PDBsum entry 2isd

Go to PDB code: 
protein ligands Protein-protein interface(s) links
Lipid degradation PDB id
Protein chains
513 a.a. *
561 a.a. *
ACT ×2
Waters ×673
* Residue conservation analysis
PDB id:
Name: Lipid degradation
Title: Phosphoinositide-specific phospholipasE C-delta1 from rat
Structure: Phosphoinositide-specific phospholipasE C, isozyme delta1. Chain: a, b. Synonym: plc-d1. Engineered: yes. Mutation: yes. Other_details: catalytically-active deletion variant that lacks an n-terminal ph domain
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: cdna fragment. Expressed in: escherichia coli. Expression_system_taxid: 562.
2.50Å     R-factor:   0.227     R-free:   0.280
Authors: L.-O.Essen,O.Perisic,R.L.Williams
Key ref: L.O.Essen et al. (1996). Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta. Nature, 380, 595-602. PubMed id: 8602259
31-Mar-97     Release date:   07-Jul-97    
Supersedes: 1isd
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
P10688  (PLCD1_RAT) -  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
756 a.a.
513 a.a.
Protein chain
Pfam   ArchSchema ?
P10688  (PLCD1_RAT) -  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
756 a.a.
561 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.  - Phosphoinositide phospholipase C.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

myo-Inositol Phosphate Metabolism
      Reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
+ H(2)O
= 1D-myo-inositol 1,4,5-trisphosphate
+ diacylglycerol
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     intracellular signal transduction   3 terms 
  Biochemical function     calcium ion binding     3 terms  


Nature 380:595-602 (1996)
PubMed id: 8602259  
Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.
L.O.Essen, O.Perisic, R.Cheung, M.Katan, R.L.Williams.
Mammalian phosphoinositide-specific phospholipase C enzymes (PI-PLC) act as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. The 2.4-A structure of phospholipase C delta 1 reveals a multidomain protein incorporating modules shared by many signalling proteins. The structure suggests a mechanism for membrane attachment and Ca2+-dependent hydrolysis of second-messenger precursors. The regulation and reversible membrane association of PI-PLC may serve as a model for understanding other multidomain enzymes involved in phospholipid signalling.

Literature references that cite this PDB file's key reference

  PubMed id Reference
20870410 T.D.Bunney, and M.Katan (2011).
PLC regulation: emerging pictures for molecular mechanisms.
  Trends Biochem Sci, 36, 88-96.  
20023071 H.Moreno, A.S.Linford, C.A.Gilchrist, and W.A.Petri (2010).
Phospholipid-binding protein EhC2A mediates calcium-dependent translocation of transcription factor URE3-BP to the plasma membrane of Entamoeba histolytica.
  Eukaryot Cell, 9, 695-704.  
19584136 E.Heytens, J.Parrington, K.Coward, C.Young, S.Lambrecht, S.Y.Yoon, R.A.Fissore, R.Hamer, C.M.Deane, M.Ruas, P.Grasa, R.Soleimani, C.A.Cuvelier, J.Gerris, M.Dhont, D.Deforce, L.Leybaert, and P.De Sutter (2009).
Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.
  Hum Reprod, 24, 2417-2428.  
19400837 H.S.Rho, J.Jeon, and Y.H.Lee (2009).
Phospholipase C-mediated calcium signalling is required for fungal development and pathogenicity in Magnaporthe oryzae.
  Mol Plant Pathol, 10, 337-346.  
19531496 K.L.Everett, T.D.Bunney, Y.Yoon, F.Rodrigues-Lima, R.Harris, P.C.Driscoll, K.Abe, H.Fuchs, Angelis, P.Yu, W.Cho, and M.Katan (2009).
Characterization of phospholipase C gamma enzymes with gain-of-function mutations.
  J Biol Chem, 284, 23083-23093.  
  19704699 K.Nakamura, and H.Sano (2009).
A plasma-membrane linker for the phosphoinositide-specific phospholipase C in tobacco plants.
  Plant Signal Behav, 4, 26-29.  
  19669422 M.De Pittà, M.Goldberg, V.Volman, H.Berry, and E.Ben-Jacob (2009).
Glutamate regulation of calcium and IP(3) oscillating and pulsating dynamics in astrocytes.
  J Biol Phys, 35, 383-411.  
19681039 M.Fujii, K.S.Yi, M.J.Kim, S.H.Ha, S.H.Ryu, P.G.Suh, and H.Yagisawa (2009).
Phosphorylation of phospholipase C-delta 1 regulates its enzymatic activity.
  J Cell Biochem, 108, 638-650.  
19004828 N.A.Ramakrishnan, M.J.Drescher, and D.G.Drescher (2009).
Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3.
  J Biol Chem, 284, 1364-1372.  
  19033212 T.K.Harden, S.N.Hicks, and J.Sondek (2009).
Phospholipase C isozymes as effectors of Ras superfamily GTPases.
  J Lipid Res, 50, S243-S248.  
18488142 A.V.Smrcka (2008).
G protein betagamma subunits: central mediators of G protein-coupled receptor signaling.
  Cell Mol Life Sci, 65, 2191-2214.  
18280495 E.Johnson, L.Bruschweiler-Li, S.A.Showalter, G.W.Vuister, F.Zhang, and R.Brüschweiler (2008).
Structure and dynamics of Ca2+-binding domain 1 of the Na+/Ca2+ exchanger in the presence and in the absence of Ca2+.
  J Mol Biol, 377, 945-955.  
18691970 S.N.Hicks, M.R.Jezyk, S.Gershburg, J.P.Seifert, T.K.Harden, and J.Sondek (2008).
General and versatile autoinhibition of PLC isozymes.
  Mol Cell, 31, 383-394.
