spacer
spacer

PDBsum entry 2lgc

Go to PDB code: 
protein links
Transferase PDB id
2lgc
Jmol
Contents
Protein chain
359 a.a.
PDB id:
2lgc
Name: Transferase
Title: Joint nmr and x-ray refinement reveals the structure of a no dibenzo[a,d]cycloheptenone inhibitor/p38 map kinase complex solution
Structure: Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, cytokine suppressive anti- inflammatory drug-binding protein, csaid-binding protein, c kinase mxi2, max-interacting protein 2, mitogen-activated p kinase p38 alpha, map kinase p38 alpha, sapk2a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.
NMR struc: 10 models
Authors: M.Habeck
Key ref: V.S.Honndorf et al. (2012). Inferential NMR/X-ray-based structure determination of a dibenzo[a,d]cycloheptenone inhibitor-p38α MAP kinase complex in solution. Angew Chem Int Ed Engl, 51, 2359-2362. PubMed id: 22275118
Date:
25-Jul-11     Release date:   25-Jul-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14
Seq:
Struc:
360 a.a.
359 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   8 terms 
  Biological process     intracellular signal transduction   71 terms 
  Biochemical function     nucleotide binding     11 terms  

 

 
    reference    
 
 
Angew Chem Int Ed Engl 51:2359-2362 (2012)
PubMed id: 22275118  
 
 
Inferential NMR/X-ray-based structure determination of a dibenzo[a,d]cycloheptenone inhibitor-p38α MAP kinase complex in solution.
V.S.Honndorf, N.Coudevylle, S.Laufer, S.Becker, C.Griesinger, M.Habeck.
 
  ABSTRACT  
 
No abstract given.