PDBsum entry 2j4a

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protein ligands links
Receptor PDB id
Protein chain
251 a.a. *
Waters ×107
* Residue conservation analysis
PDB id:
Name: Receptor
Title: Human thyroid hormone receptor beta ligand binding domain in complex with kb131084
Structure: Thyroid hormone receptor beta-1. Chain: a. Fragment: ligand binding domain, residues 209-461. Synonym: thyroid hormone receptor beta lbd. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
2.20Å     R-factor:   0.229     R-free:   0.272
Authors: M.Farnegardh
Key ref: K.Koehler et al. (2006). Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem, 49, 6635-6637. PubMed id: 17154490 DOI: 10.1021/jm060521i
28-Aug-06     Release date:   25-Sep-07    
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Protein chain
Pfam   ArchSchema ?
P10828  (THB_HUMAN) -  Thyroid hormone receptor beta
461 a.a.
251 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     steroid hormone mediated signaling pathway   2 terms 
  Biochemical function     DNA binding     4 terms  


DOI no: 10.1021/jm060521i J Med Chem 49:6635-6637 (2006)
PubMed id: 17154490  
Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor.
K.Koehler, S.Gordon, P.Brandt, B.Carlsson, A.Bäcksbro-Saeidi, T.Apelqvist, P.Agback, G.J.Grover, W.Nelson, M.Grynfarb, M.Färnegårdh, S.Rehnmark, J.Malm.
A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.

Literature references that cite this PDB file's key reference

  PubMed id Reference
19111515 M.Jeyakumar, and J.A.Katzenellenbogen (2009).
A dual-acceptor time-resolved Föster resonance energy transfer assay for simultaneous determination of thyroid hormone regulation of corepressor and coactivator binding to the thyroid hormone receptor: Mimicking the cellular context of thyroid hormone action.
  Anal Biochem, 386, 73-78.  
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