PDB code: 2zkm
18184564 T.Wang, X.Wang, Q.Xie, and C.Montell (2008).
The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C.
  Neuron, 57, 56-68.  
17213187 C.Shao, X.Shi, H.Wehbi, C.Zambonelli, J.F.Head, B.A.Seaton, and M.F.Roberts (2007).
Dimer structure of an interfacially impaired phosphatidylinositol-specific phospholipase C.
  J Biol Chem, 282, 9228-9235.
PDB code: 2or2
17524618 G.Drin, and S.Scarlata (2007).
Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding--how many ways can you activate an enzyme?
  Cell Signal, 19, 1383-1392.  
17510957 J.L.Jiménez, and B.Davletov (2007).
Beta-strand recombination in tricalbin evolution and the origin of synaptotagmin-like C2 domains.
  Proteins, 68, 770-778.  
17430887 M.Nomikos, A.Mulgrew-Nesbitt, P.Pallavi, G.Mihalyne, I.Zaitseva, K.Swann, F.A.Lai, D.Murray, and S.McLaughlin (2007).
Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues.
  J Biol Chem, 282, 16644-16653.  
17222180 N.Uekama, T.Sugita, M.Okada, H.Yagisawa, and S.Tuzi (2007).
Phosphatidylserine induces functional and structural alterations of the membrane-associated pleckstrin homology domain of phospholipase C-delta1.
  FEBS J, 274, 177-187.  
17360437 S.W.Min, W.P.Chang, and T.C.Südhof (2007).
E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.
  Proc Natl Acad Sci U S A, 104, 3823-3828.  
16774926 D.A.Nicoll, M.R.Sawaya, S.Kwon, D.Cascio, K.D.Philipson, and J.Abramson (2006).
The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif.
  J Biol Chem, 281, 21577-21581.
PDB code: 2dpk
16669615 G.Drin, D.Douguet, and S.Scarlata (2006).
The pleckstrin homology domain of phospholipase Cbeta transmits enzymatic activation through modulation of the membrane-domain orientation.
  Biochemistry, 45, 5712-5724.  
16240320 H.Yagisawa (2006).
Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+.
  J Cell Biochem, 97, 233-243.  
16854985 K.Kuroda, M.Ito, T.Shikano, T.Awaji, A.Yoda, H.Takeuchi, K.Kinoshita, and S.Miyazaki (2006).
The role of X/Y linker region and N-terminal EF-hand domain in nuclear translocation and Ca2+ oscillation-inducing activities of phospholipase Czeta, a mammalian egg-activating factor.
  J Biol Chem, 281, 27794-27805.  
16754659 L.Dowal, P.Provitera, and S.Scarlata (2006).
Stable association between G alpha(q) and phospholipase C beta 1 in living cells.
  J Biol Chem, 281, 23999-24014.  
16410353 M.J.Begley, G.S.Taylor, M.A.Brock, P.Ghosh, V.L.Woods, and J.E.Dixon (2006).
Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.
  Proc Natl Acad Sci U S A, 103, 927-932.
PDB codes: 1zsq 1zvr
17115053 M.R.Jezyk, J.T.Snyder, S.Gershberg, D.K.Worthylake, T.K.Harden, and J.Sondek (2006).
Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
  Nat Struct Mol Biol, 13, 1135-1140.
PDB code: 2fju
16799264 S.Miyazaki, and M.Ito (2006).
Calcium signals for egg activation in mammals.
  J Pharmacol Sci, 100, 545-552.  
16402909 T.K.Harden, and J.Sondek (2006).
Regulation of phospholipase C isozymes by ras superfamily GTPases.
  Annu Rev Pharmacol Toxicol, 46, 355-379.  
15843967 J.Liu, N.Jambunathan, and T.W.McNellis (2005).
Transgenic expression of the von Willebrand A domain of the BONZAI 1/COPINE 1 protein triggers a lesion-mimic phenotype in Arabidopsis.
  Planta, 221, 85-94.  
15468068 K.Harada, H.Takeuchi, M.Oike, M.Matsuda, T.Kanematsu, H.Yagisawa, K.I.Nakayama, K.Maeda, C.Erneux, and M.Hirata (2005).
Role of PRIP-1, a novel Ins(1,4,5)P3 binding protein, in Ins(1,4,5)P3-mediated Ca2+ signaling.
  J Cell Physiol, 202, 422-433.  
  16129772 L.F.Horowitz, W.Hirdes, B.C.Suh, D.W.Hilgemann, K.Mackie, and B.Hille (2005).
Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current.
  J Gen Physiol, 126, 243-262.  
16000311 M.Nomikos, L.M.Blayney, M.G.Larman, K.Campbell, A.Rossbach, C.M.Saunders, K.Swann, and F.A.Lai (2005).
Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations.
  J Biol Chem, 280, 31011-31018.  
15743817 M.Tadano, H.Edamatsu, S.Minamisawa, U.Yokoyama, Y.Ishikawa, N.Suzuki, H.Saito, D.Wu, M.Masago-Toda, Y.Yamawaki-Kataoka, T.Setsu, T.Terashima, S.Maeda, T.Satoh, and T.Kataoka (2005).
Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon.
  Mol Cell Biol, 25, 2191-2199.  
15845450 P.Yu, R.Constien, N.Dear, M.Katan, P.Hanke, T.D.Bunney, S.Kunder, L.Quintanilla-Martinez, U.Huffstadt, A.Schröder, N.P.Jones, T.Peters, H.Fuchs, Angelis, M.Nehls, J.Grosse, P.Wabnitz, T.P.Meyer, K.Yasuda, M.Schiemann, C.Schneider-Fresenius, W.Jagla, A.Russ, A.Popp, M.Josephs, A.Marquardt, J.Laufs, C.Schmittwolf, H.Wagner, K.Pfeffer, and G.C.Mudde (2005).
Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.
  Immunity, 22, 451-465.  
15817490 R.S.Sidhu, R.R.Clough, and R.P.Bhullar (2005).
Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin.
  J Biol Chem, 280, 21933-21941.  
15611108 T.M.Bonacci, M.Ghosh, S.Malik, and A.V.Smrcka (2005).
Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2.
  J Biol Chem, 280, 10174-10181.  
15790568 Z.Kouchi, T.Shikano, Y.Nakamura, H.Shirakawa, K.Fukami, and S.Miyazaki (2005).
The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta.
  J Biol Chem, 280, 21015-21021.  
14766750 A.C.Wild, J.W.Yu, M.A.Lemmon, and K.J.Blumer (2004).
The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate.
  J Biol Chem, 279, 17101-17110.  
14623879 J.H.Evans, and C.C.Leslie (2004).
The cytosolic phospholipase A2 catalytic domain modulates association and residence time at Golgi membranes.
  J Biol Chem, 279, 6005-6016.  
15140198 J.Yoon, H.T.Leung, S.Lee, C.Geng, Y.Kim, K.Baek, and W.L.Pak (2004).
Specific molecular alterations in the norpA-encoded phospholipase C of Drosophila and their effects on electrophysiological responses in vivo.
  J Neurochem, 89, 998.  
14996830 X.Zhang, H.Wehbi, and M.F.Roberts (2004).
Cross-linking phosphatidylinositol-specific phospholipase C traps two activating phosphatidylcholine molecules on the enzyme.
  J Biol Chem, 279, 20490-20500.  
12576545 B.Zheng, C.P.Berrie, D.Corda, and M.G.Farquhar (2003).
GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors.
  Proc Natl Acad Sci U S A, 100, 1745-1750.  
14529272 C.Y.Kim, Y.D.Koo, J.B.Jin, B.C.Moon, C.H.Kang, S.T.Kim, B.O.Park, S.Y.Lee, M.L.Kim, I.Hwang, K.Y.Kang, J.D.Bahk, S.Y.Lee, and M.J.Cho (2003).
Rice C2-domain proteins are induced and translocated to the plasma membrane in response to a fungal elicitor.
  Biochemistry, 42, 11625-11633.  
12573692 J.H.Hurley (2003).
Membrane proteins: adapting to life at the interface.
  Chem Biol, 10, 2-3.  
12821674 J.S.McCullar, S.A.Larsen, R.A.Millimaki, and T.M.Filtz (2003).
Calmodulin is a phospholipase C-beta interacting protein.
  J Biol Chem, 278, 33708-33713.  
12657629 J.T.Snyder, A.U.Singer, M.R.Wing, T.K.Harden, and J.Sondek (2003).
The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.
  J Biol Chem, 278, 21099-21104.  
12662308 L.Hunt, L.N.Mills, C.Pical, C.P.Leckie, F.L.Aitken, J.Kopka, B.Mueller-Roeber, M.R.McAinsh, A.M.Hetherington, and J.E.Gray (2003).
Phospholipase C is required for the control of stomatal aperture by ABA.
  Plant J, 34, 47-55.  
12464611 M.Edman, S.Berg, P.Storm, M.Wikström, S.Vikström, A.Ohman, and A.Wieslander (2003).
Structural features of glycosyltransferases synthesizing major bilayer and nonbilayer-prone membrane lipids in Acholeplasma laidlawii and Streptococcus pneumoniae.
  J Biol Chem, 278, 8420-8428.  
14690594 M.J.Begley, G.S.Taylor, S.A.Kim, D.M.Veine, J.E.Dixon, and J.A.Stuckey (2003).
Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome.
  Mol Cell, 12, 1391-1402.
PDB codes: 1lw3 1m7r
12970180 M.Nishida, K.Sugimoto, Y.Hara, E.Mori, T.Morii, T.Kurosaki, and Y.Mori (2003).
Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes.
  EMBO J, 22, 4677-4688.  
12900402 M.R.Wing, J.T.Snyder, J.Sondek, and T.K.Harden (2003).
Direct activation of phospholipase C-epsilon by Rho.
  J Biol Chem, 278, 41253-41258.  
  12807776 R.Mankidy, J.Hastings, and J.R.Thackeray (2003).
Distinct phospholipase C-gamma-dependent signaling pathways in the Drosophila eye and wing are revealed by a new small wing allele.
  Genetics, 164, 553-563.  
12531893 R.V.Stahelin, J.D.Rafter, S.Das, and W.Cho (2003).
The molecular basis of differential subcellular localization of C2 domains of protein kinase C-alpha and group IVa cytosolic phospholipase A2.
  J Biol Chem, 278, 12452-12460.  
14529276 S.Corbalán-Garcia, S.Sánchez-Carrillo, J.García-García, and J.C.Gómez-Fernández (2003).
Characterization of the membrane binding mode of the C2 domain of PKC epsilon.
  Biochemistry, 42, 11661-11668.  
12930993 S.M.Singh, and D.Murray (2003).
Molecular modeling of the membrane targeting of phospholipase C pleckstrin homology domains.
  Protein Sci, 12, 1934-1953.  
12542690 S.W.Vetter, and E.Leclerc (2003).
Novel aspects of calmodulin target recognition and activation.
  Eur J Biochem, 270, 404-414.  
12761218 Y.Guo, F.Philip, and S.Scarlata (2003).
The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site.
  J Biol Chem, 278, 29995-30004.  
12805213 Y.Nakamura, K.Fukami, H.Yu, K.Takenaka, Y.Kataoka, Y.Shirakata, S.Nishikawa, K.Hashimoto, N.Yoshida, and T.Takenawa (2003).
Phospholipase Cdelta1 is required for skin stem cell lineage commitment.
