PDBsum entry 2ja0

Transferase

PDB id: 2ja0

Contents

Protein chain

287 a.a.

Ligands

SCN ×2

EDO ×5

HQP

Waters ×148

Obsolete entry

PDB id:

2ja0

Name:

Transferase

Title:

Crystal structure of human ste20-like kinase bound to 4-(4- (5-cyclopropyl-1h-pyrazol-3-ylamino)-quinazolin-2-ylamino)- benzonitrile

Structure:

Ste20-like serine/threonine-protein kinase. Chain: a. Fragment: kinase domain, residues 19-320. Synonym: ste20-like serine-threonine kinase. Ste20-like kinase, ste20-related serine/threonine-protein kinase, ste20-related kinase, hslk, serine/threonine-protein kinase 2, ctcl tumor antigen se20-9. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Expressed in: escherichia coli.

Resolution:

2.30Å R-factor: 0.200 R-free: 0.235

Authors:

A.C.W.Pike,P.Rellos,O.Fedorov,T.Keates,E.Salah,P.Savitsky, E.Papagrigoriou,G.Bunkoczi,J.E.Debreczeni,F.Von Delft, C.H.Arrowsmith,A.Edwards,J.Weigelt,M.Sundstrom,S.Knapp

Key ref:

A.C.W.Pike et al. Crystal structure of human ste20-Like kinase bound to 4-(4-(5-Cyclopropyl-1h-Pyrazol-3-Ylamino)- Quinazolin-2-Ylamino)-Benzonitrile. To be published, .

Date:

16-Nov-06 Release date: 16-Jan-07

Protein chain

Q9H2G2  (SLK_HUMAN) -  STE20-like serine/threonine-protein kinase from Homo sapiens

Seq: 1235 a.a.

Struc: 287 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site