PDBsum entry: 2iwj

Transferase

PDB id: 2iwj

Contents

Protein chain

27 a.a.

Metals

_ZN

PDB id:

2iwj

Name:

Transferase

Title:

Solution structure of the zn complex of HIV-2 ncp(23-49) peptide, encompassing protein cchc-linker, distal cchc zn- binding motif and c-terminal tail.

Structure:

Gag-pol polyprotein. Chain: a. Fragment: residues 405-431 of ncp. Synonym: nucleocapsid protein, pr160gag-pol. Other_details: fragment 23-49 of ncp corresponds to 405- 431 of the whole HIV-2 gag protein contains one zn ion in a cchc zn-binding domains

Source:

Synthetic: yes. Human immunodeficiency virus type 2. HIV-2. Organism_taxid: 11709. Variant: isolate ghana-1 subtype a

NMR struc:

30 models

Authors:

P.Amodeo,M.A.Castiglione Morelli,A.Ostuni,P.Cristinziano, A.Bavoso

Key ref:

P.Amodeo et al. Structural features of the c-Terminal zinc finger domain of the HIV-2 nc protein (residues 23-49).. To be published,

Date:

30-Jun-06 Release date: 09-Oct-07

Protein chain

P18042  (POL_HV2G1) -  Gag-Pol polyprotein

Seq: 1464 a.a.

Struc: 27 a.a.

Enzyme reactions

• Enzyme class 1: E.C.2.7.7.49 - RNA-directed Dna polymerase.
• Reaction: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
• Enzyme class 2: E.C.2.7.7.7 - DNA-directed Dna polymerase.
• Reaction: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
• Enzyme class 3: E.C.3.1.13.2 - Exoribonuclease H.
• Reaction: Exonucleolytic cleavage to 5'-phosphomonoester oligonucleotides in both 5'- to 3'- and 3'- to 5'-directions.
• Enzyme class 4: E.C.3.1.26.13 - Retroviral ribonuclease H.
• Enzyme class 5: E.C.3.4.23.47 - HIV-2 retropepsin.

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Biochemical function: nucleic acid binding (2 terms)