  EMBO J, 22, 2981-2991.  
12009889 A.A.Frazier, M.A.Wisner, N.J.Malmberg, K.G.Victor, G.E.Fanucci, E.A.Nalefski, J.J.Falke, and D.S.Cafiso (2002).
Membrane orientation and position of the C2 domain from cPLA2 by site-directed spin labeling.
  Biochemistry, 41, 6282-6292.  
12296828 M.Okada, M.Fujii, M.Yamaga, H.Sugimoto, H.Sadano, T.Osumi, H.Kamata, H.Hirata, and H.Yagisawa (2002).
Carboxyl-terminal basic amino acids in the X domain are essential for the nuclear import of phospholipase C delta1.
  Genes Cells, 7, 985-996.  
12122018 P.Mignon, J.Steyaert, R.Loris, P.Geerlings, and S.Loverix (2002).
A nucleophile activation dyad in ribonucleases. A combined X-ray crystallographic/ab initio quantum chemical study.
  J Biol Chem, 277, 36770-36774.
PDB codes: 1lov 1low 1loy
11331007 A.V.Kravchuk, L.Zhao, R.J.Kubiak, K.S.Bruzik, and M.D.Tsai (2001).
Mechanism of phosphatidylinositol-specific phospholipase C: origin of unusually high nonbridging thio effects.
  Biochemistry, 40, 5433-5439.  
11684018 J.Bravo, D.Karathanassis, C.M.Pacold, M.E.Pacold, C.D.Ellson, K.E.Anderson, P.J.Butler, I.Lavenir, O.Perisic, P.T.Hawkins, L.Stephens, and R.L.Williams (2001).
The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.
  Mol Cell, 8, 829-839.
PDB code: 1h6h
11179977 J.García-García, J.C.Gómez-Fernández, and S.Corbalán-García (2001).
Structural characterization of the C2 domain of novel protein kinase Cepsilon.
  Eur J Biochem, 268, 1107-1117.  
  11641393 M.R.Wing, D.Houston, G.G.Kelley, C.J.Der, D.P.Siderovski, and T.K.Harden (2001).
Activation of phospholipase C-epsilon by heterotrimeric G protein betagamma-subunits.
  J Biol Chem, 276, 48257-48261.  
11737859 P.Van Dijken, and P.J.Van Haastert (2001).
Phospholipase Cdelta regulates germination of Dictyostelium spores.
  BMC Cell Biol, 2, 25.  
11325731 R.Galneder, V.Kahl, A.Arbuzova, M.Rebecchi, J.O.Rädler, and S.McLaughlin (2001).
Microelectrophoresis of a bilayer-coated silica bead in an optical trap: application to enzymology.
  Biophys J, 80, 2298-2309.  
11395409 S.G.Rhee (2001).
Regulation of phosphoinositide-specific phospholipase C.
  Annu Rev Biochem, 70, 281-312.  
11337397 X.Wang (2001).
  Annu Rev Plant Physiol Plant Mol Biol, 52, 211-231.  
10673441 A.Dessen (2000).
Phospholipase A(2) enzymes: structural diversity in lipid messenger metabolism.
  Structure, 8, R15-R22.  
10634937 A.G.Buckland, and D.C.Wilton (2000).
Anionic phospholipids, interfacial binding and the regulation of cell functions.
  Biochim Biophys Acta, 1483, 199-216.  
10677230 A.J.Barr, H.Ali, B.Haribabu, R.Snyderman, and A.V.Smrcka (2000).
Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits.
  Biochemistry, 39, 1800-1806.  
11094067 B.J.Irvin, B.L.Williams, A.E.Nilson, H.O.Maynor, and R.T.Abraham (2000).
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.
  Mol Cell Biol, 20, 9149-9161.  
10966476 E.M.Ross, and T.M.Wilkie (2000).
GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.
  Annu Rev Biochem, 69, 795-827.  
10873862 I.Leiros, F.Secundo, C.Zambonelli, S.Servi, and E.Hough (2000).
The first crystal structure of a phospholipase D.
  Structure, 8, 655-667.
PDB code: 1f0i
10940243 J.H.Hurley, and S.Misra (2000).
Signaling and subcellular targeting by membrane-binding domains.
  Annu Rev Biophys Biomol Struct, 29, 49-79.  
11114512 J.H.Hurley, Y.Tsujishita, and M.A.Pearson (2000).
Floundering about at cell membranes: a structural view of phospholipid signaling.
  Curr Opin Struct Biol, 10, 737-743.  
10601847 K.Fukami, K.Takenaka, K.Nagano, and T.Takenawa (2000).
Growth factor-induced promoter activation of murine phospholipase C delta4 gene.
  Eur J Biochem, 267, 28-36.  
11015230 K.N.Burger, R.A.Demel, S.L.Schmid, and Kruijff (2000).
Dynamin is membrane-active: lipid insertion is induced by phosphoinositides and phosphatidic acid.
  Biochemistry, 39, 12485-12493.  
10811903 R.A.García, C.E.Forde, and H.A.Godwin (2000).
Calcium triggers an intramolecular association of the C2 domains in synaptotagmin.
  Proc Natl Acad Sci U S A, 97, 5883-5888.  
10865129 R.R.Duncan, M.J.Shipston, and R.H.Chow (2000).
Double C2 protein. A review.
  Biochimie, 82, 421-426.  
10715114 S.Sugita, and T.C.Südhof (2000).
Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins.
  Biochemistry, 39, 2940-2949.  
10692446 T.Furuya, C.Kashuba, R.Docampo, and S.N.Moreno (2000).
A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation.
  J Biol Chem, 275, 6428-6438.  
