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PDBsum entry 2isi
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Residue conservation analysis
Crystal structure of ape1 from homo sapiens in a new crystal form complexed with a ligand
DNA-(apurinic or apyrimidinic site) lyase. Chain: a, b, c. Synonym: ap endonuclease 1, apex nuclease, apen, ref-1 protein. Engineered: yes
Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
R.Agarwal and m.d.naidu Crystal structure of hape1 in a new crystal form with a bound ligand: implications on catalytic mechanism and its inhibition.
To be published
(APEX1_HUMAN) - DNA-(apurinic or apyrimidinic site) lyase
- DNA-(apurinic or apyrimidinic site) lyase.
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Gene Ontology (GO) functional annotation
cellular response to cAMP
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