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PDBsum entry 2k3t
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Structural protein
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PDB id
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2k3t
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Contents |
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* Residue conservation analysis
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PDB id:
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Structural protein
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Title:
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Solution structure of ig-like domain 23 from human filamin a
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Structure:
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Filamin-a. Chain: a. Fragment: ig-like domain 23 of filamin a (unp residues 2427-2522). Synonym: alpha-filamin, filamin-1, endothelial actin-binding protein, actin-binding protein 280, abp-280, non-muscle filamin. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: flna, fln, fln1. Expressed in: escherichia coli
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NMR struc:
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20 models
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Authors:
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O.K.Heikkinen,J.Ylanne,I.Kilpelainen,O.Kupiainen
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Key ref:
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F.Nakamura
et al.
(2009).
Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.
Plos One,
4,
e4928.
PubMed id:
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Date:
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16-May-08
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Release date:
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31-Mar-09
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PROCHECK
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Headers
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References
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P21333
(FLNA_HUMAN) -
Filamin-A from Homo sapiens
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Seq:
Struc:
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2647 a.a.
99 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Plos One
4:e4928
(2009)
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PubMed id:
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Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.
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F.Nakamura,
O.Heikkinen,
O.T.Pentikäinen,
T.M.Osborn,
K.E.Kasza,
D.A.Weitz,
O.Kupiainen,
P.Permi,
I.Kilpeläinen,
J.Ylänne,
J.H.Hartwig,
T.P.Stossel.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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B.A.Kesner,
S.L.Milgram,
B.R.Temple,
and
N.V.Dokholyan
(2010).
Isoform divergence of the filamin family of proteins.
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Mol Biol Evol,
27,
283-295.
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B.Nieves,
C.W.Jones,
R.Ward,
Y.Ohta,
C.G.Reverte,
and
S.E.LaFlamme
(2010).
The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling.
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J Cell Sci,
123,
1216-1226.
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H.H.Santos,
P.P.Garcia,
L.Pereira,
L.L.Leão,
R.A.Aguiar,
A.M.Lana,
M.R.Carvalho,
and
M.J.Aguiar
(2010).
Mutational analysis of two boys with the severe perinatally lethal Melnick-Needles syndrome.
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Am J Med Genet A,
152,
726-731.
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M.MacPherson,
and
S.C.Fagerholm
(2010).
Filamin and filamin-binding proteins in integrin-regulation and adhesion. Focus on: "FilaminA is required for vimentin-mediated cell adhesion and spreading".
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Am J Physiol Cell Physiol,
298,
C206-C208.
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O.K.Heikkinen,
S.Ruskamo,
P.V.Konarev,
D.I.Svergun,
T.Iivanainen,
S.M.Heikkinen,
P.Permi,
H.Koskela,
I.Kilpeläinen,
and
J.Ylänne
(2009).
Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin.
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J Biol Chem,
284,
25450-25458.
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PDB codes:
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S.S.Ithychanda,
D.Hsu,
H.Li,
L.Yan,
D.D.Liu,
D.Liu,
M.Das,
E.F.Plow,
and
J.Qin
(2009).
Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk.
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J Biol Chem,
284,
35113-35121.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