10785396 T.Kanematsu, K.Yoshimura, K.Hidaka, H.Takeuchi, M.Katan, and M.Hirata (2000).
Domain organization of p130, PLC-related catalytically inactive protein, and structural basis for the lack of enzyme activity.
  Eur J Biochem, 267, 2731-2737.  
10713048 T.Wang, L.Dowal, M.R.El-Maghrabi, M.Rebecchi, and S.Scarlata (2000).
The pleckstrin homology domain of phospholipase C-beta(2) links the binding of gbetagamma to activation of the catalytic core.
  J Biol Chem, 275, 7466-7469.  
10775762 X.Wang (2000).
Multiple forms of phospholipase D in plants: the gene family, catalytic and regulatory properties, and cellular functions.
  Prog Lipid Res, 39, 109-149.  
10400317 A.Chow, A.J.Davis, and D.J.Gawler (1999).
Investigating the role played by protein-lipid and protein-protein interactions in the membrane association of the p120GAP CaLB domain.
  Cell Signal, 11, 443-451.  
10319815 A.Dessen, J.Tang, H.Schmidt, M.Stahl, J.D.Clark, J.Seehra, and W.S.Somers (1999).
Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.
  Cell, 97, 349-360.
PDB code: 1cjy
10446181 A.Morrione, P.Plant, B.Valentinis, O.Staub, S.Kumar, D.Rotin, and R.Baserga (1999).
mGrb10 interacts with Nedd4.
  J Biol Chem, 274, 24094-24099.  
10353474 F.Russo-Marie (1999).
Annexin V and phospholipid metabolism.
  Clin Chem Lab Med, 37, 287-291.  
10371466 H.LeVine (1999).
Structural features of heterotrimeric G-protein-coupled receptors and their modulatory proteins.
  Mol Neurobiol, 19, 111-149.  
10570245 H.van Tilbeurgh, S.Bezzine, C.Cambillau, R.Verger, and F.Carrière (1999).
Colipase: structure and interaction with pancreatic lipase.
  Biochim Biophys Acta, 1441, 173-184.  
10555148 J.O.Lee, H.Yang, M.M.Georgescu, A.Di Cristofano, T.Maehama, Y.Shi, J.E.Dixon, P.Pandolfi, and N.P.Pavletich (1999).
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
  Cell, 99, 323-334.
PDB code: 1d5r
10419523 J.W.Lomasney, H.F.Cheng, S.R.Roffler, and K.King (1999).
Activation of phospholipase C delta1 through C2 domain by a Ca(2+)-enzyme-phosphatidylserine ternary complex.
  J Biol Chem, 274, 21995-22001.  
10591109 K.L.Yap, J.B.Ames, M.B.Swindells, and M.Ikura (1999).
Diversity of conformational states and changes within the EF-hand protein superfamily.
  Proteins, 37, 499-507.  
9915823 K.Nagano, K.Fukami, T.Minagawa, Y.Watanabe, C.Ozaki, and T.Takenawa (1999).
A novel phospholipase C delta4 (PLCdelta4) splice variant as a negative regulator of PLC.
  J Biol Chem, 274, 2872-2879.  
10425392 K.Pappan, and X.Wang (1999).
Molecular and biochemical properties and physiological roles of plant phospholipase D.
  Biochim Biophys Acta, 1439, 151-166.  
9931014 L.W.Runnels, and S.F.Scarlata (1999).
Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-beta effectors.
  Biochemistry, 38, 1488-1496.  
10497218 M.Yamaga, M.Fujii, H.Kamata, H.Hirata, and H.Yagisawa (1999).
Phospholipase C-delta1 contains a functional nuclear export signal sequence.
  J Biol Chem, 274, 28537-28541.  
10562545 N.Verdaguer, S.Corbalan-Garcia, W.F.Ochoa, I.Fita, and J.C.Gómez-Fernández (1999).
Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine.
  EMBO J, 18, 6329-6338.
PDB code: 1dsy
10329700 O.Perisic, H.F.Paterson, G.Mosedale, S.Lara-González, and R.L.Williams (1999).
Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2.
  J Biol Chem, 274, 14979-14987.  
10570253 R.L.Williams (1999).
Mammalian phosphoinositide-specific phospholipase C.
  Biochim Biophys Acta, 1441, 255-267.  
10090770 S.J.Slater, S.K.Milano, B.A.Stagliano, K.J.Gergich, C.Ho, A.Mazurek, F.J.Taddeo, M.B.Kelly, M.D.Yeager, and C.D.Stubbs (1999).
Synergistic activation of protein kinase Calpha, -betaI, and -gamma isoforms induced by diacylglycerol and phorbol ester: roles of membrane association and activating conformational changes.
  Biochemistry, 38, 3804-3815.  
  9864213 T.Bannam, and H.Goldfine (1999).
Mutagenesis of active-site histidines of Listeria monocytogenes phosphatidylinositol-specific phospholipase C: effects on enzyme activity and biological function.
  Infect Immun, 67, 182-186.  
10336610 T.Pawelczyk, and A.Matecki (1999).
Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes.
  Eur J Biochem, 262, 291-298.  
9931017 T.Wang, S.Pentyala, M.J.Rebecchi, and S.Scarlata (1999).
Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins.
  Biochemistry, 38, 1517-1524.  
10491207 T.Yamamoto, H.Takeuchi, T.Kanematsu, V.Allen, H.Yagisawa, U.Kikkawa, Y.Watanabe, A.Nakasima, M.Katan, and M.Hirata (1999).
Involvement of EF hand motifs in the Ca(2+)-dependent binding of the pleckstrin homology domain to phosphoinositides.
  Eur J Biochem, 265, 481-490.  
10473563 Y.H.Kim, T.J.Park, Y.H.Lee, K.J.Baek, P.G.Suh, S.H.Ryu, and K.T.Kim (1999).
Phospholipase C-delta1 is activated by capacitative calcium entry that follows phospholipase C-beta activation upon bradykinin stimulation.
