PDBsum entry 2l2k

Hydrolase/RNA

PDB id

2l2k

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Contents

			Protein chain

					71 a.a. *

			DNA/RNA

* Residue conservation analysis

PDB id:

2l2k

Links
- PDBe
- RCSB
- MMDB
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- Proteopedia
- CATH
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Name:

Hydrolase/RNA

Title:

Solution nmr structure of the r/g stem loop RNA-adar2 dsrbm2 complex

Structure:

Adenosine deaminase. Chain: b. Fragment: unp residues 231-301. Synonym: RNA-specific, b1, isoform cra_d. Engineered: yes. RNA (42-mer). Chain: a. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: adar2, adarb1, mcg_3378, red1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Homo sapiens. Human.

NMR struc:

20 models

Authors:

F.H.-T.Allain,F.C.Oberstrass,R.Stefl

Key ref:

R.Stefl et al. (2010). The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove. Cell, 143, 225-237. PubMed id: 20946981

Date:

20-Aug-10

Release date:

27-Oct-10

PROCHECK

	Headers

	References

Protein chain

Q91ZS8 (RED1_MOUSE) - Double-stranded RNA-specific editase 1 from Mus musculus

Seq: Struc:

Seq: Struc:					711 a.a. 71 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

DNA/RNA chain

G-G-U-A-A-G-G-U-G-G-G-U-G-G-A-A-U-C-C-U-U-C-G-G-G-A-U-C-C-C-A-C-C-U-A-C-C-C-U- 42 bases



		Enzyme reactions

Enzyme class:

E.C.3.5.4.37 - double-stranded Rna adenine deaminase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

adenosine in double-stranded RNA + H2O + H⁺ = inosine in double- stranded RNA + NH4⁺

	Cell 143:225-237 (2010)
PubMed id: 20946981

The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove.
R.Stefl, F.C.Oberstrass, J.L.Hood, M.Jourdan, M.Zimmermann, L.Skrisovska, C.Maris, L.Peng, C.Hofr, R.B.Emeson, F.H.Allain.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23001123

G.I.Rice, P.R.Kasher, G.M.Forte, N.M.Mannion, S.M.Greenwood, M.Szynkiewicz, J.E.Dickerson, S.S.Bhaskar, M.Zampini, T.A.Briggs, E.M.Jenkinson, C.A.Bacino, R.Battini, E.Bertini, P.A.Brogan, L.A.Brueton, M.Carpanelli, C.De Laet, P.de Lonlay, M.Del Toro, I.Desguerre, E.Fazzi, A.Garcia-Cazorla, A.Heiberg, M.Kawaguchi, R.Kumar, J.P.Lin, C.M.Lourenco, A.M.Male, W.Marques, C.Mignot, I.Olivieri, S.Orcesi, P.Prabhakar, M.Rasmussen, R.A.Robinson, F.Rozenberg, J.L.Schmidt, K.Steindl, T.Y.Tan, W.G.van der Merwe, A.Vanderver, G.Vassallo, E.L.Wakeling, E.Wassmer, E.Whittaker, J.H.Livingston, P.Lebon, T.Suzuki, P.J.McLaughlin, L.P.Keegan, M.A.O'Connell, S.C.Lovell, and Y.J.Crow (2012).
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature.

Nat Genet, 44, 1243-1248.

21145228

S.R.Nallagatla, R.Toroney, and P.C.Bevilacqua (2011).
Regulation of innate immunity through RNA structure and the protein kinase PKR.

Curr Opin Struct Biol, 21, 119-127.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.