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Actin-binding protein
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PDB id
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2i2q
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* Residue conservation analysis
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Gene Ontology (GO) functional annotation
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Cellular component
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intracellular
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8 terms
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Biological process
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cell cycle
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4 terms
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Biochemical function
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actin binding
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1 term
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DOI no:
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Mol Cell
24:13-23
(2006)
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PubMed id:
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Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin.
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E.Andrianantoandro,
T.D.Pollard.
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ABSTRACT
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ADF/cofilins are key regulators of actin dynamics during cellular motility, yet
their precise role and mechanism of action are shrouded in ambiguity. Direct
observation of actin filaments by evanescent wave microscopy showed that
cofilins from fission yeast and human do not increase the rate that pointed ends
of actin filaments shorten beyond the rate for ADP-actin subunits, but both
cofilins inhibit elongation and subunit dissociation at barbed ends. Direct
observation also showed that cofilins from fission yeast, Acanthamoeba, and
human sever actin filaments optimally at low-cofilin binding densities well
below their K(d)s, but not at high binding densities. High concentrations of
cofilin nucleate actin assembly. Thus, the action of cofilins in cells will
depend on the local concentration of active cofilins: low concentrations favor
severing, whereas high concentrations favor nucleation. These results establish
a clear paradigm for actin turnover by cofilin in cells.
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Selected figure(s)
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Figure 1.
Figure 1. Actin Filament Severing by Cofilins Observed by
Evanescent Wave Fluorescence Microscopy
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Figure 4.
Figure 4. Effect of Cofilins on Actin Filament Elongation
and Nucleation
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The above figures are
reprinted
by permission from Cell Press:
Mol Cell
(2006,
24,
13-23)
copyright 2006.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
|
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| |
PubMed id
|
|
Reference
|
|
|
|
|
|
A.Goyal,
M.Takaine,
V.Simanis,
and
K.Nakano
(2011).
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|
| |
Cytoskeleton (Hoboken), 68,
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|
|
|
|
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|
A.Molnar,
J.Haybaeck,
C.Lackner,
and
P.Strnad
(2011).
The cytoskeleton in nonalcoholic steatohepatitis: 100 years old but still youthful.
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| |
Expert Rev Gastroenterol Hepatol, 5,
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|
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|
|
A.Muhlrad,
E.E.Grintsevich,
and
E.Reisler
(2011).
Polycation induced actin bundles.
|
| |
Biophys Chem, 155,
45-51.
|
|
|
|
|
|
|
B.Stuhrmann,
F.Huber,
and
J.Käs
(2011).
Robust organizational principles of protrusive biopolymer networks in migrating living cells.
|
| |
PLoS One, 6,
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|
D.R.Kovar,
V.Sirotkin,
and
M.Lord
(2011).
Three's company: the fission yeast actin cytoskeleton.
|
| |
Trends Cell Biol, 21,
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|
N.Tania,
E.Prosk,
J.Condeelis,
and
L.Edelstein-Keshet
(2011).
A temporal model of cofilin regulation and the early peak of actin barbed ends in invasive tumor cells.
|
| |
Biophys J, 100,
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|
Y.Zhang,
Y.Xiao,
F.Du,
L.Cao,
H.Dong,
and
H.Ren
(2011).
Arabidopsis VILLIN4 is involved in root hair growth through regulating actin organization in a Ca2+-dependent manner.
|
| |
New Phytol, 190,
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A.W.Serio,
R.L.Jeng,
C.M.Haglund,
S.C.Reed,
and
M.D.Welch
(2010).
Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia.
|
| |
Cell Host Microbe, 7,
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|
B.M.Marsick,
K.C.Flynn,
M.Santiago-Medina,
J.R.Bamburg,
and
P.C.Letourneau
(2010).
Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1.
|
| |
Dev Neurobiol, 70,
565-588.
|
|
|
|
|
|
|
B.W.Bernstein,
and
J.R.Bamburg
(2010).
ADF/cofilin: a functional node in cell biology.
|
| |
Trends Cell Biol, 20,
187-195.
|
|
|
|
|
|
|
C.J.Staiger,
N.S.Poulter,
J.L.Henty,
V.E.Franklin-Tong,
and
L.Blanchoin
(2010).
Regulation of actin dynamics by actin-binding proteins in pollen.
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| |
J Exp Bot, 61,
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C.W.Lin,
S.T.Yen,
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S.J.Chen,
S.L.Lai,
Y.C.Liu,
T.H.Chan,
W.L.Liao,
and
S.J.Lee
(2010).
Loss of cofilin 1 disturbs actin dynamics, adhesion between enveloping and deep cell layers and cell movements during gastrulation in zebrafish.
|
| |
PLoS One, 5,
e15331.
|
|
|
|
|
|
|
E.M.De La Cruz,
and
D.Sept
(2010).