  J Biol Chem, 274, 26127-26134.  
9668093 B.Davletov, O.Perisic, and R.L.Williams (1998).
Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.
  J Biol Chem, 273, 19093-19096.  
9507029 B.Sankaran, J.Osterhout, D.Wu, and A.V.Smrcka (1998).
Identification of a structural element in phospholipase C beta2 that interacts with G protein betagamma subunits.
  J Biol Chem, 273, 7148-7154.  
9430674 C.E.Creutz, J.L.Tomsig, S.L.Snyder, M.C.Gautier, F.Skouri, J.Beisson, and J.Cohen (1998).
The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans.
  J Biol Chem, 273, 1393-1402.  
9699639 C.E.Naylor, J.T.Eaton, A.Howells, N.Justin, D.S.Moss, R.W.Titball, and A.K.Basak (1998).
Structure of the key toxin in gas gangrene.
  Nat Struct Biol, 5, 738-746.
PDB code: 1ca1
9922129 E.A.Nalefski, and J.J.Falke (1998).
Location of the membrane-docking face on the Ca2+-activated C2 domain of cytosolic phospholipase A2.
  Biochemistry, 37, 17642-17650.  
9430670 E.A.Nalefski, T.McDonagh, W.Somers, J.Seehra, J.J.Falke, and J.D.Clark (1998).
Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2.
  J Biol Chem, 273, 1365-1372.  
9593749 E.R.Chapman, and A.F.Davis (1998).
Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers.
  J Biol Chem, 273, 13995-14001.  
9830048 E.R.Chapman, R.C.Desai, A.F.Davis, and C.K.Tornehl (1998).
Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin.
  J Biol Chem, 273, 32966-32972.  
9687370 H.Pappa, J.Murray-Rust, L.V.Dekker, P.J.Parker, and N.Q.McDonald (1998).
Crystal structure of the C2 domain from protein kinase C-delta.
  Structure, 6, 885-894.
PDB code: 1bdy
9871707 H.S.Hendrickson, and E.K.Hendrickson (1998).
A thiophosphate analog of dimyristoylphosphatidyl-inositol-4-phosphate is a substrate for mammalian phosphoinositide-specific phospholipase C.
  Bioorg Med Chem Lett, 8, 1057-1060.  
9417098 H.Yagisawa, K.Sakuma, H.F.Paterson, R.Cheung, V.Allen, H.Hirata, Y.Watanabe, M.Hirata, R.L.Williams, and M.Katan (1998).
Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane.
  J Biol Chem, 273, 417-424.  
9538021 J.A.Grobler, and J.H.Hurley (1998).
Catalysis by phospholipase C delta1 requires that Ca2+ bind to the catalytic domain, but not the C2 domain.
  Biochemistry, 37, 5020-5028.  
9667926 J.Evenäs, A.Malmendal, and S.Forsén (1998).
  Curr Opin Chem Biol, 2, 293-302.  
9632630 J.Rizo, and T.C.Südhof (1998).
C2-domains, structure and function of a universal Ca2+-binding domain.
  J Biol Chem, 273, 15879-15882.  
9670009 J.Ubach, X.Zhang, X.Shao, T.C.Südhof, and J.Rizo (1998).
Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?
  EMBO J, 17, 3921-3930.  
9782057 L.Serre, B.Vallée, N.Bureaud, F.Schoentgen, and C.Zelwer (1998).
Crystal structure of the phosphatidylethanolamine-binding protein from bovine brain: a novel structural class of phospholipid-binding proteins.
  Structure, 6, 1255-1265.
PDB codes: 1a44 1b7a
9430633 M.Falasca, S.K.Logan, V.P.Lehto, G.Baccante, M.A.Lemmon, and J.Schlessinger (1998).
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.
  EMBO J, 17, 414-422.  
9593218 M.Hirata, T.Kanematsu, H.Takeuchi, and H.Yagisawa (1998).
Pleckstrin homology domain as an inositol compound binding module.
  Jpn J Pharmacol, 76, 255-263.  
9838094 M.J.Bottomley, K.Salim, and G.Panayotou (1998).
Phospholipid-binding protein domains.
  Biochim Biophys Acta, 1436, 165-183.  
9646876 M.J.Rebecchi, and S.Scarlata (1998).
Pleckstrin homology domains: a common fold with diverse functions.
  Annu Rev Biophys Biomol Struct, 27, 503-528.  
9838022 M.Katan (1998).
Families of phosphoinositide-specific phospholipase C: structure and function.
  Biochim Biophys Acta, 1436, 5.  
9651347 M.Medkova, and W.Cho (1998).
Mutagenesis of the C2 domain of protein kinase C-alpha. Differential roles of Ca2+ ligands and membrane binding residues.
  J Biol Chem, 273, 17544-17552.  
9442060 M.Mosior, D.A.Six, and E.A.Dennis (1998).
Group IV cytosolic phospholipase A2 binds with high affinity and specificity to phosphatidylinositol 4,5-bisphosphate resulting in dramatic increases in activity.
  J Biol Chem, 273, 2184-2191.  
9622504 M.S.Hixon, A.Ball, and M.H.Gelb (1998).
Calcium-dependent and -independent interfacial binding and catalysis of cytosolic group IV phospholipase A2.
  Biochemistry, 37, 8516-8526.  
9497345 M.Shibatohge, K.Kariya, Y.Liao, C.D.Hu, Y.Watari, M.Goshima, F.Shima, and T.Kataoka (1998).
Identification of PLC210, a Caenorhabditis elegans phospholipase C, as a putative effector of Ras.
  J Biol Chem, 273, 6218-6222.  
