastosis associated virus (MAV) has been determined and refined at 2.2 A resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase-inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
  7474139 J.Konvalinka, M.A.Litterst, R.Welker, H.Kottler, F.Rippmann, A.M.Heuser, and H.G.Kräusslich (1995).
An active-site mutation in the human immunodeficiency virus type 1 proteinase (PR) causes reduced PR activity and loss of PR-mediated cytotoxicity without apparent effect on virus maturation and infectivity.
  J Virol, 69, 7180-7186.  
7493942 L.Menéndez-Arias, I.T.Weber, and S.Oroszlan (1995).
Mutational analysis of the substrate binding pocket of murine leukemia virus protease and comparison with human immunodeficiency virus proteases.
  J Biol Chem, 270, 29162-29168.  
8035212 S.D.Rufino, and T.L.Blundell (1994).
Structure-based identification and clustering of protein families and superfamilies.
  J Comput Aided Mol Des, 8, 5.  
  8302216 W.G.Dougherty, and B.L.Semler (1993).
Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.
  Microbiol Rev, 57, 781-822.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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