The kinetics of cooperative cofilin binding reveals two states of the cofilin-actin filament.
|
| |
Biophys J, 98,
1893-1901.
|
|
|
|
|
|
|
H.G.Mannherz,
A.J.Mazur,
and
B.Jockusch
(2010).
Repolymerization of actin from actin:thymosin beta4 complex induced by diaphanous related formins and gelsolin.
|
| |
Ann N Y Acad Sci, 1194,
36-43.
|
|
|
|
|
|
|
H.Zhao,
M.Hakala,
and
P.Lappalainen
(2010).
ADF/cofilin binds phosphoinositides in a multivalent manner to act as a PIP(2)-density sensor.
|
| |
Biophys J, 98,
2327-2336.
|
|
|
|
|
|
|
J.Berro,
V.Sirotkin,
and
T.D.Pollard
(2010).
Mathematical modeling of endocytic actin patch kinetics in fission yeast: disassembly requires release of actin filament fragments.
|
| |
Mol Biol Cell, 21,
2905-2915.
|
|
|
|
|
|
|
J.Yao,
T.Hennessey,
A.Flynt,
E.Lai,
M.F.Beal,
and
M.T.Lin
(2010).
MicroRNA-related cofilin abnormality in Alzheimer's disease.
|
| |
PLoS One, 5,
e15546.
|
|
|
|
|
|
|
J.d.e. .A.Engler,
N.Rodiuc,
A.Smertenko,
and
P.Abad
(2010).
Plant actin cytoskeleton re-modeling by plant parasitic nematodes.
|
| |
Plant Signal Behav, 5,
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|
|
|
|
|
|
|
L.S.Minamide,
S.Maiti,
J.A.Boyle,
R.C.Davis,
J.A.Coppinger,
Y.Bao,
T.Y.Huang,
J.Yates,
G.M.Bokoch,
and
J.R.Bamburg
(2010).
Isolation and characterization of cytoplasmic cofilin-actin rods.
|
| |
J Biol Chem, 285,
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|
|
|
|
|
|
|
M.Bender,
A.Eckly,
J.H.Hartwig,
M.Elvers,
I.Pleines,
S.Gupta,
G.Krohne,
E.Jeanclos,
A.Gohla,
C.Gurniak,
C.Gachet,
W.Witke,
and
B.Nieswandt
(2010).
ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing.
|
| |
Blood, 116,
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|
M.Quintela-Fandino,
A.González-Martín,
and
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(2010).
Targeting cytoskeleton reorganisation as antimetastatic treatment.
|
| |
Clin Transl Oncol, 12,
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|
N.Watanabe
(2010).
Inside view of cell locomotion through single-molecule: fast F-/G-actin cycle and G-actin regulation of polymer restoration.
|
| |
Proc Jpn Acad Ser B Phys Biol Sci, 86,
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|
|
|
|
|
|
|
P.J.Michalski,
and
A.E.Carlsson
(2010).
The effects of filament aging and annealing on a model lamellipodium undergoing disassembly by severing.
|
| |
Phys Biol, 7,
026004.
|
|
|
|
|
|
|
S.Kuure,
C.Cebrian,
Q.Machingo,
B.C.Lu,
X.Chi,
D.Hyink,
V.D'Agati,
C.Gurniak,
W.Witke,
and
F.Costantini
(2010).
Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis.
|
| |
PLoS Genet, 6,
e1001176.
|
|
|
|
|
|
|
S.Mehta,
and
L.D.Sibley
(2010).
Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin.
|
| |
J Biol Chem, 285,
6835-6847.
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|
T.D.Bunney,
and
M.Katan
(2010).
Phosphoinositide signalling in cancer: beyond PI3K and PTEN.
|
| |
Nat Rev Cancer, 10,
342-352.
|
|
|
|
|
|
|
T.D.Pollard
(2010).
A guide to simple and informative binding assays.
|
| |
Mol Biol Cell, 21,
4061-4067.
|
|
|
|
|
|
|
V.Okreglak,
and
D.G.Drubin
(2010).
Loss of Aip1 reveals a role in maintaining the actin monomer pool and an in vivo oligomer assembly pathway.
|
| |
J Cell Biol, 188,
769-777.
|
|
|
|
|
|
|
Z.Wang,
M.Wang,
and
B.I.Carr
(2010).
Involvement of receptor tyrosine phosphatase DEP-1 mediated PI3K-cofilin signaling pathway in sorafenib-induced cytoskeletal rearrangement in hepatoma cells.
|
| |
J Cell Physiol, 224,
559-565.
|
|
|
|
|
|
|
A.Giorgi,
L.Di Francesco,
S.Principe,
G.Mignogna,
L.Sennels,
C.Mancone,
T.Alonzi,
M.Sbriccoli,
A.De Pascalis,
J.Rappsilber,
F.Cardone,
M.Pocchiari,
B.Maras,
and
M.E.Schininà
(2009).