9565585 M.V.Ellis, S.R.James, O.Perisic, C.P.Downes, R.L.Williams, and M.Katan (1998).
Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1.
  J Biol Chem, 273, 11650-11659.  
9430701 O.Perisic, S.Fong, D.E.Lynch, M.Bycroft, and R.L.Williams (1998).
Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2.
  J Biol Chem, 273, 1596-1604.
PDB code: 1rlw
  9529375 Q.S.Ji, S.Ermini, J.Baulida, F.L.Sun, and G.Carpenter (1998).
Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts.
  Mol Biol Cell, 9, 749-757.  
9666333 R.B.Russell, and C.P.Ponting (1998).
Protein fold irregularities that hinder sequence analysis.
  Curr Opin Struct Biol, 8, 364-371.  
9817842 R.B.Sutton, and S.R.Sprang (1998).
Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+.
  Structure, 6, 1395-1405.
PDB code: 1a25
9707392 R.Irvine (1998).
Inositol phospholipids: translocation, translocation, translocation...
  Curr Biol, 8, R557-R559.  
9521777 R.J.Hondal, Z.Zhao, A.V.Kravchuk, H.Liao, S.R.Riddle, X.Yue, K.S.Bruzik, and M.D.Tsai (1998).
Mechanism of phosphatidylinositol-specific phospholipase C: a unified view of the mechanism of catalysis.
  Biochemistry, 37, 4568-4580.  
9871708 S.G.Aneja, P.T.Ivanova, and R.Aneja (1998).
Synthesis of 2-deoxy-2-fluoro-phosphatidylinositol-4,5-bisphosphate and analogues: probes and modulators of the mammalian PI-PLCS.
  Bioorg Med Chem Lett, 8, 1061-1064.  
9714794 S.Wang, Y.Zhou, A.Lukinius, K.Oberg, B.Skogseid, and A.Gobl (1998).
Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3.
  Biochim Biophys Acta, 1393, 173-178.  
9651677 T.P.Levine, and S.Munro (1998).
The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes.
  Curr Biol, 8, 729-739.  
9753329 V.D.Rao, S.Misra, I.V.Boronenkov, R.A.Anderson, and J.H.Hurley (1998).
Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.
  Cell, 94, 829-839.
PDB code: 1bo1
9819203 X.Shao, I.Fernandez, T.C.Südhof, and J.Rizo (1998).
Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?
  Biochemistry, 37, 16106-16115.
PDB code: 1byn
9730811 X.Zhang, J.Rizo, and T.C.Südhof (1998).
Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I.
  Biochemistry, 37, 12395-12403.  
9506941 Y.Lin, R.Nielsen, D.Murray, W.L.Hubbell, C.Mailer, B.H.Robinson, and M.H.Gelb (1998).
Docking phospholipase A2 on membranes using electrostatic potential-modulated spin relaxation magnetic resonance.
  Science, 279, 1925-1929.  
9069266 A.C.Newton (1997).
Regulation of protein kinase C.
  Curr Opin Cell Biol, 9, 161-167.  
9244406 A.Kamat, and G.Carpenter (1997).
Phospholipase C-gamma1: regulation of enzyme function and role in growth factor-dependent signal transduction.
  Cytokine Growth Factor Rev, 8, 109-117.  
9251249 A.Matecki, M.Stopa, A.Was, and T.Pawelczyk (1997).
Effect of sphingomyelin and its metabolites on the activity of human recombinant PLC delta 1.
  Int J Biochem Cell Biol, 29, 815-828.  
9032078 C.S.Bond, P.R.Clements, S.J.Ashby, C.A.Collyer, S.J.Harrop, J.J.Hopwood, and J.M.Guss (1997).
Structure of a human lysosomal sulfatase.
  Structure, 5, 277-289.
PDB code: 1fsu
9335537 C.S.Gässler, M.Ryan, T.Liu, O.H.Griffith, and D.W.Heinz (1997).
Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis.
  Biochemistry, 36, 12802-12813.
PDB codes: 2ptd 3ptd 4ptd 5ptd 6ptd 7ptd
9279125 D.da Graça Thrige, J.R.Buur, and F.S.Jørgensen (1997).
Substrate binding and catalytic mechanism in phospholipase C from Bacillus cereus: a molecular mechanics and molecular dynamics study.
  Biopolymers, 42, 319-336.  
9340010 E.A.Nalefski, M.M.Slazas, and J.J.Falke (1997).
Ca2+-signaling cycle of a membrane-docking C2 domain.
  Biochemistry, 36, 12011-12018.  
9391158 E.A.Richard, S.Ghosh, J.M.Lowenstein, and J.E.Lisman (1997).
Ca2+/calmodulin-binding peptides block phototransduction in Limulus ventral photoreceptors: evidence for direct inhibition of phospholipase C.
  Proc Natl Acad Sci U S A, 94, 14095-14099.  
9188725 E.Tall, G.Dormán, P.Garcia, L.Runnels, S.Shah, J.Chen, A.Profit, Q.M.Gu, A.Chaudhary, G.D.Prestwich, and M.J.Rebecchi (1997).
Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs.
  Biochemistry, 36, 7239-7248.  
9095190 J.A.Grobler, and J.H.Hurley (1997).
Similarity between C2 domain jaws and immunoglobulin CDRs.
  Nat Struct Biol, 4, 261-262.  
9030716 J.H.Exton (1997).
Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases.
  Eur J Biochem, 243, 10-20.  
9266179 J.H.Hurley, and J.A.Grobler (1997).
Protein kinase C and phospholipase C: bilayer interactions and regulation.
  Curr Opin Struct Biol, 7, 557-565.  
9096299 J.Schlessinger (1997).
Phospholipase Cgamma activation and phosphoinositide hydrolysis are essential for embryonal development.
  Proc Natl Acad Sci U S A, 94, 2798-2799.  
