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PDBsum entry 2i6l

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protein Protein-protein interface(s) links
Transferase PDB id
2i6l
Jmol
Contents
Protein chains
292 a.a. *
269 a.a. *
Waters ×79
* Residue conservation analysis
PDB id:
2i6l
Name: Transferase
Title: Crystal structure of human mitogen activated protein kinase 6 (mapk6)
Structure: Mitogen-activated protein kinase 6. Chain: a, b. Synonym: extracellular signal-regulated kinase 3, erk-3, map kinase isoform p97, p97- mapk. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk6, erk3, prkm6. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.25Å     R-factor:   0.224     R-free:   0.272
Authors: P.Filippakopoulos,A.P.Turnbull,P.Savitsky,O.Fedorov, G.Berridge,S.Das,J.Elkins,M.Soundararajan,X.W.Yang,D.Doyle, E.Papagrigoriou,A.C.W.Pike,G.Bunkonczi,E.Ugochukwu, J.Debreczeni,F.Von Delft,A.Edwards,C.Arrowsmith,M.Sundstrom S.Knapp,Structural Genomics Consortium (Sgc)
Key ref: P.Filippakopoulos et al. Crystal structure of the human mitogen activated protein kinase 6. To be published, .
Date:
29-Aug-06     Release date:   12-Sep-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16659  (MK06_HUMAN) -  Mitogen-activated protein kinase 6
Seq:
Struc:
 
Seq:
Struc:
721 a.a.
292 a.a.*
Protein chain
Pfam   ArchSchema ?
Q16659  (MK06_HUMAN) -  Mitogen-activated protein kinase 6
Seq:
Struc:
 
Seq:
Struc:
721 a.a.
269 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     5 terms