Proteomic profiling of PrP27-30-enriched preparations extracted from the brain of hamsters with experimental scrapie.
|
| |
Proteomics, 9,
3802-3814.
|
|
|
|
|
|
|
A.S.Paul,
and
T.D.Pollard
(2009).
Review of the mechanism of processive actin filament elongation by formins.
|
| |
Cell Motil Cytoskeleton, 66,
606-617.
|
|
|
|
|
|
|
C.Erlenkämper,
and
K.Kruse
(2009).
Uncorrelated changes of subunit stability can generate length-dependent disassembly of treadmilling filaments.
|
| |
Phys Biol, 6,
46016.
|
|
|
|
|
|
|
C.G.Pontrello,
and
I.M.Ethell
(2009).
Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines.
|
| |
Open Neurosci J, 3,
67-86.
|
|
|
|
|
|
|
C.W.Lee,
J.Han,
J.R.Bamburg,
L.Han,
R.Lynn,
and
J.Q.Zheng
(2009).
Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular trafficking.
|
| |
Nat Neurosci, 12,
848-856.
|
|
|
|
|
|
|
E.M.De La Cruz
(2009).
How cofilin severs an actin filament.
|
| |
Biophys Rev, 1,
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|
|
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|
|
|
|
F.J.Brooks,
and
A.E.Carlsson
(2009).
Nonequilibrium actin polymerization treated by a truncated rate-equation method.
|
| |
Phys Rev E Stat Nonlin Soft Matter Phys, 79,
031914.
|
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|
|
G.Thuijls,
J.J.de Haan,
J.P.Derikx,
I.Daissormont,
M.Hadfoune,
E.Heineman,
and
W.A.Buurman
(2009).
Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock.
|
| |
Shock, 31,
164-169.
|
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|
|
|
|
|
H.G.Mannherz,
and
E.Hannappel
(2009).
The beta-thymosins: intracellular and extracellular activities of a versatile actin binding protein family.
|
| |
Cell Motil Cytoskeleton, 66,
839-851.
|
|
|
|
|
|
|
H.Y.Kueh,
and
T.J.Mitchison
(2009).
Structural plasticity in actin and tubulin polymer dynamics.
|
| |
Science, 325,
960-963.
|
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|
|
|
I.A.Belyantseva,
B.J.Perrin,
K.J.Sonnemann,
M.Zhu,
R.Stepanyan,
J.McGee,
G.I.Frolenkov,
E.J.Walsh,
K.H.Friderici,
T.B.Friedman,
and
J.M.Ervasti
(2009).
Gamma-actin is required for cytoskeletal maintenance but not development.
|
| |
Proc Natl Acad Sci U S A, 106,
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I.T.Whiteman,
O.L.Gervasio,
K.M.Cullen,
G.J.Guillemin,
E.V.Jeong,
P.K.Witting,
S.T.Antao,
L.S.Minamide,
J.R.Bamburg,
and
C.Goldsbury
(2009).
Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.
|
| |
J Neurosci, 29,
12994-13005.
|
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|
|
|
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|
J.A.Ditlev,
N.M.Vacanti,
I.L.Novak,
and
L.M.Loew
(2009).
An open model of actin dendritic nucleation.
|
| |
Biophys J, 96,
3529-3542.
|
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|
|
|
|
|
J.R.Bamburg,
and
G.S.Bloom
(2009).
Cytoskeletal pathologies of Alzheimer disease.
|
| |
Cell Motil Cytoskeleton, 66,
635-649.
|
|
|
|
|
|
|
J.van Rheenen,
J.Condeelis,
and
M.Glogauer
(2009).
A common cofilin activity cycle in invasive tumor cells and inflammatory cells.
|
| |
J Cell Sci, 122,
305-311.
|
|
|
|
|
|
|
K.E.Bryan,
and
P.A.Rubenstein
(2009).
Allele-specific Effects of Human Deafness {gamma}-Actin Mutations (DFNA20/26) on the Actin/Cofilin Interaction.
|
| |
J Biol Chem, 284,
18260-18269.
|
|
|
|
|
|
|
M.Gandhi,
V.Achard,
L.Blanchoin,
and
B.L.Goode
(2009).
Coronin switches roles in actin disassembly depending on the nucleotide state of actin.
|
| |
Mol Cell, 34,
364-374.
|
|
|
|
|
|
|
M.Morín,
K.E.Bryan,
F.Mayo-Merino,
R.Goodyear,
A.Mencía,
S.Modamio-Høybjør,
I.del Castillo,
J.M.Cabalka,
G.Richardson,
F.Moreno,
P.A.Rubenstein,
and
M.A.Moreno-Pelayo
(2009).
