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PDBsum entry 2j6l

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protein ligands metals Protein-protein interface(s) links
Oxidoreductase PDB id
2j6l
Jmol
Contents
Protein chain
(+ 2 more) 497 a.a. *
Ligands
NAI ×8
Metals
_NA ×8
_BR ×15
Waters ×5031
* Residue conservation analysis
PDB id:
2j6l
Name: Oxidoreductase
Title: Structure of aminoadipate-semialdehyde dehydrogenase
Structure: Aldehyde dehydrogenase family 7 member a1. Chain: a, b, c, d, e, f, g, h. Synonym: antiquitin-1, aminoadipate-semialdehyde dehydrogenase. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_cell_line: de3-r3.
Biol. unit: Tetramer (from PDB file)
Resolution:
1.30Å     R-factor:   0.140     R-free:   0.189
Authors: G.Bunkoczi,K.Guo,J.E.Debreczeni,C.Smee,C.Arrowsmith, A.Edwards,M.Sundstrom,J.Weigelt,F.Von Delft,U.Oppermann
Key ref: G.Bunkoczi et al. Structure of aminoadipate-Semialdehyde dehydrogenase. To be published, .
Date:
29-Sep-06     Release date:   12-Oct-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P49419  (AL7A1_HUMAN) -  Alpha-aminoadipic semialdehyde dehydrogenase
Seq:
Struc:
 
Seq:
Struc:
539 a.a.
497 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class 2: E.C.1.2.1.3  - Aldehyde dehydrogenase (NAD(+)).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: An aldehyde + NAD+ + H2O = a carboxylate + NADH
aldehyde
+
NAD(+)
Bound ligand (Het Group name = NAI)
corresponds exactly
+ H(2)O
= carboxylate
+ NADH
   Enzyme class 3: E.C.1.2.1.31  - L-aminoadipate-semialdehyde dehydrogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
      Reaction: (S)-2-amino-6-oxohexanoate + NAD(P)(+) + H2O = L-2-aminoadipate + NAD(P)H
(S)-2-amino-6-oxohexanoate
+
NAD(P)(+)
Bound ligand (Het Group name = NAI)
matches with 91.00% similarity
+ H(2)O
= L-2-aminoadipate
+ NAD(P)H
   Enzyme class 4: E.C.1.2.1.8  - Betaine-aldehyde dehydrogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Betaine aldehyde + NAD+ + H2O = betaine + NADH
Betaine aldehyde
+
NAD(+)
Bound ligand (Het Group name = NAI)
corresponds exactly
+ H(2)O
= betaine
+ NADH
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   6 terms 
  Biological process     metabolic process   8 terms 
  Biochemical function     protein binding     6 terms