PDBsum entry: 2jxz

Hormone

PDB id: 2jxz

Contents

Protein chain

33 a.a. *

* Residue conservation analysis

PDB id:

2jxz

Name:

Hormone

Title:

Solution conformation of a non-amyloidogenic analogue of hum calcitonin in sodium dodecyl sulfate micelles

Structure:

Calcitonin. Chain: a. Fragment: calcitonin, unp residues 85-116. Engineered: yes. Mutation: yes

Source:

Synthetic: yes. Other_details: peptide synthesis

NMR struc:

20 models

Authors:

G.Andreotti,R.Vitale,C.Avidan-Shpalter,P.Amodeo,E.Gazit,A.Mo

Key ref:

G.Andreotti et al. (2011). Converting the highly amyloidogenic human calcitonin into a powerful fibril inhibitor by three-dimensional structure homology with a non-amyloidogenic analogue. J Biol Chem, 286, 2707-2718. PubMed id: 21078667 DOI: 10.1074/jbc.M110.182014

Date:

03-Dec-07 Release date: 25-Nov-08

Protein chain

P01258  (CALC_HUMAN) -  Calcitonin

Seq: 141 a.a.

Struc: 33 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 

• Cellular component: extracellular region (1 term)
• Biochemical function: hormone activity (1 term)

DOI no: 10.1074/jbc.M110.182014

J Biol Chem 286:2707-2718 (2011)

PubMed id: 21078667

Converting the highly amyloidogenic human calcitonin into a powerful fibril inhibitor by three-dimensional structure homology with a non-amyloidogenic analogue.

G.Andreotti, R.M.Vitale, C.Avidan-Shpalter, P.Amodeo, E.Gazit, A.Motta.

ABSTRACT

No abstract given.