9032077 L.Holm, and C.Sander (1997).
New structure--novel fold?
  Structure, 5, 165-171.  
  17708952 L.M A, F.M, S.J, and F.K (1997).
Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains.
  Trends Cell Biol, 7, 237-242.  
9062102 L.O.Essen, O.Perisic, D.E.Lynch, M.Katan, and R.L.Williams (1997).
A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.
  Biochemistry, 36, 2753-2762.
PDB codes: 1djg 1djh 1dji
9048554 L.O.Essen, O.Perisic, M.Katan, Y.Wu, M.F.Roberts, and R.L.Williams (1997).
Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C.
  Biochemistry, 36, 1704-1718.
PDB codes: 1djw 1djx 1djy 1djz
  9253765 M.Mosior, and R.M.Epand (1997).
Protein kinase C: an example of a calcium-regulated protein binding to membranes (review).
  Mol Membr Biol, 14, 65-70.  
9405440 P.J.Plant, H.Yeger, O.Staub, P.Howard, and D.Rotin (1997).
The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization.
  J Biol Chem, 272, 32329-32336.  
9184143 R.J.Hondal, S.R.Riddle, A.V.Kravchuk, Z.Zhao, H.Liao, K.S.Bruzik, and M.D.Tsai (1997).
Phosphatidylinositol-specific phospholipase C: kinetic and stereochemical evidence for an interaction between arginine-69 and the phosphate group of phosphatidylinositol.
  Biochemistry, 36, 6633-6642.  
9182519 S.G.Rhee, and Y.S.Bae (1997).
Regulation of phosphoinositide-specific phospholipase C isozymes.
  J Biol Chem, 272, 15045-15048.  
  9300493 T.Liu, M.Ryan, F.W.Dahlquist, and O.H.Griffith (1997).
Determination of pKa values of the histidine side chains of phosphatidylinositol-specific phospholipase C from Bacillus cereus by NMR spectroscopy and site-directed mutagenesis.
  Protein Sci, 6, 1937-1944.  
9346303 T.Pawelczyk, and A.Matecki (1997).
Structural requirements of phospholipase C delta1 for regulation by spermine, sphingosine and sphingomyelin.
  Eur J Biochem, 248, 459-465.  
9242915 W.D.Singer, H.A.Brown, and P.C.Sternweis (1997).
Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D.
  Annu Rev Biochem, 66, 475-509.  
9353280 W.Qin, K.Pappan, and X.Wang (1997).
Molecular heterogeneity of phospholipase D (PLD). Cloning of PLDgamma and regulation of plant PLDgamma, -beta, and -alpha by polyphosphoinositides and calcium.
  J Biol Chem, 272, 28267-28273.  
9204286 Y.Lindqvist, and G.Schneider (1997).
Circular permutations of natural protein sequences: structural evidence.
  Curr Opin Struct Biol, 7, 422-427.  
9214296 Y.Wu, and M.F.Roberts (1997).
Phosphatidylinositol-specific phospholipase C cyclic phosphodiesterase activity depends on solvent polarity.
  Biochemistry, 36, 8514-8521.  
9287165 Y.Wu, O.Perisic, R.L.Williams, M.Katan, and M.F.Roberts (1997).
Phosphoinositide-specific phospholipase C delta1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation.
  Biochemistry, 36, 11223-11233.  
  8976547 E.A.Nalefski, and J.J.Falke (1996).
The C2 domain calcium-binding motif: structural and functional diversity.
  Protein Sci, 5, 2375-2390.  
8784353 J.A.Grobler, L.O.Essen, R.L.Williams, and J.H.Hurley (1996).
C2 domain conformational changes in phospholipase C-delta 1.
  Nat Struct Biol, 3, 788-795.
PDB codes: 1qas 1qat
8955136 J.C.Loijens, and R.A.Anderson (1996).
Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.
  J Biol Chem, 271, 32937-32943.  
8798711 L.P.Wang, C.Lim, Y.Kuan, C.L.Chen, H.F.Chen, and K.King (1996).
Positive charge at position 549 is essential for phosphatidylinositol 4,5-bisphosphate-hydrolyzing but not phosphatidylinositol-hydrolyzing activities of human phospholipase C delta1.
  J Biol Chem, 271, 24505-24516.  
8824266 M.Glaser, S.Wanaski, C.A.Buser, V.Boguslavsky, W.Rashidzada, A.Morris, M.Rebecchi, S.F.Scarlata, L.W.Runnels, G.D.Prestwich, J.Chen, A.Aderem, J.Ahn, and S.McLaughlin (1996).
Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains.
  J Biol Chem, 271, 26187-26193.  
  8816504 R.A.Klinghoffer, B.Duckworth, M.Valius, L.Cantley, and A.Kazlauskas (1996).
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity.
  Mol Cell Biol, 16, 5905-5914.  
8900136 R.H.Paulssen, J.Woodson, Z.Liu, and E.M.Ross (1996).
Carboxyl-terminal fragments of phospholipase C-beta1 with intrinsic Gq GTPase-activating protein (GAP) activity.
  J Biol Chem, 271, 26622-26629.  
8994965 R.L.Williams, and M.Katan (1996).
Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead.
  Structure, 4, 1387-1394.  
8942652 S.Scarlata, R.Gupta, P.Garcia, H.Keach, S.Shah, C.R.Kasireddy, R.Bittman, and M.J.Rebecchi (1996).
Inhibition of phospholipase C-delta 1 catalytic activity by sphingomyelin.
  Biochemistry, 35, 14882-14888.  
8898867 T.Dubois, J.P.Oudinet, J.P.Mira, and F.Russo-Marie (1996).
Annexins and protein kinases C.
  Biochim Biophys Acta, 1313, 290-294.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.