In vivo and in vitro effects of two novel gamma-actin (ACTG1) mutations that cause DFNA20/26 hearing impairment.
|
| |
Hum Mol Genet, 18,
3075-3089.
|
|
|
|
|
|
|
M.Oser,
and
J.Condeelis
(2009).
The cofilin activity cycle in lamellipodia and invadopodia.
|
| |
J Cell Biochem, 108,
1252-1262.
|
|
|
|
|
|
|
M.Takaine,
O.Numata,
and
K.Nakano
(2009).
Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring.
|
| |
EMBO J, 28,
3117-3131.
|
|
|
|
|
|
|
R.Kardos,
K.Pozsonyi,
E.Nevalainen,
P.Lappalainen,
M.Nyitrai,
and
G.Hild
(2009).
The effects of ADF/cofilin and profilin on the conformation of the ATP-binding cleft of monomeric actin.
|
| |
Biophys J, 96,
2335-2343.
|
|
|
|
|
|
|
S.Leyman,
M.Sidani,
L.Ritsma,
D.Waterschoot,
R.Eddy,
D.Dewitte,
O.Debeir,
C.Decaestecker,
J.Vandekerckhove,
J.van Rheenen,
C.Ampe,
J.Condeelis,
and
M.Van Troys
(2009).
Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering.
|
| |
Mol Biol Cell, 20,
4509-4523.
|
|
|
|
|
|
|
T.K.Beuria,
S.Mullapudi,
E.Mileykovskaya,
M.Sadasivam,
W.Dowhan,
and
W.Margolin
(2009).
Adenine Nucleotide-dependent Regulation of Assembly of Bacterial Tubulin-like FtsZ by a Hypermorph of Bacterial Actin-like FtsA.
|
| |
J Biol Chem, 284,
14079-14086.
|
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|
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|
T.Shemesh,
A.B.Verkhovsky,
T.M.Svitkina,
A.D.Bershadsky,
and
M.M.Kozlov
(2009).
Role of focal adhesions and mechanical stresses in the formation and progression of the lamellipodium-lamellum interface [corrected].
|
| |
Biophys J, 97,
1254-1264.
|
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|
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|
T.Tsuji,
T.Miyoshi,
C.Higashida,
S.Narumiya,
and
N.Watanabe
(2009).
An order of magnitude faster AIP1-associated actin disruption than nucleation by the Arp2/3 complex in lamellipodia.
|
| |
PLoS ONE, 4,
e4921.
|
|
|
|
|
|
|
W.H.Lin,
and
D.J.Webb
(2009).
Actin and Actin-Binding Proteins: Masters of Dendritic Spine Formation, Morphology, and Function.
|
| |
Open Neurosci J, 3,
54-66.
|
|
|
|
|
|
|
Y.Shi,
C.G.Pontrello,
K.A.DeFea,
L.F.Reichardt,
and
I.M.Ethell
(2009).
Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity.
|
| |
J Neurosci, 29,
8129-8142.
|
|
|
|
|
|
|
B.R.McCullough,
L.Blanchoin,
J.L.Martiel,
and
E.M.De la Cruz
(2008).
Cofilin increases the bending flexibility of actin filaments: implications for severing and cell mechanics.
|
| |
J Mol Biol, 381,
550-558.
|
|
|
|
|
|
|
C.W.Pak,
K.C.Flynn,
and
J.R.Bamburg
(2008).
Actin-binding proteins take the reins in growth cones.
|
| |
Nat Rev Neurosci, 9,
136-147.
|
|
|
|
|
|
|
E.E.Grintsevich,
S.A.Benchaar,
D.Warshaviak,
P.Boontheung,
F.Halgand,
J.P.Whitelegge,
K.F.Faull,
R.R.Loo,
D.Sept,
J.A.Loo,
and
E.Reisler
(2008).
Mapping the cofilin binding site on yeast G-actin by chemical cross-linking.
|
| |
J Mol Biol, 377,
395-409.
|
|
|
|
|
|
|
F.Huber,
J.Käs,
and
B.Stuhrmann
(2008).
Growing actin networks form lamellipodium and lamellum by self-assembly.
|
| |
Biophys J, 95,
5508-5523.
|
|
|
|
|
|
|
F.P.Lai,
M.Szczodrak,
J.Block,
J.Faix,
D.Breitsprecher,
H.G.Mannherz,
T.E.Stradal,
G.A.Dunn,
J.V.Small,
and
K.Rottner
(2008).
Arp2/3 complex interactions and actin network turnover in lamellipodia.
|
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PDB code:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
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only a partial list as not all journals are covered by
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so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
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