spacer
spacer

PDBsum entry 2l0x

Go to PDB code: 
protein ligands metals links
Hydrolase PDB id
2l0x
Jmol
Contents
Protein chain
169 a.a. *
Ligands
GDP
Metals
_MG
* Residue conservation analysis
PDB id:
2l0x
Name: Hydrolase
Title: Solution structure of the 21 kda gtpase rheb bound to gdp
Structure: Gtp-binding protein rheb. Chain: a. Synonym: ras homolog enriched in brain. Engineered: yes
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: rheb. Expressed in: escherichia coli. Expression_system_taxid: 469008.
NMR struc: 20 models
Authors: R.Stoll,R.Heumann,C.Berghaus,G.Kock
Key ref: S.Karassek et al. (2010). Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J Biol Chem, 285, 33979-33991. PubMed id: 20685651
Date:
19-Jul-10     Release date:   04-Aug-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q62639  (RHEB_RAT) -  GTP-binding protein Rheb
Seq:
Struc:
184 a.a.
169 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     intracellular   7 terms 
  Biological process     signal transduction   6 terms 
  Biochemical function     nucleotide binding     7 terms  

 

 
J Biol Chem 285:33979-33991 (2010)
PubMed id: 20685651  
 
 
Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.
S.Karassek, C.Berghaus, M.Schwarten, C.G.Goemans, N.Ohse, G.Kock, K.Jockers, S.Neumann, S.Gottfried, C.Herrmann, R.Heumann, R.Stoll.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21412983 N.A.Neuman, and E.P.Henske (2011).
Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.
  EMBO Mol Med, 3, 189-200.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.